Evidence map›Paper›PMID 37206216›Full record

ArticleBioengineering & translational medicine2023

Gellan gum spongy-like hydrogel-based dual antibiotic therapy for infected diabetic wounds.

Ana Isabel Mendes, Alexandra Gabriel Fraga, Maria João Peixoto, Ivo Aroso, Adhemar Longatto-Filho, Alexandra Pinto Marques, Jorge Pedrosa

Open access · goldAbstract read
In one paragraph

Article in Bioengineering & translational medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Ana Isabel MendesLife and Health Sciences Research Institute (ICVS) School of Medicine University of Minho Braga Portugal.ORCID https://orcid.org/0000-0003-4724-0784
Alexandra Gabriel FragaLife and Health Sciences Research Institute (ICVS) School of Medicine University of Minho Braga Portugal.ORCID https://orcid.org/0000-0003-2029-1629
Maria João PeixotoLife and Health Sciences Research Institute (ICVS) School of Medicine University of Minho Braga Portugal.ORCID https://orcid.org/0000-0002-4739-3409
Ivo ArosoICVS/3B's-PT Government Associate Laboratory Braga/Guimarães Portugal.ORCID https://orcid.org/0000-0002-0543-548X
Adhemar Longatto-FilhoLife and Health Sciences Research Institute (ICVS) School of Medicine University of Minho Braga Portugal.ORCID https://orcid.org/0000-0002-5779-9752
Alexandra Pinto MarquesICVS/3B's-PT Government Associate Laboratory Braga/Guimarães Portugal.ORCID https://orcid.org/0000-0002-3222-0310
Jorge PedrosaLife and Health Sciences Research Institute (ICVS) School of Medicine University of Minho Braga Portugal.ORCID https://orcid.org/0000-0002-8204-4888
University of Minho · PTHospital de Câncer de Barretos · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diabetic foot infection (DFI) is an important cause of morbidity and mortality. Antibiotics are fundamental for treating DFI, although bacterial biofilm formation and associated pathophysiology can reduce their effectiveness. Additionally, antibiotics are often associated with adverse reactions. Hence, improved antibiotic therapies are required for safer and effective DFI management. On this regard, drug delivery systems (DDSs) constitute a promising strategy. We propose a gellan gum (GG)-based spongy-like hydrogel as a topical and controlled DDS of vancomycin and clindamycin, for an improved dual antibiotic therapy against methicillin-resistant

Indexed as

antibioticsdiabetic ulcershydrogelMRSA infectiontopical delivery

Identifiers

PMID37206216
PMCPMC10189450
OpenAlexW4328124763

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.