Evidence map›Paper›PMID 37205437›Full record

ArticlebioRxiv : the preprint server for biology2023

Synergistic Binding of the Halide and Cationic Prime Substrate of the l-Lysine 4-Chlorinase, BesD, in Both Ferrous and Ferryl States.

Jeffrey W Slater, Monica E Neugebauer, Molly J McBride, Debangsu Sil, Chi-Yun Lin, Bryce J Katch, Amie K Boal, Michelle C Y Chang, Alexey Silakov, Carsten Krebs and 1 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Jeffrey W SlaterDepartment of Chemistry, The Pennsylvania State University, University Park, Pennsylvania 16802, United States.
Monica E NeugebauerDepartment of Chemical and Biomolecular Engineering, University of California, Berkeley, Berkeley, CA, USA.
Molly J McBrideDepartment of Chemistry, The Pennsylvania State University, University Park, Pennsylvania 16802, United States.
Debangsu SilDepartment of Chemistry, The Pennsylvania State University, University Park, Pennsylvania 16802, United States.
Chi-Yun LinDepartment of Chemistry, The Pennsylvania State University, University Park, Pennsylvania 16802, United States.
Bryce J KatchDepartment of Chemistry, The Pennsylvania State University, University Park, Pennsylvania 16802, United States.
Amie K BoalDepartment of Chemistry, The Pennsylvania State University, University Park, Pennsylvania 16802, United States.
Michelle C Y ChangDepartment of Chemical and Biomolecular Engineering, University of California, Berkeley, Berkeley, CA, USA.
Alexey SilakovDepartment of Chemistry, The Pennsylvania State University, University Park, Pennsylvania 16802, United States.
Carsten KrebsDepartment of Chemistry, The Pennsylvania State University, University Park, Pennsylvania 16802, United States.
J Martin BollingerDepartment of Chemistry, The Pennsylvania State University, University Park, Pennsylvania 16802, United States.
Pennsylvania State University · USHarvard University · USLawrence Berkeley National Laboratory · US

Funding

Mapping the Structural Basis for Mechanistic Diversity in Metalloenzyme SuperfamiliesR35GM119707 · NIGMS · PENNSYLVANIA STATE UNIVERSITY, THE · PI Amie K Boal · 2016 to 2026
$5.0M
Mechanisms of Mononuclear non-Heme-Iron EnzymesR35GM127079 · NIGMS · PENNSYLVANIA STATE UNIVERSITY, THE · PI CARSTEN KREBS · 2018 to 2026
$3.8M
Discovery and Application of New HalogenasesR01GM134271 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI CHANG, MICHELLE C · 2020 to 2023
$1.5M
The role of geometric structure in avoidance of oxygen rebound to enable aliphatic halogenation and oxacyclization by non-heme Fe(IV)-oxo (ferryl) complexesR01GM141284 · NIGMS · PENNSYLVANIA STATE UNIVERSITY, THE · PI SILAKOV, ALEXEY · 2022 to 2025
$1.5M
Structures and Mechanisms of “Heme-oxygenase-like” Non-heme Di-iron Enzymes that Catalyze Complex N-oxygenation and Olefin-installing C–C-Fragmentation ReactionsR01GM138580 · NIGMS · PENNSYLVANIA STATE UNIVERSITY, THE · PI BOLLINGER, JOSEPH M · 2020 to 2023
$1.3M
Interrogating the Haloferryl State of Iron(II)- and 2-Oxoglutarate-Dependent Halogenases through Mimicry and Active Site ModificationsF32GM136156 · NIGMS · PENNSYLVANIA STATE UNIVERSITY, THE · PI SLATER, JEFFREY WORTHINGTON · 2020 to 2022
$201k
NIGMS NIH HHS F32 GM136156NIGMS NIH HHS R01 GM134271NIGMS NIH HHS R01 GM138580NIGMS NIH HHS R01 GM141284NIGMS NIH HHS R35 GM119707NIGMS NIH HHS R35 GM127079
6 · The paper itself

Abstract

An aliphatic halogenase requires four substrates: 2-oxoglutarate (2OG), halide (Cl

Identifiers

PMID37205437
PMCPMC10187165
OpenAlexW4367845531

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.