Evidence map›Paper›PMID 37204489›Full record

ArticleLangenbeck's archives of surgery2023

Predictive factors associated with anastomotic leakage after resection of rectal cancer: a multicenter study with the Hiroshima Surgical study group of Clinical Oncology.

Tomoaki Bekki, Manabu Shimomura, Tomohiro Adachi, Masashi Miguchi, Satoshi Ikeda, Masanori Yoshimitsu, Mohei Kohyama, Masahiro Nakahara, Hironori Kobayashi, Kazuhiro Toyota and 10 more

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Langenbeck's archives of surgery, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Pooled it
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  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 10 institutions in 1 country.

Tomoaki BekkiDepartment of Gastroenterological and Transplant Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, Kasumi 1-2-3 Minami-Ku, Hiroshima, Hiroshima, Japan.ORCID http://orcid.org/0000-0003-0155-2360
Manabu ShimomuraDepartment of Gastroenterological and Transplant Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, Kasumi 1-2-3 Minami-Ku, Hiroshima, Hiroshima, Japan. mshimo@hiroshima-u.ac.jp.
Tomohiro AdachiDepartment of Surgery, Hiroshima City North Medical Center Asa Citizens Hospital, Hiroshima, Japan.
Masashi MiguchiDepartment of Gastroenterological Surgery, Hiroshima Prefectural Hospital, Hiroshima, Japan.
Satoshi IkedaDepartment of Gastroenterological Surgery, Hiroshima Prefectural Hospital, Hiroshima, Japan.
Masanori YoshimitsuDepartment of Surgery, Hiroshima City Hiroshima Citizens Hospital, Hiroshima, Japan.
Mohei KohyamaDepartment of Surgery, Hiroshima General Hospital, Hatsukaichi, Japan.
Masahiro NakaharaDepartment of Surgery, Onomichi General Hospital, Onomichi, Japan.
Hironori KobayashiDepartment of Surgery, Hiroshima Memorial Hospital, Hiroshima, Japan.
Kazuhiro ToyotaDepartment of Gastroenterological Surgery, National Hospital Organization Higashihiroshima Medical Center, Higashihiroshima, Japan.
Yosuke ShimizuDepartment of Surgery, National Hospital Organization Kure Medical Center/ Chugoku Cancer Center, Institute for Clinical Research, Kure, Japan.
Daisuke SumitaniDepartment of Surgery, JR Hiroshima Hospital, Hiroshima, Japan.
Yasufumi SaitoDepartment of Surgery, Chugoku Rosai Hospital, Kure, Japan.
Yuji TakakuraDepartment of Surgery, Chuden Hospital, Hiroshima, Japan.
Yasuyo IshizakiDepartment of Surgery, National Hospital Organization Hiroshima-Nishi Medical Center, Otake, Japan.
Shinya KodamaDepartment of Surgery, Yoshida General Hospital, Akitakata, Japan.
Masahiko FujimoriDepartment of Surgery, Kure City Medical Association Hospital, Kure, Japan.
Minoru HattoriAdvanced Medical Skills Training Center, Institute of Biomedical and Health Science, Hiroshima University, Hiroshima, Japan.
Wataru ShimizuDepartment of Gastroenterological and Transplant Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, Kasumi 1-2-3 Minami-Ku, Hiroshima, Hiroshima, Japan.
Hideki OhdanDepartment of Gastroenterological and Transplant Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, Kasumi 1-2-3 Minami-Ku, Hiroshima, Hiroshima, Japan.ORCID http://orcid.org/0000-0002-9066-1288
Hiroshima University · JPHiroshima City Asa Citizens Hospital · JPHiroshima General Hospital · JPHiroshima Prefectural Hospital · JPNational Hospital Organization · JPChugoku Rosai Hospital · JPHigashihiroshima Medical Center · JPKure Medical Center · JPNishida Hospital · JPOnomichi General Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeSeveral factors have been reported as risk factors for anastomotic leakage after resection of rectal cancer. This study aimed to evaluate the risk factors for anastomotic leakage, including nutritional and immunological indices, following rectal cancer resection.

methodsThis study used a multicenter database of 803 patients from the Hiroshima Surgical study group of Clinical Oncology who underwent rectal resection with stapled anastomosis for rectal cancer between October 2016 and April 2020.

resultsIn total, 64 patients (8.0%) developed postoperative anastomotic leakage. Five factors were significantly associated with the development of anastomotic leakage after rectal cancer resection with stapled anastomosis: male sex, diabetes mellitus, C-reactive protein/albumin ratio ≥ 0.07, prognostic nutritional index < 40, and low anastomosis under peritoneal reflection. The incidence of anastomotic leakage was correlated with the number of risk factors. The novel predictive formula based on odds ratios in the multivariate analysis was useful for identifying patients at high risk for anastomotic leakage. Diverting ileostomy reduced the ratio of anastomotic leakage ≥ grade III after rectal cancer resection.

conclusionsMale sex, diabetes mellitus, C-reactive protein/albumin ratio ≥ 0.07, prognostic nutritional index < 40, and low anastomosis under peritoneal reflection are possible risk factors for developing anastomotic leakage after rectal cancer resection with the stapled anastomosis. Patients at high risk of anastomotic leakage should be assessed for the potential benefits of diverting stoma.

Indexed as

Anastomotic LeakRectal NeoplasmsAnastomosis, SurgicalC-Reactive ProteinHumansMaleMedical OncologyRetrospective StudiesRisk FactorsC-Reactive ProteinAnastomotic leakageNutritional and immunological indicesRectal cancerRectal resection

Identifiers

PMID37204489
OpenAlexW4377094660

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.