Evidence map›Paper›PMID 37206458›Full record

ArticleJPGN reports2021

Gastric Adenocarcinoma and Proximal Polyposis of the Stomach in a Hispanic Pediatric Patient With APC Gene Variant c.-191T>G.

Annette Gawron Roberts, Malgorzata Bujarska, Mislen Bauer, Carole Brathwaite, Liset Pelaez, Jesse Reeves-Garcia

Open access · hybridAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in JPGN reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Annette Gawron RobertsFrom the Departments of Gastroenterology, Medical Education, and Pathology, Nicklaus Children's Hospital, Miami, Florida.
Malgorzata BujarskaFrom the Departments of Gastroenterology, Medical Education, and Pathology, Nicklaus Children's Hospital, Miami, Florida.
Mislen BauerFrom the Departments of Gastroenterology, Medical Education, and Pathology, Nicklaus Children's Hospital, Miami, Florida.
Carole BrathwaiteFrom the Departments of Gastroenterology, Medical Education, and Pathology, Nicklaus Children's Hospital, Miami, Florida.
Liset PelaezFrom the Departments of Gastroenterology, Medical Education, and Pathology, Nicklaus Children's Hospital, Miami, Florida.
Jesse Reeves-GarciaFrom the Departments of Gastroenterology, Medical Education, and Pathology, Nicklaus Children's Hospital, Miami, Florida.
Miami Children's Hospital · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gastric adenocarcinoma and proximal polyposis of the stomach (GAPPS) is a rare gastric polyposis syndrome defined by numerous polyps (>100) in the fundus and body of the stomach with sparing of the lesser curvature and antrum. GAPPS is linked to a variant in the promoter 1B region of the APC gene. These variants carry a high risk of developing gastric adenocarcinoma, which can occur at an early age. We report a case of GAPPS discovered in a 16-year-old Hispanic girl after endoscopy detected extensive fundic gland polyposis. Genetic testing revealed a promoter 1B point mutation of the APC gene, variant c.-191T>G. Although similar variants have been reported (i.e., c.-191T>C, c.-195A>C, c.-192A>G) in association with GAPPS, variant c.-191T>G has not nor has GAPPS ever been described in a Hispanic individual before.

Indexed as

APCAPC gene variantsGAPPSgastric adenocarcinomagastric cancergastric polyposisgastric polypshereditary cancer syndromepolyposispolyposis syndromesPromoter 1B

Identifiers

PMID37206458
PMCPMC10191560
OpenAlexW3204564970

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.