Evidence map›Paper›PMID 37205955›Full record

ArticleJPGN reports2021

Acute Liver Failure in a Healthy Young Female With COVID-19.

Babak John Orandi, Geling Li, Deepti Dhall, Prachi Bajpai, Upender Manne, Nitin Arora, Ailing Lu, Ana Carolina Coronado, Rachel Kassel, Swetha Pinninti and 4 more

Open access · hybridAbstract readCase Reports
In one paragraph

Article in JPGN reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Review
  5. Review
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 1 institution in 1 country.

Babak John OrandiFrom the Department of Surgery, University of Alabama at Birmingham, Birmingham, AL.
Geling LiDepartment of Pathology, University of Alabama at Birmingham, Birmingham, AL.
Deepti DhallDepartment of Pathology, University of Alabama at Birmingham, Birmingham, AL.
Prachi BajpaiDepartment of Pathology, University of Alabama at Birmingham, Birmingham, AL.
Upender ManneDepartment of Pathology, University of Alabama at Birmingham, Birmingham, AL.
Nitin AroraDivision of Neonatology, Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL.
Ailing LuDivision of Neonatology, Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL.
Ana Carolina CoronadoDivision of Pediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL.
Rachel KasselDivision of Pediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL.
Swetha PinnintiDivision of Pediatric Infectious Diseases, Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL.
Cora Elizabeth LewisDepartment of Epidemiology, University of Alabama at Birmingham, Birmingham, AL.
Christopher ChapleauDepartment of Pharmacy, University of Alabama, at Birmingham, Birmingham, AL.
Jayme Elizabeth LockeFrom the Department of Surgery, University of Alabama at Birmingham, Birmingham, AL.
Luz Helena Gutierrez SanchezDivision of Pediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL.
University of Alabama at Birmingham · US

Funding

DEEP SOUTH TRANSLATIONAL RESEARCH MENTORED CAREER DEVELOPMENT PROGRAMKL2TR003097 · NCATS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI SAAG, KENNETH G · 2019 to 2023
$5.2M
NCATS NIH HHS KL2 TR003097
6 · The paper itself

Abstract

Several well-described manifestations of infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been reported. Among them, a transient elevation of liver enzymes is the typical presentation of coronavirus disease 2019 (COVID-19) liver-related injury. The mechanism of liver involvement is likely a combination of viral injury and immune-mediated inflammation. In contrast, acute liver failure in the setting of COVID-19 has rarely been reported. Herein, we report a case of pediatric acute liver failure in a previously healthy female adolescent infected with SARS-CoV-2 with biopsy evidence of replicating virus in hepatocytes, which has not been previously reported.

Indexed as

acute liver failureCOVID-19liver transplant

Identifiers

PMID37205955
PMCPMC10191572
OpenAlexW3185672491

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.