Evidence map›Paper›PMID 37204752›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2023

Protocol for the Investigation of Plasma and Whole Blood Clot Property of Fibrin Fiber Thickness Using Scanning Electron Microscopy.

Tengyi Cai, Conor McCafferty, Suelyn Van Den Helm, Natasha Letunica, Chantal Attard, Paul Monagle, Vera Ignjatovic

Abstract read
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In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
4.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Tengyi CaiMurdoch Children's Research Institute, Parkville, Australia.
Conor McCaffertyMurdoch Children's Research Institute, Parkville, Australia.
Suelyn Van Den HelmMurdoch Children's Research Institute, Parkville, Australia.
Natasha LetunicaMurdoch Children's Research Institute, Parkville, Australia.
Chantal AttardMurdoch Children's Research Institute, Parkville, Australia.
Paul MonagleMurdoch Children's Research Institute, Parkville, Australia.
Vera IgnjatovicMurdoch Children's Research Institute, Parkville, Australia. verai@unimelb.edu.au.
University of Melbourne · AUMurdoch Children's Research Institute · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Blood clot formation represents a key component of the coagulation process for preventing excessive hemorrhage. The structural characteristics of blood clots are associated with their strength and susceptibility to fibrinolysis. Scanning electron microscopy is a technique that allows for state-of-the-art image capture of blood clots, providing visualization of topography, fibrin thickness, fibrin network density, and blood cell involvement and morphology. In this chapter, we provide a detailed protocol for characterization of plasma and whole blood clot structure using SEM, covering the spectrum from blood collection, in vitro clot formation, sample preparation for SEM, imaging, and image analysis, specifically focusing on the measurement of fibrin fiber thickness.

Indexed as

FibrinThrombosisBlood CoagulationFibrinolysisHumansMicroscopy, Electron, ScanningFibrinClot generationFibrinPlasmaScanning electron microscopeWhole blood

Identifiers

PMID37204752
OpenAlexW4377092926

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.