Evidence map›Paper›PMID 37205462›Full record

ArticlebioRxiv : the preprint server for biology2023

Lactate transporter MCT1 in hepatic stellate cells promotes fibrotic collagen expression in nonalcoholic steatohepatitis.

Kyounghee Min, Batuhan Yenilmez, Mark Kelly, Dimas Echeverria, Michael Elleby, Lawrence M Lifshitz, Naideline Raymond, Emmanouela Tsagkaraki, Shauna M Harney, Chloe DiMarzio and 7 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors.

Kyounghee MinProgram in Molecular Medicine, University of Massachusetts Chan Medical School, USA.
Batuhan YenilmezProgram in Molecular Medicine, University of Massachusetts Chan Medical School, USA.
Mark KellyProgram in Molecular Medicine, University of Massachusetts Chan Medical School, USA.
Dimas EcheverriaRNA Therapeutics Institute, University of Massachusetts Chan Medical School, USA.
Michael EllebyProgram in Molecular Medicine, University of Massachusetts Chan Medical School, USA.
Lawrence M LifshitzProgram in Molecular Medicine, University of Massachusetts Chan Medical School, USA.
Naideline RaymondProgram in Molecular Medicine, University of Massachusetts Chan Medical School, USA.
Emmanouela TsagkarakiProgram in Molecular Medicine, University of Massachusetts Chan Medical School, USA.
Shauna M HarneyProgram in Molecular Medicine, University of Massachusetts Chan Medical School, USA.
Chloe DiMarzioProgram in Molecular Medicine, University of Massachusetts Chan Medical School, USA.
Hui WangProgram in Molecular Medicine, University of Massachusetts Chan Medical School, USA.
Nicholas McHughRNA Therapeutics Institute, University of Massachusetts Chan Medical School, USA.
Brianna BramatoRNA Therapeutics Institute, University of Massachusetts Chan Medical School, USA.
Brett MorrisionDepartment of Neurology, Johns Hopkins School of Medicine, USA.
Jeffery D RothsteinDepartment of Neurology, Johns Hopkins School of Medicine, USA.
Anastasia KhvorovaRNA Therapeutics Institute, University of Massachusetts Chan Medical School, USA.
Michael P CzechProgram in Molecular Medicine, University of Massachusetts Chan Medical School, USA.

Funding

Insulin Signaling and Metabolic Regulation in AdipocytesR37DK030898 · NIDDK · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI CZECH, MICHAEL P · 1996 to 2021
$7.2M
Paracrine Signaling by Kupffer Cells in Hepatic Insulin ResistanceR01DK103047 · NIDDK · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI CZECH, MICHAEL P · 2015 to 2023
$5.0M
Adipocyte to neuron signaling in thermogenic programming of white adipose tissueR01DK116056 · NIDDK · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI CZECH, MICHAEL P · 2019 to 2023
$2.9M
Insulin Signaling and Metabolic Regulation in AdipocytesR01DK030898 · NIDDK · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI CZECH, MICHAEL P · 1986 to 2011
$2.7M
NIDDK NIH HHS R01 DK030898NIDDK NIH HHS R01 DK103047NIDDK NIH HHS R01 DK116056NIDDK NIH HHS R37 DK030898
6 · The paper itself

Abstract

Circulating lactate is a fuel source for liver metabolism but may exacerbate metabolic diseases such as nonalcoholic steatohepatitis (NASH). Indeed, haploinsufficiency of lactate transporter monocarboxylate transporter 1 (MCT1) in mice reportedly promotes resistance to hepatic steatosis and inflammation. Here, we used adeno-associated virus (AAV) vectors to deliver thyroxin binding globulin (TBG)-Cre or lecithin-retinol acyltransferase (Lrat)-Cre to MCT1

Identifiers

PMID37205462
PMCPMC10187148

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.