Evidence map›Paper›PMID 37205372›Full record

ArticlebioRxiv : the preprint server for biology2023

TDP-43 pathology in

S Krupp, O Tam, M Gale Hammell, J Dubnau

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

S KruppProgram in Neuroscience, Department of Neurobiology and Behavior, Stony Brook University, NY 11794, USA.
O TamCold Spring Harbor Laboratory, 1 Bungtown road, Cold Spring Harbor, NY.,11794.
M Gale HammellCold Spring Harbor Laboratory, 1 Bungtown road, Cold Spring Harbor, NY.,11794.
J DubnauProgram in Neuroscience, Department of Neurobiology and Behavior, Stony Brook University, NY 11794, USA.
Cold Spring Harbor Laboratory · USStony Brook School · USStony Brook University · US

Funding

A systems approach to uncover upstream activators and common downstream pathways of neurodegeneration in a Drosophila modelRF1AG057338 · NIA · STATE UNIVERSITY NEW YORK STONY BROOK · PI DUBNAU, JOSHUA T · 2017 to 2019
$3.8M
Feedback amplification between Retrotransposons/endogenous retroviruses and TDP-43 in Alzheimers related dementiasR01AG078788 · NIA · STATE UNIVERSITY NEW YORK STONY BROOK · PI JOSHUA T DUBNAU · 2022 to 2026
$3.8M
Brain aging and Alzheimer's related dementias: convergence onto retrotransposons and endogenous retrovirusesRF1AG076493 · NIA · STATE UNIVERSITY NEW YORK STONY BROOK · PI DUBNAU, JOSHUA T · 2022 to 2022
$1.8M
NIA NIH HHS R01 AG078788NIA NIH HHS RF1 AG057338NIA NIH HHS RF1 AG076493
6 · The paper itself

Abstract

Accumulation of cytoplasmic inclusions of TAR-DNA binding protein 43 (TDP-43) is seen in both neurons and glia in a range of neurodegenerative disorders, including amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD) and Alzheimer's disease (AD). Disease progression involves non-cell autonomous interactions among multiple cell types, including neurons, microglia and astrocytes. We investigated the effects in

Identifiers

PMID37205372
PMCPMC10187300
OpenAlexW4372404312

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.