Evidence map›Paper›PMID 37206391›Full record

ArticleChemical science2023

Expedient synthesis and luminescence sensing of the inositol pyrophosphate cellular messenger 5-PP-InsP

Megan L Shipton, Fathima A Jamion, Simon Wheeler, Andrew M Riley, Felix Plasser, Barry V L Potter, Stephen J Butler

Open access · diamondAbstract read
In one paragraph

Article in Chemical science, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.0field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. The Diphosphoinositol Polyphosphate Phosphohydrolase 1 family binds IPInternational journal of biological macromolecules · 2026
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  2. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Megan L ShiptonMedicinal Chemistry & Drug Discovery, Department of Pharmacology, University of Oxford Mansfield Road Oxford OX1 3QT UK barry.potter@pharm.ox.ac.uk.ORCID https://orcid.org/0000-0002-9982-0927
Fathima A JamionDepartment of Chemistry, Loughborough University Epinal Way, Loughborough LE11 3TU UK S.J.Butler@lboro.ac.uk.
Simon WheelerDepartment of Chemistry, Loughborough University Epinal Way, Loughborough LE11 3TU UK S.J.Butler@lboro.ac.uk.ORCID https://orcid.org/0000-0003-0215-8648
Andrew M RileyMedicinal Chemistry & Drug Discovery, Department of Pharmacology, University of Oxford Mansfield Road Oxford OX1 3QT UK barry.potter@pharm.ox.ac.uk.ORCID https://orcid.org/0000-0001-9003-3540
Felix PlasserDepartment of Chemistry, Loughborough University Epinal Way, Loughborough LE11 3TU UK S.J.Butler@lboro.ac.uk.ORCID https://orcid.org/0000-0003-0751-148X
Barry V L PotterMedicinal Chemistry & Drug Discovery, Department of Pharmacology, University of Oxford Mansfield Road Oxford OX1 3QT UK barry.potter@pharm.ox.ac.uk.ORCID https://orcid.org/0000-0003-3255-9135
Stephen J ButlerDepartment of Chemistry, Loughborough University Epinal Way, Loughborough LE11 3TU UK S.J.Butler@lboro.ac.uk.ORCID https://orcid.org/0000-0001-8109-3330
Loughborough University · GBUniversity of Oxford · GB

Funding

Wellcome Trust 101010
6 · The paper itself

Abstract

Inositol pyrophosphates are important biomolecules associated with apoptosis, cell growth and kinase regulation, yet their exact biological roles are still emerging and probes do not exist for their selective detection. We report the first molecular probe for the selective and sensitive detection of the most abundant cellular inositol pyrophosphate 5-PP-InsP

Identifiers

PMID37206391
PMCPMC10189900
OpenAlexW4365799013

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.