Evidence map›Paper›PMID 37205554›Full record

ArticlebioRxiv : the preprint server for biology2023

CWHM-974 is a fluphenazine derivative with improved antifungal activity against

Aracely Miron-Ocampo, Sarah R Beattie, Soumitra Guin, Thomas Conway, Marvin J Meyers, W Scott Moye-Rowley, Damian J Krysan

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Aracely Miron-OcampoMicrobiology/Immunology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242.
Sarah R BeattieDepartment of Pediatrics Carver College of Medicine, University of Iowa, Iowa City, IA 52242.
Soumitra GuinDepartment of Chemistry, Saint Louis University, Saint Louis MO.
Thomas ConwayDepartment of Molecular Physiology and Biophysics, University of Iowa, Iowa City IA 52242.
Marvin J MeyersDepartment of Chemistry, Saint Louis University, Saint Louis MO.
W Scott Moye-RowleyDepartment of Molecular Physiology and Biophysics, University of Iowa, Iowa City IA 52242.
Damian J KrysanMicrobiology/Immunology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242.
University of Iowa · USSaint Louis University · US

Funding

Hit-to-lead optimization of broad spectrum antifungal phenothiazinesR21AI164578 · NIAID · UNIVERSITY OF IOWA · PI KRYSAN, DAMIAN J, MEYERS, MARVIN J · 2021 to 2022
$434k
Development of a high throughput-compatible assay for screening filamentous fungiF32AI145160 · NIAID · UNIVERSITY OF IOWA · PI BEATTIE, SARAH R. · 2020 to 2022
$185k
NIAID NIH HHS F32 AI145160NIAID NIH HHS R21 AI164578
6 · The paper itself

Abstract

Multidrug resistance (MDR) transporters such as ATP Binding Cassette (ABC) and Major Facilitator Superfamily (MFS) proteins are important mediators of antifungal drug resistance, particularly with respect to azole class drugs. Consequently, identifying molecules that are not susceptible to this mechanism of resistance is an important goal for new antifungal drug discovery. As part of a project to optimize the antifungal activity of clinically used phenothiazines, we synthesized a fluphenazine derivative (CWHM-974) with 8-fold higher activity against

Identifiers

PMID37205554
PMCPMC10187223
OpenAlexW4367679585

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.