ArticleJournal of the American Academy of Child and Adolescent Psychiatry2023
Perinatal Factors and Emotional, Cognitive, and Behavioral Dysregulation in Childhood and Adolescence.
Article in Journal of the American Academy of Child and Adolescent Psychiatry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.
- Early Predictors of the Childhood Dysregulation Profile: A Systematic Review.Clinical child and family psychology review · 2026Pooled it
- Predicting 7-year-olds mental health in the perinatal period: Development and internal validation of a multivariable model using the prospective ALSPAC cohort.JCPP advances · 2026Article
- Association of maternal smoking during pregnancy with youth depression and subsequent adult chronic diseases in offspring.Translational psychiatry · 2026Article
- Network relationships between emotional dysregulation and ADHD symptoms: an investigation of 13,207 clinical children and adolescents.European child & adolescent psychiatry · 2026Article
- Perinatal insult dimensions and developmental trajectories of psychotic-like experiences.Schizophrenia (Heidelberg, Germany) · 2025Article
- Unraveling Childhood Obesity: A Grounded Theory Approach to Psychological, Social, Parental, and Biological Factors.Children (Basel, Switzerland) · 2024Review
- The impact of excessive maternal weight on the risk of neuropsychiatric disorders in offspring-a narrative review of clinical studies.Pharmacological reports : PR · 2024Review
Corrections and comments
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Authors and funding
24 authors at 12 institutions in 1 country.
Funding
Abstract
objectiveThis cohort study assessed perinatal factors known to be related to maternal and neonatal inflammation and hypothesized that several would be associated with emotional, cognitive, and behavioral dysregulation in youth.
methodThe Environmental influences on Child Health Outcomes (ECHO) is a research consortium of 69 pediatric longitudinal cohorts. A subset of 18 cohorts that had both Child Behavior Checklist (CBCL) data on children (6-18 years) and information on perinatal exposures including maternal prenatal infections was used. Children were classified as having the CBCL-Dysregulation Profile (CBCL-DP) if the sum of their T scores for 3 CBCL subscales (attention, anxious/depressed, and aggression) was ≥180. Primary exposures were perinatal factors associated with maternal and/or neonatal inflammation, and associations between these and outcome were assessed.
resultsApproximately 13.4% of 4,595 youth met criteria for CBCL-DP. Boys were affected more than girls (15.1% vs 11.5%). More youth with CBCL-DP (35%) were born to mothers with prenatal infections compared with 28% of youth without CBCL-DP. Adjusted odds ratios indicated the following were significantly associated with dysregulation: having a first-degree relative with a psychiatric disorder; being born to a mother with lower educational attainment, who was obese, had any prenatal infection, and/or who smoked tobacco during pregnancy.
conclusionIn this large study, a few modifiable maternal risk factors with established roles in inflammation (maternal lower education, obesity, prenatal infections, and smoking) were strongly associated with CBCL-DP and could be targets for interventions to improve behavioral outcomes of offspring. DIVERSITY & INCLUSION STATEMENT: We worked to ensure race, ethnic, and/or other types of diversity in the recruitment of human participants. One or more of the authors of this paper self-identifies as a member of one or more historically underrepresented sexual and/or gender groups in science. We actively worked to promote sex and gender balance in our author group. The author list of this paper includes contributors from the location and/or community where the research was conducted who participated in the data collection, design, analysis, and/or interpretation of the work.
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Registered trials
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