Evidence map›Paper›PMID 37205586›Full record

ArticlebioRxiv : the preprint server for biology2023

Dopamine D2 receptors in mossy cells reduce excitatory transmission and are essential for hippocampal function.

Michelle C Gulfo, Joseph J Lebowitz, Czarina Ramos, Dong-Woo Hwang, Kaoutsar Nasrallah, Pablo E Castillo

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Michelle C GulfoDominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, U.S.A.
Joseph J LebowitzVollum Institute, Oregon Health and Science University, Portland, OR 97239, U.S.A.
Czarina RamosDominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, U.S.A.
Dong-Woo HwangDepartment of Cell Biology, Albert Einstein College of Medicine, Bronx, NY 10461, U.S.A.
Kaoutsar NasrallahDominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, U.S.A.
Pablo E CastilloDominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, U.S.A.
Albert Einstein College of Medicine · USOregon Health & Science University · US

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007288 · NIGMS · YESHIVA UNIVERSITY · PI AKABAS, MYLES H. · 1985 to 2022
$35.6M
BIOLOGICAL BASES OF DRUG-SEEKING BEHAVIORT32DA007262 · NIDA · OREGON HEALTH & SCIENCE UNIVERSITY · PI WILLIAMS, JOHN T · 1991 to 2022
$9.4M
COCAINE: EFFECTS ON SINGLE NEURONSR01DA004523 · NIDA · OREGON HEALTH & SCIENCE UNIVERSITY · PI WILLIAMS, JOHN T · 1987 to 2025
$7.6M
Presynaptic forms of long-term plasticity in the CNSR01MH125772 · NIMH · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI PABLO E CASTILLO · 2020 to 2026
$3.6M
Synaptic Mechanisms for Contextual Memory FormationR01MH116673 · NIMH · UPSTATE MEDICAL UNIVERSITY · PI CASTILLO, PABLO E, LIN, YINGXI · 2019 to 2023
$3.4M
Activity-Dependent Transcriptional Pathways Underlying Synaptic Mechanisms for Memory Discrimination and Generalization.R01NS115543 · NINDS · UT SOUTHWESTERN MEDICAL CENTER · PI CASTILLO, PABLO E, LIN, YINGXI · 2020 to 2024
$3.0M
Activity-Dependent Plasticity in an Associative Hippocampal Circuit: Mechanisms, Synaptic Learning Rules and Involvement in DiseaseR01NS113600 · NINDS · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI CASTILLO, PABLO E · 2019 to 2023
$2.7M
Following mRNA from birth to death at single-molecule resolutionR35GM136296 · NIGMS · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI SINGER, ROBERT H · 2020 to 2024
$2.3M
Zeiss Confocal Microscope with Airyscan for Einstein Neural Cell Engineering and Imaging CoreS10OD025295 · OD · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI DOBRENIS, KOSTANTIN · 2019 to 2019
$523k
Assessing dopaminergic modulation of an associative circuit within the dentate gyrusF31MH122134 · NIMH · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI GULFO, MICHELLE C · 2019 to 2021
$137k
NIDA NIH HHS R01 DA004523NIDA NIH HHS T32 DA007262NIGMS NIH HHS R35 GM136296NIH HHS S10 OD025295NIMH NIH HHS F31 MH122134NIMH NIH HHS R01 MH116673NIMH NIH HHS R01 MH125772NINDS NIH HHS R01 NS113600NINDS NIH HHS R01 NS115543
6 · The paper itself

Abstract

Hilar mossy cells (MCs) are principal excitatory neurons of the dentate gyrus (DG) that play critical roles in hippocampal function and have been implicated in brain disorders such as anxiety and epilepsy. However, the mechanisms by which MCs contribute to DG function and disease are poorly understood. Expression from the dopamine D2 receptor (D2R) gene (

Indexed as

anxietyD2 receptordentate gyrusdopamineHippocampusmossy cellseizuresspatial memorytemporal lobe epilepsy

Identifiers

PMID37205586
PMCPMC10187294
OpenAlexW4372194116

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.