Evidence map›Paper›PMID 37205403›Full record

ArticlebioRxiv : the preprint server for biology2023

Collection of Biospecimens from the Inspiration4 Mission Establishes the Standards for the Space Omics and Medical Atlas (SOMA).

Eliah G Overbey, Krista Ryon, JangKeun Kim, Braden Tierney, Remi Klotz, Veronica Ortiz, Sean Mullane, Julian C Schmidt, Matthew MacKay, Namita Damle and 19 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 4 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

29 authors at 6 institutions in 3 countries.

Eliah G OverbeyDepartment of Physiology and Biophysics, Weill Cornell Medicine, Cornell University, New York, NY, USA.
Krista RyonDepartment of Physiology and Biophysics, Weill Cornell Medicine, Cornell University, New York, NY, USA.
JangKeun KimDepartment of Physiology and Biophysics, Weill Cornell Medicine, Cornell University, New York, NY, USA.
Braden TierneyDepartment of Physiology and Biophysics, Weill Cornell Medicine, Cornell University, New York, NY, USA.
Remi KlotzDepartment of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Veronica OrtizDepartment of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Sean MullaneSpace Exploration Technologies Corporation, Hawthorne, CA, USA.
Julian C SchmidtSovaris Aerospace, Boulder, Colorado, USA.
Matthew MacKayDepartment of Physiology and Biophysics, Weill Cornell Medicine, Cornell University, New York, NY, USA.
Namita DamleDepartment of Physiology and Biophysics, Weill Cornell Medicine, Cornell University, New York, NY, USA.
Deena NajjarDepartment of Physiology and Biophysics, Weill Cornell Medicine, Cornell University, New York, NY, USA.
Irina MateiChildren's Cancer and Blood Foundation Laboratories, Departments of Pediatrics and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY.
Laura PatrasChildren's Cancer and Blood Foundation Laboratories, Departments of Pediatrics and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY.
J Sebastian Garcia MedinaDepartment of Physiology and Biophysics, Weill Cornell Medicine, Cornell University, New York, NY, USA.
Ashley KleinmanDepartment of Physiology and Biophysics, Weill Cornell Medicine, Cornell University, New York, NY, USA.
Jeremy Wain HirschbergDepartment of Physiology and Biophysics, Weill Cornell Medicine, Cornell University, New York, NY, USA.
Jacqueline ProszynskiDepartment of Physiology and Biophysics, Weill Cornell Medicine, Cornell University, New York, NY, USA.
S Anand NarayananFlorida State University College of Medicine, Tallahassee, Florida.
Caleb M SchmidtSovaris Aerospace, Boulder, Colorado, USA.
Evan E AfshinDepartment of Physiology and Biophysics, Weill Cornell Medicine, Cornell University, New York, NY, USA.
Lucinda InnesDepartment of Physiology and Biophysics, Weill Cornell Medicine, Cornell University, New York, NY, USA.
Mateo Mejia SaldarriagaHematology and Oncology Division, Weill Cornell Medicine, NY.
Michael A SchmidtSovaris Aerospace, Boulder, Colorado, USA.
Richard D GransteinDepartment of Dermatology, Weill Cornell Medicine, New York, NY.
Bader ShirahDepartment of Neuroscience, King Faisal Specialist Hospital & Research Centre, Jeddah, Saudi Arabia.
Min YuDepartment of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
David LydenChildren's Cancer and Blood Foundation Laboratories, Departments of Pediatrics and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY.
Jaime MateusSpace Exploration Technologies Corporation, Hawthorne, CA, USA.
Christopher E MasonDepartment of Physiology and Biophysics, Weill Cornell Medicine, Cornell University, New York, NY, USA.
Cornell University · USUniversity of Southern California · USSpaceX (United States) · USColorado State University · USFlorida State University · USKing Faisal Specialist Hospital & Research Centre · SA

Funding

The Spatiotemporal Landscape of the Human Brain EpitranscriptomeR01MH117406 · NIMH · WEILL MEDICAL COLL OF CORNELL UNIV · PI MASON, CHRISTOPHER EDWARD · 2018 to 2022
$3.3M
NIMH NIH HHS R01 MH117406
6 · The paper itself

Abstract

The SpaceX Inspiration4 mission provided a unique opportunity to study the impact of spaceflight on the human body. Biospecimen samples were collected from the crew at different stages of the mission, including before (L-92, L-44, L-3 days), during (FD1, FD2, FD3), and after (R+1, R+45, R+82, R+194 days) spaceflight, creating a longitudinal sample set. The collection process included samples such as venous blood, capillary dried blood spot cards, saliva, urine, stool, body swabs, capsule swabs, SpaceX Dragon capsule HEPA filter, and skin biopsies, which were processed to obtain aliquots of serum, plasma, extracellular vesicles, and peripheral blood mononuclear cells. All samples were then processed in clinical and research laboratories for optimal isolation and testing of DNA, RNA, proteins, metabolites, and other biomolecules. This paper describes the complete set of collected biospecimens, their processing steps, and long-term biobanking methods, which enable future molecular assays and testing. As such, this study details a robust framework for obtaining and preserving high-quality human, microbial, and environmental samples for aerospace medicine in the Space Omics and Medical Atlas (SOMA) initiative, which can also aid future experiments in human spaceflight and space biology.

Identifiers

PMID37205403
PMCPMC10187258
OpenAlexW4367670176

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.