Evidence map›Paper›PMID 37206223›Full record

ArticleBioengineering & translational medicine2023

Galactosylated hydroxyl-polyamidoamine dendrimer targets hepatocytes and improves therapeutic outcomes in a severe model of acetaminophen poisoning-induced liver failure.

Joshua E Porterfield, Rishi Sharma, Ambar Scarlet Jimenez, Nirnath Sah, Sean McCracken, Lucia Zhang, Hyoung-Tae An, Seulki Lee, Sujatha Kannan, Anjali Sharma and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioengineering & translational medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
3.2field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
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  8. Nano Approaches to Nucleic Acid Delivery: Barriers, Solutions, and Current Landscape.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Joshua E PorterfieldCenter for Nanomedicine, Department of Ophthalmology Wilmer Eye Institute, Johns Hopkins University School of Medicine Baltimore Maryland USA.
Rishi SharmaCenter for Nanomedicine, Department of Ophthalmology Wilmer Eye Institute, Johns Hopkins University School of Medicine Baltimore Maryland USA.
Ambar Scarlet JimenezCenter for Nanomedicine, Department of Ophthalmology Wilmer Eye Institute, Johns Hopkins University School of Medicine Baltimore Maryland USA.
Nirnath SahDepartment of Biomedical Engineering Johns Hopkins University Baltimore Maryland USA.
Sean McCrackenCenter for Nanomedicine, Department of Ophthalmology Wilmer Eye Institute, Johns Hopkins University School of Medicine Baltimore Maryland USA.
Lucia ZhangCenter for Nanomedicine, Department of Ophthalmology Wilmer Eye Institute, Johns Hopkins University School of Medicine Baltimore Maryland USA.
Hyoung-Tae AnCenter for Nanomedicine, Department of Ophthalmology Wilmer Eye Institute, Johns Hopkins University School of Medicine Baltimore Maryland USA.
Seulki LeeCenter for Nanomedicine, Department of Ophthalmology Wilmer Eye Institute, Johns Hopkins University School of Medicine Baltimore Maryland USA.
Sujatha KannanCenter for Nanomedicine, Department of Ophthalmology Wilmer Eye Institute, Johns Hopkins University School of Medicine Baltimore Maryland USA.
Anjali SharmaCenter for Nanomedicine, Department of Ophthalmology Wilmer Eye Institute, Johns Hopkins University School of Medicine Baltimore Maryland USA.
Rangaramanujam M KannanCenter for Nanomedicine, Department of Ophthalmology Wilmer Eye Institute, Johns Hopkins University School of Medicine Baltimore Maryland USA.ORCID https://orcid.org/0000-0002-3712-7836
Johns Hopkins University · USKennedy Krieger Institute · US

Funding

Wilmer Core Grant for Vision ResearchP30EY001765 · NEI · JOHNS HOPKINS UNIVERSITY · PI Ji Yi · 1985 to 2026
$22.1M
HopkinsPREP: Research, Community, Professional Training and Personal GrowthR25GM109441 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI WILSON, KATHERINE L · 2015 to 2024
$3.2M
NEI NIH HHS P30 EY001765NIGMS NIH HHS R25 GM109441
6 · The paper itself

Abstract

Toxicity to hepatocytes caused by various insults including drugs is a common cause of chronic liver failure requiring transplantation. Targeting therapeutics specifically to hepatocytes is often a challenge since they are relatively nonendocytosing unlike the highly phagocytic Kupffer cells in the liver. Approaches that enable targeted intracellular delivery of therapeutics to hepatocytes have significant promise in addressing liver disorders. We synthesized a galactose-conjugated hydroxyl polyamidoamine dendrimer (D4-Gal) that targets hepatocytes efficiently through the asialoglycoprotein receptors in healthy mice and in a mouse model of acetaminophen (APAP)-induced liver failure. D4-Gal localized specifically in hepatocytes and showed significantly better targeting when compared with the non-Gal functionalized hydroxyl dendrimer. The therapeutic potential of D4-Gal conjugated to

Indexed as

acetaminophen poisoningdendrimersdrug deliveryhepatocytes targetingliver injuryN‐acetyl cysteine

Identifiers

PMID37206223
PMCPMC10189448
OpenAlexW4319786103

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.