Evidence map›Paper›PMID 37204422›Full record

ArticleMicrobial genomics2023

Genomic variation during culture adaptation of genetically complex

Antoine Claessens, Lindsay B Stewart, Eleanor Drury, Ambroise D Ahouidi, Alfred Amambua-Ngwa, Mahamadou Diakite, Dominic P Kwiatkowski, Gordon A Awandare, David J Conway

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microbial genomics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 6 countries.

Antoine ClaessensLPHI, MIVEGEC, INSERM, CNRS, IRD, University of Montpellier, France.
Lindsay B StewartDepartment of Infection Biology, London School of Hygiene and Tropical Medicine, Keppel St, London, WC1E 7HT, UK.
Eleanor DruryWellcome Sanger Institute, Cambridge, CB10 1SA, UK.
Ambroise D AhouidiLe Dantec Hospital, Université Cheikh Anta Diop, Dakar, Senegal.
Alfred Amambua-NgwaMRC Unit The Gambia at London School of Hygiene and Tropical Medicine, Banjul, The Gambia.
Mahamadou DiakiteMalaria Research and Training Center, University of Bamako, Bamako, Mali.
Dominic P KwiatkowskiWellcome Sanger Institute, Cambridge, CB10 1SA, UK.
Gordon A AwandareWest African Centre for Cell Biology of Infectious Pathogens, Department of Biochemistry, Cell and Molecular Biology, University of Ghana, Legon, Ghana.
David J ConwayDepartment of Infection Biology, London School of Hygiene and Tropical Medicine, Keppel St, London, WC1E 7HT, UK.
University of London · GBWellcome Sanger Institute · GBCheikh Anta Diop University · SNMRC Unit the Gambia · GMUniversity of Bamako · MLUniversity of Ghana · GH

Funding

Medical Research Council G1100123Medical Research Council MR/S009760/1Wellcome Trust 090770Wellcome Trust 098051Wellcome Trust 206194
6 · The paper itself

Abstract

Experimental studies on the biology of malaria parasites have mostly been based on laboratory-adapted lines, but there is limited understanding of how these may differ from parasites in natural infections. Loss-of-function mutants have previously been shown to emerge during culture of some

Indexed as

MalariaPlasmodium falciparumGenomicsGenotypeGuanine Nucleotide Exchange FactorsHumansProtein Serine-Threonine KinasesGuanine Nucleotide Exchange FactorsProtein Serine-Threonine KinasesSRPK1 protein, humanadaptationculturegenomic relatednessloss-of-function mutantsmixed genotypes

Identifiers

PMID37204422
PMCPMC10272863
OpenAlexW4377094226

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.