Evidence map›Paper›PMID 37206240›Full record

ReviewBioengineering & translational medicine2023

Application of nano-radiosensitizers in combination cancer therapy.

Mohammad Varzandeh, Leila Sabouri, Vahid Mansouri, Maliheh Gharibshahian, Nima Beheshtizadeh, Michael R Hamblin, Nima Rezaei

Open access · goldAbstract readReview
In one paragraph

Review in Bioengineering & translational medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
9.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 35 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Biodegradable hafnium-doped CaCONanomedicine (London, England) · 2024
    Article
  9. Review
  10. Article
  11. Application of nano-radiosensitizers in combination cancer therapy.Bioengineering & translational medicine · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Mohammad VarzandehDepartment of Materials Engineering Isfahan University of Technology Isfahan Iran.
Leila SabouriAmitisGen TECH Dev Group Tehran Iran.
Vahid MansouriRegenerative Medicine Group (REMED) Universal Scientific Education and Research Network (USERN) Tehran Iran.
Maliheh GharibshahianRegenerative Medicine Group (REMED) Universal Scientific Education and Research Network (USERN) Tehran Iran.
Nima BeheshtizadehRegenerative Medicine Group (REMED) Universal Scientific Education and Research Network (USERN) Tehran Iran.ORCID https://orcid.org/0000-0002-2621-570X
Michael R HamblinLaser Research Center, Faculty of Health Science University of Johannesburg Doornfontein South Africa.
Nima RezaeiNetwork of Immunity in Infection, Malignancy and Autoimmunity (NIIMA) Universal Scientific Education and Research Network (USERN) Tehran Iran.ORCID https://orcid.org/0000-0002-3836-1827
Universal Scientific Education and Research Network · IRAmirkabir University of Technology · IRIsfahan University of Technology · IRUniversity of Johannesburg · ZA

Funding

Photodynamic Therapy of Localized InfectionsR01AI050875 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI HAMBLIN, MICHAEL R · 2003 to 2017
$4.8M
Synergistic Photodynamic Therapy for Catherer-Associated Urinary Tract InfectionsR21AI121700 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI HAMBLIN, MICHAEL R · 2016 to 2017
$462k
NIAID NIH HHS R01 AI050875NIAID NIH HHS R21 AI121700
6 · The paper itself

Abstract

Radiosensitizers are compounds or nanostructures, which can improve the efficiency of ionizing radiation to kill cells. Radiosensitization increases the susceptibility of cancer cells to radiation-induced killing, while simultaneously reducing the potentially damaging effect on the cellular structure and function of the surrounding healthy tissues. Therefore, radiosensitizers are therapeutic agents used to boost the effectiveness of radiation treatment. The complexity and heterogeneity of cancer, and the multifactorial nature of its pathophysiology has led to many approaches to treatment. The effectiveness of each approach has been proven to some extent, but no definitive treatment to eradicate cancer has been discovered. The current review discusses a broad range of nano-radiosensitizers, summarizing possible combinations of radiosensitizing NPs with several other types of cancer therapy options, focusing on the benefits and drawbacks, challenges, and future prospects.

Indexed as

cancer treatmentcombination therapyhigh‐z nanoparticlesoxygen‐mimeticsradiosensitizers

Identifiers

PMID37206240
PMCPMC10189501
OpenAlexW4319970146

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.