Evidence map›Paper›PMID 37205543›Full record

ArticlebioRxiv : the preprint server for biology2023

Chronic alcohol consumption dysregulates innate immune response to SARS-CoV-2 in the lung.

Sloan A Lewis, Isaac R Cinco, Brianna M Doratt, Madison B Blanton, Cherise Hoagland, Michael Davies, Kathleen A Grant, Ilhem Messaoudi

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Sloan A LewisDepartment of Molecular Biology and Biochemistry, School of Biological Sciences, University of California Irvine.
Isaac R CincoMicrobiology, Immunology and Molecular Genetics, College of Medicine, University of Kentucky.
Brianna M DorattMicrobiology, Immunology and Molecular Genetics, College of Medicine, University of Kentucky.
Madison B BlantonMicrobiology, Immunology and Molecular Genetics, College of Medicine, University of Kentucky.
Cherise HoaglandDivision of Neuroscience, Oregon National Primate Research Center, Oregon Health and Science University.
Michael DaviesDivision of Neuroscience, Oregon National Primate Research Center, Oregon Health and Science University.
Kathleen A GrantDivision of Neuroscience, Oregon National Primate Research Center, Oregon Health and Science University.
Ilhem MessaoudiMicrobiology, Immunology and Molecular Genetics, College of Medicine, University of Kentucky.
University of Kentucky · USOregon National Primate Research Center · USUniversity of California, Irvine · US

Funding

Upgrade of confocal microscopy at the Oregon National Primate Research CenterP51OD011092 · OD · OREGON HEALTH & SCIENCE UNIVERSITY · PI Bonnie J. Nagel · 2012 to 2026
$203.9M
NIH HHS P51 OD011092
6 · The paper itself

Abstract

Alcohol consumption is widespread with over half of the individuals over 18 years of age in the U.S. reporting alcohol use in the last 30 days. Moreover, 9 million Americans engaged in binge or chronic heavy drinking (CHD) in 2019. CHD negatively impacts pathogen clearance and tissue repair, including in the respiratory tract, thereby increasing susceptibility to infection. Although, it has been hypothesized that chronic alcohol consumption negatively impacts COVID-19 outcomes; the interplay between chronic alcohol use and SARS-CoV-2 infection outcomes has yet to be elucidated. Therefore, in this study we investigated the impact of chronic alcohol consumption on SARS-CoV-2 anti-viral responses in bronchoalveolar lavage cell samples from humans with alcohol use disorder and rhesus macaques that engaged in chronic drinking. Our data show that in both humans and macaques, the induction of key antiviral cytokines and growth factors was decreased with chronic ethanol consumption. Moreover, in macaques fewer differentially expressed genes mapped to Gene Ontology terms associated with antiviral immunity following 6 month of ethanol consumption while TLR signaling pathways were upregulated. These data are indicative of aberrant inflammation and reduced antiviral responses in the lung with chronic alcohol drinking.

Identifiers

PMID37205543
PMCPMC10187161
OpenAlexW4367837109

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.