ArticleResearch square2023
Prolonged activation of EP3 receptor-expressing preoptic neurons underlies torpor responses.
Natalia L S Machado, Francesca Raffin, Satvinder Kaur, Alexander S Banks, Nicole Lynch, Oleksandra Fanari, Oscar R Plascencia, Sydney Aten, Janayna D Lima, Sathyajit S Bandaru and 3 more
Open access · greenAbstract readPreprint
In one paragraphArticle in Research square, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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0citing papers in PubMed
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
0 citing papers in PubMed, 8 citations in OpenAlex.
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4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
13 authors at 3 institutions in 2 countries.
Natalia L S MachadoDepartment of Neurology, Beth Israel-Deaconess Medical Center and Harvard Medical School, Blackfan circle, Boston 02215 USA.ORCID 0000-0001-8750-2676 Francesca RaffinDepartment of Neurology, Beth Israel-Deaconess Medical Center and Harvard Medical School, Blackfan circle, Boston 02215 USA.
Satvinder KaurDepartment of Neurology, Beth Israel-Deaconess Medical Center and Harvard Medical School, Blackfan circle, Boston 02215 USA.ORCID 0000-0002-8243-2880 Alexander S BanksDivision of Endocrinology, Metabolism, and Diabetes, Beth Israel-Deaconess Medical Center and Harvard Medical School, Boston 02215 USA.
Nicole LynchDepartment of Neurology, Beth Israel-Deaconess Medical Center and Harvard Medical School, Blackfan circle, Boston 02215 USA.
Oleksandra FanariDepartment of Neurology, Beth Israel-Deaconess Medical Center and Harvard Medical School, Blackfan circle, Boston 02215 USA.ORCID 0009-0003-2915-859X Oscar R PlascenciaDepartment of Neurology, Beth Israel-Deaconess Medical Center and Harvard Medical School, Blackfan circle, Boston 02215 USA.
Sydney AtenDepartment of Neurology, Beth Israel-Deaconess Medical Center and Harvard Medical School, Blackfan circle, Boston 02215 USA.
Janayna D LimaDepartment of Neurology, Beth Israel-Deaconess Medical Center and Harvard Medical School, Blackfan circle, Boston 02215 USA.
Sathyajit S BandaruDepartment of Neurology, Beth Israel-Deaconess Medical Center and Harvard Medical School, Blackfan circle, Boston 02215 USA.
Richard D PalmiterHoward Hughes Medical Institute and Department of Biochemistry, University of Washington, 1959 NE Pacific St., Seattle WA 98195-7370 USA.ORCID 0000-0001-6587-0582 Elda ArrigoniDepartment of Neurology, Beth Israel-Deaconess Medical Center and Harvard Medical School, Blackfan circle, Boston 02215 USA.
Clifford B SaperDepartment of Neurology, Beth Israel-Deaconess Medical Center and Harvard Medical School, Blackfan circle, Boston 02215 USA.ORCID 0000-0002-5788-3014 Harvard University · USBeth Israel Deaconess Medical Center · USHoward Hughes Medical Institute · US
Funding
ROLE OF DIETARY CONSTITUENTS ON GENE EXPRESSION IN INTESTINAL EPITHELIUMP30DK040561 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Elizabeth Austen Lawson, Takara Leah Stanley · 1994 to 2026
$31.6MWakefulness and Forebrain Activation by Orexin NeuronsP01HL095491 · NHLBI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI WELLMAN, DAVID ANDREW · 2010 to 2019
$25.1MTransgenic CoreP30DK046200 · NIDDK · TUFTS MEDICAL CENTER · PI CORKEY, BARBARA E. · 1992 to 2021
$25.0MHypothalamic arousal systemsR01NS085477 · NINDS · BETH ISRAEL DEACONESS MEDICAL CENTER · PI SAPER, CLIFFORD B · 2014 to 2018
$2.8MDissection of the Circuitry Regulating Arousal to PainR01NS112175 · NINDS · BETH ISRAEL DEACONESS MEDICAL CENTER · PI KAUR, SATVINDER · 2019 to 2023
$1.9MNeuronal Circuit Controlling Sleep-Promoting Ventrolateral Preoptic NeuronsR01NS122589 · NINDS · BETH ISRAEL DEACONESS MEDICAL CENTER · PI Elda Arrigoni · 2022 to 2026
$1.8MInstrumentation for Noninvasive Measurement of Glucose and Energy Balance in Mice with Continuous Glucose Telemetry and Indirect CalorimetryS10OD028635 · OD · BETH ISRAEL DEACONESS MEDICAL CENTER · PI BANKS, ALEXANDER · 2020 to 2020
$737kNHLBI NIH HHS P01 HL095491NIDDK NIH HHS P30 DK040561NIDDK NIH HHS P30 DK046200NIH HHS S10 OD028635NINDS NIH HHS R01 NS085477NINDS NIH HHS R01 NS112175NINDS NIH HHS R01 NS122589
6 · The paper itselfAbstract
Many species use a temporary drop in body temperature and metabolic rate (torpor) as a strategy to survive food scarcity. A similar profound hypothermia is observed with activation of preoptic neurons that express the neuropeptides Pituitary Adenylate-Cyclase-Activating Polypeptide (PACAP)
Identifiers
PMID37205518
PMCPMC10187418
OpenAlexW4367680377
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