Evidence map›Paper›PMID 37206207›Full record

ArticleBioengineering & translational medicine2023

Non-invasive treatment of ischemia/reperfusion injury: Effective transmission of therapeutic near-infrared light into the human brain through soft skin-conforming silicone waveguides.

Paul T Morse, Samuel Tuck, Mike Kerns, Dennis J Goebel, Junmei Wan, Tom Waddell, Joseph M Wider, Charlotte L Hüttemann, Moh H Malek, Icksoo Lee and 2 more

Open access · goldAbstract read
In one paragraph

Article in Bioengineering & translational medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

Paul T MorseCenter for Molecular Medicine and Genetics Wayne State University School of Medicine Detroit Michigan USA.ORCID https://orcid.org/0000-0003-1530-1466
Samuel TuckCenter for Molecular Medicine and Genetics Wayne State University School of Medicine Detroit Michigan USA.
Mike KernsLumitex, Inc. Strongsville Ohio USA.
Dennis J GoebelDepartment of Ophthalmology, Visual and Anatomical Sciences Wayne State University School of Medicine Detroit Michigan USA.
Junmei WanCenter for Molecular Medicine and Genetics Wayne State University School of Medicine Detroit Michigan USA.
Tom WaddellMitovation, Inc. Innovation Partnerships Startup Incubator University of Michigan North Campus Research Complex Ann Arbor Michigan USA.
Joseph M WiderDepartment of Emergency Medicine University of Michigan Medical School Ann Arbor Michigan USA.
Charlotte L HüttemannCenter for Molecular Medicine and Genetics Wayne State University School of Medicine Detroit Michigan USA.
Moh H MalekDepartment of Health Care Sciences Eugene Applebaum College of Pharmacy & Health Sciences, Wayne State University Detroit Michigan USA.
Icksoo LeeCollege of Medicine Dankook University Cheonan-si Chungcheongnam-do Republic of Korea.
Thomas H SandersonDepartment of Emergency Medicine University of Michigan Medical School Ann Arbor Michigan USA.
Maik HüttemannCenter for Molecular Medicine and Genetics Wayne State University School of Medicine Detroit Michigan USA.ORCID https://orcid.org/0000-0001-6310-7081
Wayne State University · USUniversity of Michigan · USDankook University · KREugene Applebaum College of Pharmacy and Health Sciences · USLuminex (United States) · US

Funding

Development and Testing of LUCID: A Therapeutic Device for Brain Injury Following Infant Cardiac ArrestU44NS125160 · NINDS · MITOVATION, INC. · PI MAIK HUETTEMANN, Thomas Hudson Sanderson · 2022 to 2026
$3.6M
Non-invasive mitochondrial modulation therapy for ischemic strokeR01NS120322 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HUETTEMANN, MAIK, SANDERSON, THOMAS HUDSON · 2021 to 2025
$2.3M
Infant NeuroLUX: A Novel Non-invasive Therapeutic Device for Neonatal Hypoxic Brain InjuryR42NS105238 · NINDS · MITOVATION, INC. · PI HUETTEMANN, MAIK, SANDERSON, THOMAS HUDSON · 2018 to 2020
$1.8M
Control of Cell Respiration and Apoptosis by Phosphorylation of Cytochrome cR01GM116807 · NIGMS · WAYNE STATE UNIVERSITY · PI HUETTEMANN, MAIK · 2017 to 2020
$1.5M
NIGMS NIH HHS R01 GM116807NINDS NIH HHS R01 NS120322NINDS NIH HHS R42 NS105238NINDS NIH HHS U44 NS125160
6 · The paper itself

Abstract

Noninvasive delivery of near-infrared light (IRL) to human tissues has been researched as a treatment for several acute and chronic disease conditions. We recently showed that use of specific IRL wavelengths, which inhibit the mitochondrial enzyme cytochrome

Indexed as

cadaverinfrared lightischemia/reperfusionlight penetrationmitochondriastrokewaveguide

Identifiers

PMID37206207
PMCPMC10189478
OpenAlexW4319438876

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.