Evidence map›Paper›PMID 37206119›Full record

ArticleBiomedical optics express2023

Longitudinal deep network for consistent OCT layer segmentation.

Yufan He, Aaron Carass, Yihao Liu, Peter A Calabresi, Shiv Saidha, Jerry L Prince

Open access · goldAbstract read
In one paragraph

Article in Biomedical optics express, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
5.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 23 citations in OpenAlex.

  1. AI-driven multimodal retinal imaging for early detection and risk stratification of vascular and neurodegenerative diseases.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Yufan HeDept. of Electrical and Computer Engineering, The Johns Hopkins University, Baltimore, MD 21218, USA.
Aaron CarassDept. of Electrical and Computer Engineering, The Johns Hopkins University, Baltimore, MD 21218, USA.
Yihao LiuDept. of Electrical and Computer Engineering, The Johns Hopkins University, Baltimore, MD 21218, USA.
Peter A CalabresiDept. of Neurology, The Johns Hopkins University School of Medicine, MD 21287, USA.
Shiv SaidhaDept. of Neurology, The Johns Hopkins University School of Medicine, MD 21287, USA.
Jerry L PrinceDept. of Electrical and Computer Engineering, The Johns Hopkins University, Baltimore, MD 21218, USA.
Johns Hopkins University · USJohns Hopkins Medicine · US

Funding

Imaging Neurodegeneration in Multiple SclerosisR01NS082347 · NINDS · JOHNS HOPKINS UNIVERSITY · PI PETER A CALABRESI, Shiv Saidha · 2013 to 2026
$7.0M
OCT and OCTA image processing for retinal assessment of people with MSR01EY032284 · NEI · JOHNS HOPKINS UNIVERSITY · PI PRINCE, JERRY L · 2021 to 2024
$1.8M
3D segmentation and registration of macular SD-OCT for application in MSR01EY024655 · NEI · JOHNS HOPKINS UNIVERSITY · PI PRINCE, JERRY L · 2014 to 2017
$1.6M
NEI NIH HHS R01 EY024655NEI NIH HHS R01 EY032284NINDS NIH HHS R01 NS082347
6 · The paper itself

Abstract

Retinal layer thickness is an important bio-marker for people with multiple sclerosis (PwMS). In clinical practice, retinal layer thickness changes in optical coherence tomography (OCT) are widely used for monitoring multiple sclerosis (MS) progression. Recent developments in automated retinal layer segmentation algorithms allow cohort-level retina thinning to be observed in a large study of PwMS. However, variability in these results make it difficult to identify patient-level trends; this prevents patient specific disease monitoring and treatment planning using OCT. Deep learning based retinal layer segmentation algorithms have achieved state-of-the-art accuracy, but the segmentation is performed on each individual scan without utilizing longitudinal information, which can be important in reducing segmentation error and reveal subtle changes in retinal layers. In this paper, we propose a longitudinal OCT segmentation network which achieves more accurate and consistent layer thickness measurements for PwMS.

Identifiers

PMID37206119
PMCPMC10191669
OpenAlexW4360618714

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.