Evidence map›Paper›PMID 37205475›Full record

ArticlebioRxiv : the preprint server for biology2023

Integrative multi-dimensional characterization of striatal projection neuron heterogeneity in adult brain.

Jenesis Gayden, Stephanie Puig, Chaitanya Srinivasan, BaDoi N Phan, Ghada Abdelhady, Silas A Buck, Mackenzie C Gamble, Hugo A Tejeda, Yan Dong, Andreas R Pfenning and 2 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 14 citations in OpenAlex.

  1. Interaction Between Oxytocin and Dopamine Signaling: Focus on the Striatum.International journal of molecular sciences · 2025
    Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 1 country.

Jenesis GaydenCenter for Neuroscience, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Stephanie PuigDepartment of Psychiatry, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.
Chaitanya SrinivasanDepartment of Computational Biology, Carnegie Mellon University, Pittsburgh, PA 15213, USA.
BaDoi N PhanDepartment of Computational Biology, Carnegie Mellon University, Pittsburgh, PA 15213, USA.
Ghada AbdelhadyCenter for Neuroscience, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Silas A BuckCenter for Neuroscience, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Mackenzie C GambleDepartment of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, Boston, MA, USA.
Hugo A TejedaUnit on Neuromodulation and Synaptic Integration, National Institute of Mental Health, Bethesda, MD 20894, USA.
Yan DongDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Andreas R PfenningDepartment of Computational Biology, Carnegie Mellon University, Pittsburgh, PA 15213, USA.
Ryan W LoganDepartment of Psychiatry, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.
Zachary FreybergDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA.
University of Pittsburgh · USCarnegie Mellon University · USUniversity of Massachusetts Chan Medical School · USBoston University · USNational Institute of Mental Health · USUniversity of Pittsburgh Medical Center · US

Funding

Predoctorial Training in Basic NeuroscienceT32NS007433 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MERINEY, STEPHEN D · 1998 to 2022
$8.0M
Glial-mediated synaptic remodeling in drug addictionR01DA040620 · NIDA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Yan Dong, ERIC J. NESTLER · 2016 to 2026
$5.3M
Cocaine-induced adaptation in NMDA receptorsR37DA023206 · NIDA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Yan Dong · 2018 to 2026
$3.9M
Cocaine-induced Adaptation in NMDA Receptors in Nucleus AccumbensR01DA023206 · NIDA · WASHINGTON STATE UNIVERSITY · PI DONG, YAN · 2008 to 2017
$3.0M
Interpreting the regulatory mechanisms underlying the predisposition to substance use disordersDP1DA046585 · NIDA · CARNEGIE-MELLON UNIVERSITY · PI PFENNING, ANDREAS ROBERT · 2018 to 2022
$2.4M
Novel roles of VGLUT in sex differences in dopamine neuron vulnerability to environmental toxicant-induced neurodegenerationR01ES034037 · NIEHS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ZACHARY FREYBERG · 2023 to 2026
$2.3M
Interinstitutional Program in Cell and Molecular Biology: A Graduate Training Path to Promote Traditional and Non-Traditional Professional OutcomesT32GM133353 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BRODSKY, JEFFREY L., MURRAY, SANDRA ANN · 2020 to 2024
$1.5M
Ultra-fast high-resolution imaging of whole mouse brain for the study of drug addictionR21DA052419 · NIDA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FREYBERG, ZACHARY, LOGAN, RYAN W · 2021 to 2022
$448k
A novel role for midbrain glutamate co-transmitting neurons in alcohol drinking and motivated behaviorsR21AA028800 · NIAAA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FREYBERG, ZACHARY, LOGAN, RYAN W · 2021 to 2022
$446k
Mechanisms for Preserving Neurons in Alzheimer's Disease-Related Dementias Across Drosophila and Mouse ModelsR21AG068607 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FREYBERG, ZACHARY · 2020 to 2021
$430k
Integrating primate-rodent cell types and epigenomics to identify conservation in substance addictionF30DA053020 · NIDA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI PHAN, BADOI NGUYEN · 2021 to 2024
$204k
Dissecting the functional relevance of unique subpopulations of striatal dopamine receptors in opioid use disorderR36DA057972 · NIDA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KOZEL, JENESIS · 2023 to 2024
$108k
NIAAA NIH HHS R21 AA028800NIA NIH HHS R21 AG068607NIDA NIH HHS DP1 DA046585NIDA NIH HHS F30 DA053020NIDA NIH HHS R01 DA023206NIDA NIH HHS R01 DA040620NIDA NIH HHS R21 DA052419NIDA NIH HHS R36 DA057972NIDA NIH HHS R37 DA023206NIEHS NIH HHS R01 ES034037NIGMS NIH HHS T32 GM133353NINDS NIH HHS T32 NS007433
6 · The paper itself

Abstract

Striatal projection neurons (SPNs) are traditionally segregated into two subpopulations expressing dopamine (DA) D

Indexed as

DopamineRNAscopeRNAseqstriatumtranscriptomics

Identifiers

PMID37205475
PMCPMC10187292
OpenAlexW4372404257

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.