Evidence map›Paper›PMID 37206092›Full record

ArticleJournal of clinical virology plus2023

When rare becomes common: N2 gene-positive, E gene-negative SARS-CoV-2 PCR results between 2021 and 2022.

Frank Bernhard Kraus, Stefan Moritz, Könül Mamadova, Mario Popp, Marija Kocijancic, Beatrice Ludwig-Kraus

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical virology plus, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Frank Bernhard KrausDepartment for Laboratory Medicine, Central Laboratory, University Hospital Halle, Ernst Grube Str. 40, Halle Saale, Sachsen-Anhalt 06120, Germany.
Stefan MoritzSection of Clinical Infectious Diseases, University Hospital Halle, Halle, Sachsen-Anhalt, Germany.
Könül MamadovaDepartment for Laboratory Medicine, Central Laboratory, University Hospital Halle, Ernst Grube Str. 40, Halle Saale, Sachsen-Anhalt 06120, Germany.
Mario PoppSection of Clinical Infectious Diseases, University Hospital Halle, Halle, Sachsen-Anhalt, Germany.
Marija KocijancicDepartment for Laboratory Medicine, Central Laboratory, University Hospital Halle, Ernst Grube Str. 40, Halle Saale, Sachsen-Anhalt 06120, Germany.
Beatrice Ludwig-KrausDepartment for Laboratory Medicine, Central Laboratory, University Hospital Halle, Ernst Grube Str. 40, Halle Saale, Sachsen-Anhalt 06120, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nucleocapsid gene-positive, envelope gene-negative (N2+/E-) SARS-CoV-2 PCR results obtained with the Cepheid Xpert Xpress SARS-CoV-2 assay are an infrequent phenomenon. We assessed the validity of the N2+/E- cases with an indirect approach by analyzing their occurrence in relation to overall positive PCR rates and absolute number of PCR tests (24,909 samples, collected June 2021 to July 2022). Additionally, 3022 samples were analyzed with the Xpert Xpress CoV-2-plus assay in August/September 2022. The incidence of monthly N2+/E- cases closely followed the overall frequency of positive tests (

Indexed as

COVID-19N2 geneRT-PCRSARS-CoV-2Xpert Xpress CoV-2 plusXpert Xpress SARS-CoV-2

Identifiers

PMID37206092
PMCPMC10175079

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.