Evidence map›Paper›PMID 37205365›Full record

ArticlebioRxiv : the preprint server for biology2023

Hypoxia-inducible factor induces cysteine dioxygenase and promotes cysteine homeostasis in

Kurt Warnhoff, Sushila Bhattacharya, Jennifer Snoozy, Peter C Breen, Gary Ruvkun

Open access · greenAbstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Kurt WarnhoffPediatrics and Rare Diseases Group, Sanford Research, Sioux Falls, SD 57104, USA.ORCID 0000-0002-9503-0557
Sushila BhattacharyaPediatrics and Rare Diseases Group, Sanford Research, Sioux Falls, SD 57104, USA.
Jennifer SnoozyPediatrics and Rare Diseases Group, Sanford Research, Sioux Falls, SD 57104, USA.
Peter C BreenDepartment of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA.
Gary RuvkunDepartment of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA.
Massachusetts General Hospital · USSanford Research · USUniversity of South Dakota · US

Funding

CONTROL OF THE C ELEGANS LINEAGE BY HETEROCHRONIC GENESR01GM044619 · NIGMS · MASSACHUSETTS GENERAL HOSPITAL · PI GARY B RUVKUN · 1991 to 2026
$14.5M
Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Aric L Daul, Ann E. Rougvie · 2012 to 2026
$7.5M
Genetic analyses of molybdenum cofactor biologyR35GM146871 · NIGMS · SANFORD RESEARCH/USD · PI Kurt Warnhoff · 2022 to 2026
$2.1M
NIGMS NIH HHS R01 GM044619NIGMS NIH HHS R35 GM146871NIH HHS P40 OD010440
6 · The paper itself

Abstract

Dedicated genetic pathways regulate cysteine homeostasis. For example, high levels of cysteine activate cysteine dioxygenase, a key enzyme in cysteine catabolism in most animal and many fungal species. The mechanism by which cysteine dioxygenase is regulated is largely unknown. In an unbiased genetic screen for mutations that activate cysteine dioxygenase (

Identifiers

PMID37205365
PMCPMC10187278
OpenAlexW4375868253

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.