ArticleResearch square2026
Organoid modeling of lung-resident immune responses to SARS-CoV-2 infection.
Abstract readPreprint
In one paragraph
Article in Research square, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Immune organoids for Africa: a roadmap for bridging the innovation gap in infectious diseases and cancer research.Journal of the Egyptian National Cancer Institute · 2026Review
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
37 authors.
Joseph K RathkeyDepartment of Medicine, Divisions of Hematology, Stanford University School of Medicine, Stanford, CA 94305, USA.ORCID 0009-0004-5981-7469
Shannon S ChoiDepartment of Medicine, Divisions of Hematology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Vincent van UnenDepartment of Medicine, Divisions of Hematology, Stanford University School of Medicine, Stanford, CA 94305, USA.ORCID 0000-0001-9339-8430
Huimin ZhangDepartment of Medicine, Divisions of Hematology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Min LiuDepartment of Medicine, Divisions of Hematology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Jie DingDepartment of Medicine, Divisions of Hematology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Samira A AlwahabiDepartment of Medicine, Divisions of Hematology, Stanford University School of Medicine, Stanford, CA 94305, USA.
António J M SantosDepartment of Medicine, Divisions of Hematology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Vamsee MallajosyulaStanford Institute of Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford, CA 94305, USA.ORCID 0000-0002-0658-3652
Joshua E ChanDepartment of Medicine, Divisions of Hematology, Stanford University School of Medicine, Stanford, CA 94305, USA.ORCID 0000-0002-6016-1397
Azam MohsinDepartment of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Maher M ElsheikhDepartment of Medicine, Divisions of Hematology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Arjun RustagiInfectious Disease and Geographic Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.ORCID 0000-0002-6921-1012
Brandon LamDepartment of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Steven M ChirieleisonDepartment of Medicine, Divisions of Hematology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Bailey WallenDepartment of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA.
Daniel SolisDepartment of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Jordan MahDepartment of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Hudson T HornDepartment of Medicine, Divisions of Hematology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Katharina RöltgenDepartment of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA.ORCID 0000-0002-1582-1720
Ramesh NairDepartment of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA.
Winston TropeDepartment of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA.
Alexander Guh-SieselDepartment of Medicine, Divisions of Hematology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Zhongqi LinDepartment of Medicine, Divisions of Hematology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Aimee BeckInfectious Disease and Geographic Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
Caitlin EdwardsDepartment of Microbiology and Immunology, University of North Carolina Chapel Hill, Chapel Hill, NC 27599, USA.ORCID 0000-0003-4228-2192
Brock A MartinDepartment of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA.
James C Y DunnDepartment of Pediatric Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA.ORCID 0000-0002-6826-7065
Joseph ShragerDepartment of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA.ORCID 0000-0003-0859-0589
Ralph A BaricDepartment of Microbiology and Immunology, University of North Carolina Chapel Hill, Chapel Hill, NC 27599, USA.ORCID 0000-0001-6827-8701
Benjamin PinskyDepartment of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA.ORCID 0000-0001-8751-4810
Scott D BoydDepartment of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA.ORCID 0000-0003-0963-044X
Catherine A BlishStanford Institute of Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford, CA 94305, USA.ORCID 0000-0001-6946-7627
Alessandro SetteCenter for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA 92037, USA.
Alba GrifoniCenter for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA 92037, USA.
Mark M DavisDepartment of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA.ORCID 0000-0001-6868-657X
Calvin J KuoDepartment of Medicine, Divisions of Hematology, Stanford University School of Medicine, Stanford, CA 94305, USA.ORCID 0000-0002-7427-5985
Funding
MEDICAL SCIENTIST TRAINING PROGRAMT32GM007365 · NIGMS · STANFORD UNIVERSITY · PI CHUA, KATRIN F · 1985 to 2021
$33.8MStanford/UNC Biomimetic U19 Research CenterU19AI116484 · NIAID · STANFORD UNIVERSITY · PI GREENBERG, HARRY BERNARD · 2015 to 2025
$13.5MEMERGING INFECTIOUS DISEASEST32AI007502 · NIAID · STANFORD UNIVERSITY · PI Prasanna Jagannathan, DAVID A. RELMAN · 1995 to 2026
$6.8MEffects of aging on primary and secondary vaccine responses in a 15-year longitudinal cohortR01AI130398 · NIAID · STANFORD UNIVERSITY · PI BOYD, SCOTT DEXTER · 2017 to 2021
$4.0MStanford Training Program in Lung BiologyT32HL129970 · NHLBI · STANFORD UNIVERSITY · PI CORNFIELD, DAVID N., NICOLLS, MARK ROBERT · 2016 to 2025
$3.2MStorage and recall of human B cell memory of influenza over tissues and timeR01AI127877 · NIAID · STANFORD UNIVERSITY · PI BOYD, SCOTT DEXTER · 2017 to 2021
$2.0MIntestinal organoid modeling of SARS-CoV-2-stimulated innate and adaptive immunityR01DK130414 · NIDDK · STANFORD UNIVERSITY · PI KUO, CALVIN J · 2021 to 2023
$1.2MModeling early SARS-CoV-2 pathogenesis in human lung organoids and slice culturesK08AI163369 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI RUSTAGI, ARJUN · 2022 to 2025
$772kNHLBI NIH HHS T32 HL129970NIAID NIH HHS K08 AI163369NIAID NIH HHS R01 AI127877NIAID NIH HHS R01 AI130398NIAID NIH HHS T32 AI007502NIAID NIH HHS U19 AI116484NIDDK NIH HHS R01 DK130414NIGMS NIH HHS T32 GM007365
Abstract
Tissue-resident immunity mediates host defense against pathogens and enables rapid adaptive memory responses. However, the study of tissue-resident immunity is hindered by a singular lack of experimental systems allowing pathogenic epithelial infection amidst the full spectrum of endogenous immune subsets. Particularly in lung, differing notions of transient versus sustained residency of tissue-resident memory T cells (T
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.