Evidence map›Paper›PMID 37206405›Full record

ArticleChemical science2023

Cascade autohydrolysis of Alzheimer's Aβ peptides.

Martin Wolfram, Manish K Tiwari, Tue Hassenkam, Ming Li, Morten J Bjerrum, Morten Meldal

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemical science, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Photolytic disruption of Alzheimer's amyloid AβCommunications chemistry · 2026
    Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Martin WolframDepartment of Chemistry, University of Copenhagen Universitetsparken 5 2100 Copenhagen Denmark martin.wolfram@nano.ku.dk meldal@chem.ku.dk +45 27202355 +45 21308299.ORCID https://orcid.org/0000-0003-2464-855X
Manish K TiwariDepartment of Chemistry, University of Copenhagen Universitetsparken 5 2100 Copenhagen Denmark martin.wolfram@nano.ku.dk meldal@chem.ku.dk +45 27202355 +45 21308299.
Tue HassenkamGlobe Institute, Section for Geobiology, Copenhagen University Øster Voldgade 5-7 1350 Copenhagen K Denmark.
Ming LiTechnical University of Denmark, The Danish Hydrocarbon Research and Technology Centre Elektrovej, 2800 Kongens Lyngby Denmark.
Morten J BjerrumDepartment of Chemistry, University of Copenhagen Universitetsparken 5 2100 Copenhagen Denmark martin.wolfram@nano.ku.dk meldal@chem.ku.dk +45 27202355 +45 21308299.ORCID https://orcid.org/0000-0002-8410-627X
Morten MeldalDepartment of Chemistry, University of Copenhagen Universitetsparken 5 2100 Copenhagen Denmark martin.wolfram@nano.ku.dk meldal@chem.ku.dk +45 27202355 +45 21308299.
University of Copenhagen · DKTechnical University of Denmark · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Protein/peptide self-assembly into amyloid structures associates with major neurodegenerative disorders such as Alzheimer's disease (AD). Soluble assemblies (oligomers) of the Aβ peptide and their aggregates are perceived as neurotoxic species in AD. While screening for synthetic cleavage agents that could break down such aberrant assemblies through hydrolysis, we observed that the assemblies of Aβ oligopeptides, containing the nucleation sequence Aβ

Identifiers

PMID37206405
PMCPMC10189894
OpenAlexW4365396766

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.