Evidence map›Paper›PMID 37205482›Full record

ArticlebioRxiv : the preprint server for biology2023

ADARs employ a neural-specific mechanism to regulate PQM-1 expression and survival from hypoxia.

Ananya Mahapatra, Alfa Dhakal, Aika Noguchi, Pranathi Vadlamani, Heather A Hundley

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Ananya MahapatraGenome, Cell and Developmental Biology Graduate Program, Indiana University, Bloomington IN, 47405 USA.
Alfa DhakalCell, Molecular and Cancer Biology Graduate Program, Indiana University School of Medicine - Bloomington, Bloomington IN, 47405 USA.
Aika NoguchiDepartment of Biology, Indiana University, Bloomington IN 47405 USA.
Pranathi VadlamaniMedical Sciences Program, Indiana University School of Medicine - Bloomington, Bloomington IN, 47405 USA.
Heather A HundleyDepartment of Biology, Indiana University, Bloomington IN 47405 USA.
Indiana University Bloomington · US

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Aric L Daul, Ann E. Rougvie · 2012 to 2026
$7.5M
Molecular mechanisms that regulate ADAR target recognition and RNA editing in vivoR01GM130759 · NIGMS · TRUSTEES OF INDIANA UNIVERSITY · PI HUNDLEY, HEATHER ANN · 2019 to 2023
$1.8M
NIGMS NIH HHS R01 GM130759NIH HHS P40 OD010440
6 · The paper itself

Abstract

The ability to alter gene expression programs in response to changes in environmental conditions is central to the ability of an organism to thrive. For most organisms, the nervous system serves as the master regulator in communicating information about the animal's surroundings to other tissues. The information relay centers on signaling pathways that cue transcription factors in a given cell type to execute a specific gene expression program, but also provide a means to signal between tissues. The transcription factor PQM-1 is an important mediator of the insulin signaling pathway contributing to longevity and the stress response as well as impacting survival from hypoxia. Herein, we reveal a novel mechanism for regulating PQM-1 expression specifically in neural cells of larval animals. Our studies reveal that the RNA binding protein, ADR-1, binds to

Identifiers

PMID37205482
PMCPMC10187282
OpenAlexW4372250833

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.