Evidence map›Paper›PMID 37204696›Full record

ReviewInflammopharmacology2023

Omicron variant evolution on vaccines and monoclonal antibodies.

Michela Sabbatucci, Antonio Vitiello, Salvatore Clemente, Andrea Zovi, Mariarosaria Boccellino, Francesco Ferrara, Carla Cimmino, Roberto Langella, Annarita Ponzo, Paola Stefanelli and 1 more

Abstract readReview
In one paragraph

Review in Inflammopharmacology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

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  13. Trend analysis of proton pump inhibitor consumption and expenditure: The real-world evidence.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2024
    Article
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  17. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Michela SabbatucciMinistry of Health, Directorate-General for Health Prevention, Viale Giorgio Ribotta 5, 00144, Rome, Italy.ORCID http://orcid.org/0000-0001-5889-1780
Antonio VitielloMinistry of Health, Directorate-General for Health Prevention, Viale Giorgio Ribotta 5, 00144, Rome, Italy.ORCID http://orcid.org/0000-0003-2623-166X
Salvatore ClementeMinistry of Health, Directorate-General for Health Prevention, Viale Giorgio Ribotta 5, 00144, Rome, Italy.
Andrea ZoviMinistry of Health, Directorate General of Hygiene, Food Safety and Nutrition, Viale Giorgio Ribotta 5, 00144, Rome, Italy. zovi.andrea@gmail.com.ORCID http://orcid.org/0000-0002-6528-2171
Mariarosaria BoccellinoDepartment of Precision Medicine, University of Campania "Luigi Vanvitelli", Naples, Italy.
Francesco FerraraPharmaceutical Department, Local Health Unit Napoli 3 Sud, Dell'amicizia Street 22, 80035, Nola, Italy.
Carla CimminoDepartment of Precision Medicine, University of Campania "Luigi Vanvitelli", Naples, Italy.
Roberto LangellaDepartment of Pharmaceutics, Agency for Health Protection of the Metropolitan Area of Milan, Milan, Italy.
Annarita PonzoUniversity of Pavia, Pavia, Italy.
Paola StefanelliDepartment Infectious Diseases, Italian National Institute of Health, Viale Regina Elena 299, 00161, Rome, Italy.
Giovanni RezzaMinistry of Health, Directorate-General for Health Prevention, Viale Giorgio Ribotta 5, 00144, Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The severe acute respiratory syndrome coronavirus (SARS-CoV)-2 responsible for the global COVID-19 pandemic has caused almost 760 million confirmed cases and 7 million deaths worldwide, as of end-February 2023. Since the beginning of the first COVID-19 case, several virus variants have emerged: Alpha (B1.1.7), Beta (B135.1), Gamma (P.1), Delta (B.1.617.2) and then Omicron (B.1.1.529) and its sublineages. All variants have diversified in transmissibility, virulence, and pathogenicity. All the newly emerging SARS-CoV-2 variants appear to contain some similar mutations associated with greater "evasiveness" of the virus to immune defences. From early 2022 onward, several Omicron subvariants named BA.1, BA.2, BA.3, BA.4, and BA.5, with comparable mutation forms, have followed. After the wave of contagions caused by Omicron BA.5, a new Indian variant named Centaurus BA.2.75 and its new subvariant BA.2.75.2, a second-generation evolution of the Omicron variant BA.2, have recently been identified. From early evidence, it appears that this new variant has higher affinity for the cell entry receptor ACE-2, making it potentially able to spread very fast. According to the latest studies, the BA.2.75.2 variant may be able to evade more antibodies in the bloodstream generated by vaccination or previous infection, and it may be more resistant to antiviral and monoclonal antibody drug treatments. In this manuscript, the authors highlight and describe the latest evidences and critical issues have emerged on the new SARS-CoV-2 variants.

Indexed as

COVID-19VaccinesAntibodies, MonoclonalHumansPandemicsSARS-CoV-2Antibodies, MonoclonalVaccinesAntiviral drugsB.1.1.529CoronavirusCOVID-19EpidemiologyMonoclonal antibodiesMutationsOmicronPandemicPublic healthSARS-CoV-2Spike proteinVaccinesVariantsVOCVOI

Identifiers

PMID37204696
PMCPMC10198014

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.