ArticleWorld journal of gastrointestinal surgery2023
The global epidemiology of upper and lower gastrointestinal bleeding in general population: A systematic review.
Article in World journal of gastrointestinal surgery, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06421389 (Precise Endoscopic Application of Tranexamic Acid and Sucralfate in Gastrointestinal Bleeding), which is not on this map. Cited by 47 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Precise Endoscopic Application of Tranexamic Acid and Sucralfate in Gastrointestinal Bleeding: A Randomized Controlled Trial
Who cites it
47 citing papers in PubMed, 4 syntheses or guidelines pooled it, 62 citations in OpenAlex.
- Risk of gastrointestinal bleeding by specific SSRIs and SNRIs: A systematic review and meta-analysis.British journal of clinical pharmacology · 2026Pooled it
- Role of prokinetic drugs prior to endoscopy in acute upper gastrointestinal bleeding: a systematic review and meta-analysis.Frontiers in gastroenterology (Lausanne, Switzerland) · 2026Pooled it
- Organizational models for acute gastrointestinal bleeding: a systematic review of hospital networks, multidisciplinary care and bloodless programs (2015-2025).Frontiers in medicine · 2026Pooled it
- Tranexamic acid as treatment for acute gastrointestinal bleeding: A comprehensive systematic review and meta-analysis.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2025Pooled it
- High-Dose Oral Omeprazole Versus Continuous Intravenous Pantoprazole in Patients With High-Risk Peptic Ulcer Bleeding: A Single-Blinded Multicenter RCT.Journal of gastroenterology and hepatology · 2026Trial
- A Comparison of the ABC and AIMS65 Scores in Predicting Outcomes in Patients with Acute Upper Gastrointestinal Bleeding: A Retrospective Multicenter Study.Digestive diseases and sciences · 2026Article
- Red cell distribution width-to-albumin ratio predicts mortality in critically ill patients with gastrointestinal bleeding: A retrospective cohort study with external validation.The Journal of international medical research · 2026Article
- An End-to-End Deep Learning System for Gastrointestinal Bleeding Detection and Quantification in Wireless Capsule Endoscopy.Diagnostics (Basel, Switzerland) · 2026Article
- A primer on the imaging approach to acute gastrointestinal bleeding.Abdominal radiology (New York) · 2026Review
- Risk of 30-day all-cause mortality in octogenarians with non-variceal upper gastrointestinal bleeding: a multinational analysis.European geriatric medicine · 2026Article
- Pharmacological Management of Peptic Ulcer Bleeding.The Korean journal of helicobacter and upper gastrointestinal research · 2026Review
- Diabetes Duration, Severity, and the Risk of Gastrointestinal Bleeding: What the Gut Tells Us about Glucose.Gut and liver · 2026Article
- Prognostic Value of the Neutrophil Percentage-to-Albumin Ratio in Acute Non-Variceal Upper Gastrointestinal Bleeding.Journal of clinical medicine · 2026Article
- Development and internal validation of a machine learning-based model to predict 1-year all-cause mortality in patients with gastrointestinal bleeding with type 2 diabetes.BMC medical informatics and decision making · 2026Article
- Systemic Inflammation Response Index (SIRI) and Aggregate Index of Systemic Inflammation (AISI) as Predictors of Mortality in Patients with Upper Gastrointestinal Bleeding.Journal of clinical medicine · 2026Article
- Article
- Coil Embolization of an Appendiceal Artery Bleed Leading to Appendicitis and Surgical Resection.European journal of case reports in internal medicine · 2026Article
- Article
- CHANGING PATTERNS IN THE EPIDEMIOLOGY OF ACUTEGASTROINTESTINAL BLEEDING IN BRAZIL OVER THE LAST 12 YEARS.Arquivos de gastroenterologia · 2026Article
- Association between a 24-h increase in blood urea nitrogen and clinical outcomes in acute non-variceal upper gastrointestinal bleeding: a dual-center retrospective cohort study.Therapeutic advances in gastroenterology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGastrointestinal bleeding (GIB) is a common and potentially life-threatening clinical event. To date, the literature on the long-term global epidemiology of GIB has not been systematically reviewed.
aimTo systematically review the published literature on the worldwide epidemiology of upper and lower GIB.
methodsEMBASE
resultsOf 4203 retrieved database hits, 41 studies were included, comprising a total of around 4.1 million patients with GIB worldwide from 1980-2012. Thirty-three studies reported rates for UGIB, four for LGIB, and four presented data on both. Incidence rates ranged from 15.0 to 172.0/100000 person-years for UGIB, and from 20.5 to 87.0/100000 person-years for LGIB. Thirteen studies reported on temporal trends, generally showing an overall decline in UGIB incidence over time, although a slight increase between 2003 and 2005 followed by a decline was shown in 5/13 studies. GIB-related mortality data were available from six studies for UGIB, with rates ranging from 0.9 to 9.8/100000 person-years, and from three studies for LGIB, with rates ranging from 0.8 to 3.5/100000 person-years. Case-fatality rate ranged from 0.7% to 4.8% for UGIB and 0.5% to 8.0% for LGIB. Rates of rebleeding ranged from 7.3% to 32.5% for UGIB and from 6.7% to 13.5% for LGIB. Two main areas of potential bias were the differences in the operational GIB definition used and inadequate information on how missing data were handled.
conclusionWide variation was seen in estimates of GIB epidemiology, likely due to high heterogeneity between studies however, UGIB showed a decreasing trend over the years. Epidemiological data were more widely available for UGIB than for LGIB.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.