Evidence map›Paper›PMID 37206208›Full record

ArticleBioengineering & translational medicine2023

Micelle encapsulation zinc-doped copper oxide nanocomposites reverse Olaparib resistance in ovarian cancer by disrupting homologous recombination repair.

Jingyan Yi, Xin Luo, Jinshan Xing, Aharon Gedanken, Xiukun Lin, Chunxiang Zhang, Gan Qiao

Abstract read
In one paragraph

Article in Bioengineering & translational medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jingyan YiDepartment of Medical Cell Biology and Genetics, School of Basic Medical Sciences, Nucleic Acid Medicine of Luzhou Key Laboratory, Key Laboratory of Medical Electrophysiology, Ministry of Education & Medical Electrophysiological Key Laboratory of Sichuan Province, (Collaborative Innovation Center for Prevention of Cardiovascular Diseases), Institute of Cardiovascular Research Southwest Medical University Luzhou Sichuan 646000 China.
Xin LuoDepartment of Pharmacology, School of Pharmacy, Nucleic Acid Medicine of Luzhou Key Laboratory Southwest Medical University Luzhou Sichuan 646000 China.
Jinshan XingDepartment of Neurosurgery The Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University Luzhou Sichuan 646000 China.
Aharon GedankenCenter for Advanced Materials and Nanotechnology Bar-Ilan University Ramat Gan 52900 Israel.
Xiukun LinCollege of Marine Sciences Beibu Gulf University 12 Binhai Road Qinzhou 535011 Guangxi China.
Chunxiang ZhangNucleic Acid Medicine of Luzhou Key Laboratory, Key Laboratory of Medical Electrophysiology, Ministry of Education & Medical Electrophysiological Key Laboratory of Sichuan Province, (Collaborative Innovation Center for Prevention of Cardiovascular Diseases), Institute of Cardiovascular Research Southwest Medical University Luzhou Sichuan 646000 China.
Gan QiaoDepartment of Pharmacology, School of Pharmacy, Nucleic Acid Medicine of Luzhou Key Laboratory Southwest Medical University Luzhou Sichuan 646000 China.ORCID https://orcid.org/0000-0001-5361-6923

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Micelle Encapsulation Zinc-doped copper oxide nanocomposites (MEnZn-CuO NPs) is a novel doped metal nanomaterial prepared by our group based on Zinc doped copper oxide nanocomposites (Zn-CuO NPs) using non-micellar beam. Compared with Zn-CuO NPs, MEnZn-CuO NPs have uniform nanoproperties and high stability. In this study, we explored the anticancer effects of MEnZn-CuO NPs on human ovarian cancer cells. In addition to affecting cell proliferation, migration, apoptosis and autophagy, MEnZn-CuO NPs have a greater potential for clinical application by inducing HR repair defects in ovarian cancer cells in combination with poly (ADP-ribose) polymerase inhibitors for lethal effects.

Indexed as

antitumor mechanismsHR repairMEnZn‐CuO NPsovarian cancerPARP inhibitors

Identifiers

PMID37206208
PMCPMC10189445

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.