ArticleFrontiers in psychiatry2023
Case report: Preemptive intervention for an infant with early signs of autism spectrum disorder during the first year of life.
Article in Frontiers in psychiatry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06512649 (Early Recognition and Intervention in Siblings at High-risk for Neurodevelopmental Disorder), which is not on this map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Early Recognition and Intervention in Siblings at High-risk for Neurodevelopmental Disorder
Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Parent-Mediated Interventions for ASD Under 3 Years: A Systematic Review, Meta Analysis, and Moderator Analyses.Journal of autism and developmental disorders · 2026Pooled it
- Converging etiopathogenetic pathways and early prevention opportunities for autism and neurodevelopmental disorders in the first 1000 days of life: a brief narrative review.Neuropsychiatrie : Klinik, Diagnostik, Therapie und Rehabilitation : Organ der Gesellschaft Osterreichischer Nervenarzte und Psychiater · 2026Review
- Comparative cross-sectional analysis of the Griffiths III and the Developmental Autism Early Screening (DAES) test in children with neurodevelopmental disorders.BMC psychiatry · 2026Article
- Ethno-evolutionary insights and missed critical periods hypothesis of Autism Spectrum Condition.Frontiers in child and adolescent psychiatry · 2026Article
- Feasibility and preliminary efficacy of an infant preemptive intervention for prodromes of autism spectrum disorder (ASD) delivered within an Italian tertiary hospital.Frontiers in child and adolescent psychiatry · 2026Article
- Research on the severity of symptoms in children with ASD based on integrated machine learning and structural equation modeling: age-specific predictive features and mediation effect path analysis.Frontiers in pediatrics · 2026Article
- Parent-mediated early intervention in infants and toddlers at elevated likelihood for autism: a systematic review of randomized controlled trials.Frontiers in psychiatry · 2026Review
- The Quality of the Parent-Child Relationship in the Context of Autism: The Role of Parental Resolution of the Child's Diagnosis, Parenting Stress, and Caregiving Burden.European journal of investigation in health, psychology and education · 2025Article
- The Psychometric Properties of the Iranian Version of Repetitive Behavior Scale-Revised (RBS-R) Questionnaire in Children With Autism Spectrum Disorder.Health science reports · 2025Article
- The Use of Griffiths III in the Appraisal of the Developmental Profile in Autism: A Systematic Search and Review.Brain sciences · 2025Review
- Early Recognition and Intervention in SIBlingS at High Risk for Neurodevelopment Disorders (ERI-SIBS): a controlled trial of an innovative and ecological intervention for siblings of children with autism spectrum disorder.Frontiers in pediatrics · 2024Article
- Editorial: Psychometrics in Psychiatry 2022: Autism.Frontiers in psychiatry · 2024Article
- Interactive mirrOring Games wIth sOCial rObot (IOGIOCO): a pilot study on the use of intransitive gestures in a sample of Italian preschool children with autism spectrum disorder.Frontiers in psychiatry · 2024Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Autism spectrum disorder (ASD) includes neurodevelopmental conditions traditionally considered to bring life long disabilities, severely impacting individuals and their families. Very early identification and intervention during the very first phases of life have shown to significantly diminish symptom severity and disability, and improve developmental trajectories. Here we report the case of a young child showing early behavioral signs of ASD during the first months of life, including diminished eye contact, reduced social reciprocity, repetitive movements. The child received a pre-emptive parent mediated intervention based on the Infant Start, an adaptation of the Early Start Denver Model (ESDM), specifically developed for children with ASD signs during the first year of life. The child here described received intervention from 6 to 32 months of age, in combination with educational services. Diagnostic evaluations performed at several time points (8, 14, 19, and 32 months) showed progressive improvements in his developmental level and ASD symptoms. Our case study supports the possibility of identifying ASD symptoms and providing services as soon as concerns emerge even during the first year of life. Our report, in combination with recent infant identification and intervention studies, suggests the need for very early screening and preemptive intervention to promote optimal outcomes.
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