Evidence map›Paper›PMID 37205464›Full record

ArticlebioRxiv : the preprint server for biology2023

Apoptotic signaling clears engineered

Taylor J Abele, Zachary P Billman, Lupeng Li, Carissa K Harvest, Alexia K Bryan, Gabrielle R Magalski, Joseph P Lopez, Heather N Larson, Xiao-Ming Yin, Edward A Miao

Open access · greenAbstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Zachary P Billman
Lupeng Li
Carissa K Harvest
Alexia K Bryan
Gabrielle R Magalski
Joseph P Lopez
Heather N Larson
Xiao-Ming Yin
Edward A Miao
Duke University · USUniversity of North Carolina at Chapel Hill · USTulane University · US

Funding

Innate immune defenses against a cytosolic capsuleR01AI136920 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Edward A Miao · 2019 to 2026
$3.7M
Pyroptosis maintains the integrity of a granulomaR01AI175078 · NIAID · DUKE UNIVERSITY · PI Edward A Miao · 2023 to 2026
$2.6M
Intestinal epithelial cell exfoliation by caspasesR01AI139304 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MIAO, EDWARD A · 2018 to 2022
$2.2M
Natural killer cell cytotoxicity against intracellular bacteriaR01AI133236 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MIAO, EDWARD A · 2018 to 2022
$2.2M
Membrane repair boosted by caspase signalingR01AI181815 · NIAID · DUKE UNIVERSITY · PI Edward A Miao · 2024 to 2026
$1.9M
NIAID NIH HHS R01 AI133236NIAID NIH HHS R01 AI136920NIAID NIH HHS R01 AI139304NIAID NIH HHS R01 AI175078NIAID NIH HHS R01 AI181815
6 · The paper itself

Abstract

Pyroptosis and apoptosis are two forms of regulated cell death that can defend against intracellular infection. Although pyroptosis and apoptosis have distinct signaling pathways, when a cell fails to complete pyroptosis, backup pathways will initiate apoptosis. Here, we investigated the utility of apoptosis compared to pyroptosis in defense against an intracellular bacterial infection. We previously engineered

Identifiers

PMID37205464
PMCPMC10187329
OpenAlexW4372316675

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.