Evidence map›Paper›PMID 37206878›Full record

ArticleMaterials today. Bio2023

Magnetic microspheres mimicking certain functions of macrophages: Towards precise antibacterial potency for bone defect healing.

Qiao Zhou, Jun Liu, Jia Yan, Zhaobin Guo, Feimin Zhang

Open access · goldAbstract read
In one paragraph

Article in Materials today. Bio, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.8field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
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  10. Artificial Neutrophils Against Vascular Graft Infection.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Qiao ZhouJiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, 210029, China.
Jun LiuJiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, 210029, China.
Jia YanJiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, 210029, China.
Zhaobin GuoInstitute for Nanobiotechnology, Johns Hopkins University, Baltimore, MD, 21218, USA.
Feimin ZhangJiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, 210029, China.
Nanjing Medical University · CNJohns Hopkins University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A variety of novel biomaterials have recently been developed to promote bone regeneration. However, the current biomaterials cannot accurately and effectively resist bacterial invasion. In this study, we constructed microspheres that mimic certain functions of macrophages as additives to bone repair materials, which can be manipulated as demanded to resist bacteria effectively and protect bone defect healing. Firstly, we prepared gelatin microspheres (GMSs) by an emulsion-crosslinking method, which were subsequently coated with polydopamine (PDA). Then, amino antibacterial nanoparticles obtained by a nanoprecipitation-self-assembly method and commercial amino magnetic nanoparticles were modified onto these PDA-coated GMSs to construct the functionalized microspheres (FMSs). The results showed that the FMSs possessed a rough topography and could be manipulated by a 100-400 ​mT static magnetic field to migrate directionally in unsolidified hydrogels. Moreover,

Indexed as

AntibacterialLight-magnetism-responsive materialMacrophageMicrosphereReactive oxygen species

Identifiers

PMID37206878
PMCPMC10189291
OpenAlexW4367624581

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.