Evidence map›Paper›PMID 37205387›Full record

ArticlebioRxiv : the preprint server for biology2023

Visualizing the chaperone-mediated folding trajectory of the G protein β5 β-propeller.

Shuxin Wang, Mikaila I Sass, Yujin Kwon, W Grant Ludlam, Theresa M Smith, Ethan J Carter, Nathan E Gladden, Margot Riggi, Janet H Iwasa, Barry M Willardson and 1 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Shuxin WangDepartment of Biochemistry, 15 N. Medical Drive East, University of Utah, Salt Lake City, UT, 84112, USA.
Mikaila I SassDepartment of Chemistry and Biochemistry, C100 BNSN, Brigham Young University, Provo, UT, 84602, USA.
Yujin KwonDepartment of Chemistry and Biochemistry, C100 BNSN, Brigham Young University, Provo, UT, 84602, USA.
W Grant LudlamDepartment of Chemistry and Biochemistry, C100 BNSN, Brigham Young University, Provo, UT, 84602, USA.
Theresa M SmithDepartment of Chemistry and Biochemistry, C100 BNSN, Brigham Young University, Provo, UT, 84602, USA.
Ethan J CarterDepartment of Chemistry and Biochemistry, C100 BNSN, Brigham Young University, Provo, UT, 84602, USA.
Nathan E GladdenDepartment of Chemistry and Biochemistry, C100 BNSN, Brigham Young University, Provo, UT, 84602, USA.
Margot RiggiDepartment of Biochemistry, 15 N. Medical Drive East, University of Utah, Salt Lake City, UT, 84112, USA.
Janet H IwasaDepartment of Biochemistry, 15 N. Medical Drive East, University of Utah, Salt Lake City, UT, 84112, USA.
Barry M WillardsonDepartment of Chemistry and Biochemistry, C100 BNSN, Brigham Young University, Provo, UT, 84602, USA.
Peter S ShenDepartment of Biochemistry, 15 N. Medical Drive East, University of Utah, Salt Lake City, UT, 84112, USA.
Brigham Young University · USUniversity of Utah · US

Funding

Structural basis for chaperone-dependent folding of beta-propeller proteins essential for visionR01EY012287 · NEI · BRIGHAM YOUNG UNIVERSITY · PI WILLARDSON, BARRY M · 1999 to 2022
$5.7M
Visualizing the Mechanisms of Protein Quality ControlR35GM133772 · NIGMS · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Peter Shen · 2019 to 2026
$3.4M
NEI NIH HHS R01 EY012287NIGMS NIH HHS R35 GM133772
6 · The paper itself

Abstract

The cytosolic Chaperonin Containing Tailless polypeptide 1 (CCT) complex is an essential protein folding machine with a diverse clientele of substrates, including many proteins with β-propeller domains. Here, we determined structures of CCT in complex with its accessory co-chaperone, phosducin-like protein 1 (PhLP1), in the process of folding Gβ

Identifiers

PMID37205387
PMCPMC10187262
OpenAlexW4372319338

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.