Evidence map›Paper›PMID 37205446›Full record

ArticlebioRxiv : the preprint server for biology2023

Boosting Live Malaria Vaccine with Cytomegalovirus Vector Can Prolong Immunity through Innate and Adaptive Mechanisms.

Komi Gbedande, Samad A Ibitokou, Monique L Ong, Mariapia A Degli-Esposti, Michael G Brown, Robin Stephens

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Komi GbedandeDepartment of Internal Medicine, Division of Infectious Diseases, University of Texas Medical Branch, Galveston, TX 77555-0435.
Samad A IbitokouDepartment of Internal Medicine, Division of Infectious Diseases, University of Texas Medical Branch, Galveston, TX 77555-0435.
Monique L OngCentre for Experimental Immunology, Lions Eye Institute; Nedlands, Western Australia, Australia.
Mariapia A Degli-EspostiCentre for Experimental Immunology, Lions Eye Institute; Nedlands, Western Australia, Australia.
Michael G BrownDepartment of Medicine, Division of Nephrology, and the Beirne B. Carter Center for Immunology Research, University of Virginia, Charlottesville, VA.
Robin StephensDepartment of Internal Medicine, Division of Infectious Diseases, University of Texas Medical Branch, Galveston, TX 77555-0435.
Lions Eye Institute · AURutgers, The State University of New Jersey · USCarter Center · USThe University of Texas Medical Branch at Galveston · US

Funding

The Germinal Center and T cell help in Three Phases of Clearance of PlasmodiumR01AI135061 · NIAID · UNIVERSITY OF TEXAS MED BR GALVESTON · PI STEPHENS, ROBIN · 2018 to 2022
$2.0M
Maintenance vs Programming in Th1 Memory Cell Development in P. Chabaudi MalariaR01AI089953 · NIAID · UNIVERSITY OF TEXAS MED BR GALVESTON · PI STEPHENS, ROBIN · 2011 to 2015
$1.8M
NIAID NIH HHS R01 AI089953NIAID NIH HHS R01 AI135061
6 · The paper itself

Abstract

Vaccines to persistent parasite infections have been challenging, and current iterations lack long-term protection. Cytomegalovirus (CMV) chronic vaccine vectors drive protection against SIV, tuberculosis and liver-stage malaria correlated with antigen-specific CD8 T cells with a Tem phenotype. This phenotype is likely driven by a combination of antigen-specific and innate adjuvanting effects of the vector, though these mechanisms are less well understood. Sterilizing immunity from live

Identifiers

PMID37205446
PMCPMC10187235
OpenAlexW4367671900

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.