ArticleeLife2023
An acetylation-mediated chromatin switch governs H3K4 methylation read-write capability.
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Article in eLife, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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45citing papers in PubMed
7.8field-weighted citation impact, top 2% of its field
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Who cites it
45 citing papers in PubMed, 52 citations in OpenAlex.
- Research progress on lysine acetylation (Review).International journal of molecular medicine · 2026Review
- Narrative Review of Nanomaterial Interactions in Plants with a Focus on Multi-Omics and Epigenetic Remodeling.Plants (Basel, Switzerland) · 2026Review
- Nonlinearities and Switch-Like Behavior in Gene Expression: From Genetics to Biochemistry and Back.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Review
- Cigarette smoke induces FASN-dependent fatty acid metabolic rewiring to drive bladder cancer progression.Cancer letters · 2026Article
- Molecular mechanisms of the MLL4 complex in H3K4 methylation and p53-dependent transcription activation.Molecular cell · 2026Article
- H2AX C-Terminal Dipeptide Truncation: A Master Switch of the DNA Damage Response.bioRxiv : the preprint server for biology · 2026Article
- Histone modification cross-talk: analytical tools and molecular mechanisms.The Biochemical journal · 2026Review
- KAT6A is essential for developmental control gene expression in neural stem and progenitor cells.PLoS genetics · 2026Article
- Tandem bromodomains of BRD4 cooperatively read poly-acetylated nucleosomes to enhance chromatin engagement and regulate breast cancer phenotypes.bioRxiv : the preprint server for biology · 2026Article
- Proteoform medicine: characterizing and targeting protein forms in human disease.Nature reviews. Genetics · 2026Review
- Unraveling the complexity of the histone code: implications for gene regulation and disease.Genome biology · 2026Review
- Direct Readout of Multivalent Chromatin Reader-Nucleosome Interactions by Nucleosome Mass Spectrometry.ACS central science · 2026Article
- The role of HMGA1 in genome stability: Implications in human cancer.Cellular and molecular life sciences : CMLS · 2026Review
- G34R cancer mutation alters the conformational ensemble and dynamics of the histone H3.3 tails.Nucleic acids research · 2026Article
- Review
- Nucleosome context regulates chromatin reader preference.Nucleic acids research · 2025Article
- A needed nomenclature for nucleosomes.Molecular cell · 2025Review
- SETD2 suppresses tumorigenesis in a KRASeLife · 2025Article
- Article
- SOX2 drives esophageal squamous carcinoma by reprogramming lipid metabolism and histone acetylation landscape.Nature communications · 2025Article
Corrections and comments
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Authors and funding
30 authors at 5 institutions in 1 country.
Kanishk JainDepartment of Biochemistry and Biophysics, University of North Carolina at Chapel Hill of Medicine, Chapel Hill, United States.ORCID 0000-0001-8039-0464
Matthew R MarundeEpiCypher, Inc, Durham, United States.
Jonathan M BurgEpiCypher, Inc, Durham, United States.
Susan L GloorEpiCypher, Inc, Durham, United States.
Faith M JosephVerna & Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, United States.
Karl F PonchaVerna & Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, United States.
Zachary B GillespieEpiCypher, Inc, Durham, United States.
Keli L RodriguezEpiCypher, Inc, Durham, United States.
Irina K PopovaEpiCypher, Inc, Durham, United States.
Nathan W HallEpiCypher, Inc, Durham, United States.
Anup VaidyaEpiCypher, Inc, Durham, United States.
Sarah A HowardEpiCypher, Inc, Durham, United States.
Hailey F TaylorEpiCypher, Inc, Durham, United States.
Laylo MukhsinovaEpiCypher, Inc, Durham, United States.
Ugochi C OnuohaEpiCypher, Inc, Durham, United States.
Emily F PattesonEpiCypher, Inc, Durham, United States.
Spencer W CookeDepartment of Biochemistry and Biophysics, University of North Carolina at Chapel Hill of Medicine, Chapel Hill, United States.
Bethany C TaylorVerna & Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, United States.
Ellen N WeinzapfelEpiCypher, Inc, Durham, United States.
Marcus A CheekEpiCypher, Inc, Durham, United States.
Matthew J MeinersEpiCypher, Inc, Durham, United States.
Geoffrey C FoxCurriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, School of Medicine, Chapel Hill, United States.ORCID 0000-0001-5898-0847
Kevin E W NamitzPennsylvania State University, State College, United States.ORCID 0000-0003-4434-1475
Martis W CowlesEpiCypher, Inc, Durham, United States.
Krzysztof KrajewskiDepartment of Biochemistry and Biophysics, University of North Carolina at Chapel Hill of Medicine, Chapel Hill, United States.
Zu-Wen SunEpiCypher, Inc, Durham, United States.
Michael S CosgroveDepartment of Biochemistry and Molecular Biology, Upstate Medical University, Syracuse, United States.
Nicolas L YoungVerna & Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, United States.ORCID 0000-0002-3323-2815
Michael-Christopher KeoghEpiCypher, Inc, Durham, United States.ORCID 0000-0002-2219-8623
Brian D StrahlDepartment of Biochemistry and Biophysics, University of North Carolina at Chapel Hill of Medicine, Chapel Hill, United States.ORCID 0000-0002-4947-6259
EpiCypher (United States) · USUniversity of North Carolina at Chapel Hill · USBaylor College of Medicine · USPennsylvania State University · USSUNY Upstate Medical University · US
Funding
Virology Research Program (Program 4)P30CA016086 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Deborah F. Tate · 1985 to 2026
$201.5MTMEM106b as a lysosomal adaptor to influence brain aging and tau pathogenesisP01AG066606 · NIA · BAYLOR COLLEGE OF MEDICINE · PI ZHENG, HUI · 2021 to 2025
$13.5MInitiative for Maximizing Student Development (IMSD) ProgramR25GM056929 · NIGMS · BAYLOR COLLEGE OF MEDICINE · PI PEREIRA, FRED A · 1998 to 2023
$12.4MYEARS 19 - 23: BCM POST-BACCALAUREATE RESEARCH EDUCATION PROGRAMR25GM069234 · NIGMS · BAYLOR COLLEGE OF MEDICINE · PI PEREIRA, FRED A · 2003 to 2024
$7.5MMechanisms of chromatin and transcriptional regulationR35GM126900 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Brian D Strahl · 2018 to 2026
$5.5MMETABOLIC REGULATION IN LEUKEMIA-INITIATING CELLSR01CA193235 · NCI · BAYLOR COLLEGE OF MEDICINE · PI NAKADA, DAISUKE · 2015 to 2024
$4.6MMolecular Mechanisms for the Assembly and Regulation of the MLL1 Core ComplexR01CA140522 · NCI · UPSTATE MEDICAL UNIVERSITY · PI COSGROVE, MICHAEL S. · 2010 to 2019
$3.6MNeutron encoded activity based probesR01GM139295 · NIGMS · BAYLOR COLLEGE OF MEDICINE · PI YOUNG, DAMIAN WINSTON, YOUNG, NICOLAS L · 2020 to 2024
$2.2MA novel protein engineering tool for rapid manufacturing of designer nucleosomesR44CA214076 · NCI · EPICYPHER, INC. · PI KEOGH, MICHAEL-CHRISTOPHER · 2018 to 2019
$2.0MCancer Epigenetics Training GrantT32CA217824 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI WEISSMAN, BERNARD E. · 2017 to 2021
$1.8MHigh-throughput methyltransferase assays using recombinant nucleosome substratesR44GM117683 · NIGMS · EPICYPHER, INC. · PI SUN, ZU-WEN · 2018 to 2019
$1.7MBarcoded nucleosomes for analyzing combinatorial epigenetic regulatorsR44GM116584 · NIGMS · EPICYPHER, INC. · PI SUN, ZU-WEN · 2017 to 2018
$1.6MNCI NIH HHS P30 CA016086NCI NIH HHS R01 CA140522NCI NIH HHS R01 CA193235NCI NIH HHS R43 CA236474NCI NIH HHS R44 CA214076NCI NIH HHS T32 CA217824NIA NIH HHS P01 AG066606NIGMS NIH HHS R01 GM139295NIGMS NIH HHS R25 GM056929NIGMS NIH HHS R25 GM069234NIGMS NIH HHS R35 GM126900NIGMS NIH HHS R44 GM116584NIGMS NIH HHS R44 GM117683
Abstract
In nucleosomes, histone N-terminal tails exist in dynamic equilibrium between free/accessible and collapsed/DNA-bound states. The latter state is expected to impact histone N-termini availability to the epigenetic machinery. Notably, H3 tail acetylation (e.g. K9ac, K14ac, K18ac) is linked to increased H3K4me3 engagement by the BPTF PHD finger, but it is unknown if this mechanism has a broader extension. Here, we show that H3 tail acetylation promotes nucleosomal accessibility to other H3K4 methyl readers, and importantly, extends to H3K4 writers, notably methyltransferase MLL1. This regulation is not observed on peptide substrates yet occurs on the
Indexed as
ChromatinHistonesAcetylationMethylationNucleosomesChromatinHistonesNucleosomesbiochemistrychemical biologychromatinchromosomesgene expressionH3K4 methylationhistone tail acetylationhumannucleosomesreaderswriters
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