Evidence map›Paper›PMID 37208193›Full record

ArticleLife science alliance2023

Expression of TMPRSS2 is up-regulated by bacterial flagellin, LPS, and Pam3Cys in human airway cells.

Marie Schwerdtner, Annika Skalik, Hannah Limburg, Jeff Bierwagen, Anna Lena Jung, Jens Dorna, Andreas Kaufmann, Stefan Bauer, Bernd Schmeck, Eva Böttcher-Friebertshäuser

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Life science alliance, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Anti-inflammatory effects ofFrontiers in pharmacology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 3 countries.

Marie SchwerdtnerInstitute of Virology, Philipps-University Marburg, Marburg, Germany.
Annika SkalikInstitute of Virology, Philipps-University Marburg, Marburg, Germany.
Hannah LimburgInstitute of Virology, Philipps-University Marburg, Marburg, Germany.
Jeff BierwagenInstitute for Lung Research, Universities of Giessen and Marburg Lung Center, Philipps-University Marburg, German Center for Lung Research (DZL), Marburg, Germany.ORCID https://orcid.org/0000-0002-3427-3504
Anna Lena JungInstitute for Lung Research, Universities of Giessen and Marburg Lung Center, Philipps-University Marburg, German Center for Lung Research (DZL), Marburg, Germany.
Jens DornaInstitute of Immunology, Philipps-University Marburg, Marburg, Germany.
Andreas KaufmannInstitute of Immunology, Philipps-University Marburg, Marburg, Germany.
Stefan BauerInstitute of Immunology, Philipps-University Marburg, Marburg, Germany.ORCID https://orcid.org/0000-0002-8462-1845
Bernd SchmeckInstitute for Lung Research, Universities of Giessen and Marburg Lung Center, Philipps-University Marburg, German Center for Lung Research (DZL), Marburg, Germany.
Eva Böttcher-FriebertshäuserInstitute of Virology, Philipps-University Marburg, Marburg, Germany friebertshaeuser@staff.uni-marburg.de.ORCID https://orcid.org/0000-0002-0007-8110
Institute of Virology of the Slovak Academy of Sciences · SKInstitute of Immunology · HRGerman Center for Lung Research · DEPhilipps University of Marburg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Many viruses require proteolytic activation of their envelope proteins for infectivity, and relevant host proteases provide promising drug targets. The transmembrane serine protease 2 (TMPRSS2) has been identified as a major activating protease of influenza A virus (IAV) and various coronaviruses (CoV). Increased TMPRSS2 expression has been associated with a higher risk of severe influenza infection and enhanced susceptibility to SARS-CoV-2. Here, we found that

Indexed as

Serine EndopeptidasesFlagellinHumansInfluenza A virusInfluenza A Virus, H3N2 SubtypeLipopolysaccharidesLipoproteinsRNA, MessengerSARS-CoV-2FlagellinLipopolysaccharidesLipoproteinsN-palmitoyl-S-(2,3-bis(palmitoyloxy)propyl)cysteinyl-seryl-lysyl-lysyl-lysyl-lysineRNA, MessengerSerine EndopeptidasesTMPRSS2 protein, human

Identifiers

PMID37208193
PMCPMC10200810
OpenAlexW4377142756

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.