ArticleThe American journal of clinical nutrition2022
Is dietary choline intake related to dementia and Alzheimer's disease risks? Results from the Framingham Heart Study.
Article in The American journal of clinical nutrition, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 2 of them syntheses that pooled it.
What it found
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The trial behind it
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Who cites it
40 citing papers in PubMed, 2 syntheses or guidelines pooled it, 55 citations in OpenAlex.
- Dietary choline intake and incident dementia in middle-aged and older adults: a prospective cohort study and dose-response meta-analysis.Nutrition journal · 2026Pooled it
- Effect of nutrition in Alzheimer's disease: A systematic review.Frontiers in neuroscience · 2023Pooled it
- Gut Microbial Choline TMA-Lyase CutC: From Metabolic Mechanism to a Novel Therapeutic Target for Diseases.Nutrients · 2026Review
- Dietary Choline and Betaine Intake and 2-year Changes in Cognitive Function in Older Adults With Overweight or Obesity and Metabolic Syndrome: A Prospective Cohort Analysis.The American journal of clinical nutrition · 2026Article
- Drug Discovery Targeting Nicotinic Acetylcholine Receptors for Hearing Loss.International journal of molecular sciences · 2026Review
- Can Nutrition Modulate the Progression of Alzheimer's Disease? A Narrative Review.Current nutrition reports · 2026Review
- Relationship Between Dietary Choline Intake and Cognitive Function in the United States: A Cross-Sectional Study of the 2011-2014 NHANES Cycle.Food science & nutrition · 2026Article
- Food sources of choline and their contribution to choline adequacy in U.S. older adults.Journal of food composition and analysis : an official publication of the United Nations University, International Network of Food Data Systems · 2025Article
- Plasma-based brain age as a potential biomarker for cognitive health and risk of brain-related disorders.Communications medicine · 2025Article
- Review
- Brain DNA Methylation Atlas of AppAging cell · 2025Article
- Perinatal Choline Supplementation Promotes Resilience Against Progression of Alzheimer's Disease-Like Brain Transcriptomic Signatures in AppAging cell · 2025Article
- Metabolic dysfunction-associated steatotic liver disease alters brain function and behavior: Insights from liver-targeted siRNA therapy.Science advances · 2025Article
- Higher vitamin BAlzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- The association of dietary choline intakes with cognitive function among the older people in underdeveloped regions: findings from the NCDFaC study.Nutrition journal · 2025Article
- Nutritional Aspects of Eggs for a Healthy and Sustainable Consumption: A Narrative Review.Food science & nutrition · 2025Review
- Vildagliptin modulates the microbiota and induces an immunometabolic profile compatible with neuroprotection in type 2 diabetes.Scientific reports · 2025Article
- Dietary Choline Intake and Risk of Alzheimer's Dementia in Older Adults.The Journal of nutrition · 2025Article
- Gut microbiota-mediated choline metabolism exacerbates cognitive impairment induced by chronic cerebral hypoperfusion.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2025Article
- Association of Dietary Choline Intake With Incidence of Frailty: A Nationwide Prospective Cohort Study From China.Journal of cachexia, sarcopenia and muscle · 2025Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundThe positive association of choline for cognition has been reported in both animal and human studies, yet the associations of choline with the risks of incident dementia or Alzheimer's disease (AD) in humans is unclear.
objectivesOur objective was to test the hypothesis that lower or higher dietary choline intake is associated with increased or decreased, respectively, risks of incident dementia and AD.
methodsData from the Framingham Heart Study Offspring Cohort exam 5 to exam 9 were used. Participants were free of dementia and stroke, with a valid self-reported 126-item Harvard FFQ at exam 5. The intakes of total choline, its contributing compounds, and betaine were estimated based on a published nutrient database. The intakes were updated at each exam to represent the cumulative average intake across the 5 exams. The associations between dietary choline intakes and incident dementia and AD were examined in mixed-effect Cox proportional hazard models, adjusting for covariates.
resultsA total of 3224 participants (53.8% female; mean ± SD age, 54.5 ± 9.7 y) were followed up for a mean ± SD of 16.1 ± 5.1 y (1991-2011). There were 247 incident dementia cases, of which 177 were AD. Dietary choline intake showed nonlinear relationships with incident dementia and AD. After adjusting for covariates, low choline intake (defined as ≤ 219 and ≤ 215 mg/d for dementia and AD, respectively) was significantly associated with incident dementia and incident AD.
conclusionsLow choline intake was associated with increased risks of incident dementia and AD.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.