ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2023
Latin American Initiative for Lifestyle Intervention to Prevent Cognitive Decline (LatAm-FINGERS): Study design and harmonization.
Registry-linked trialOpen access · greenAbstract readClinical Trial Protocol
In one paragraph
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06492967 (Latin American Lifestyle Intervention Initiative to Reduce the Risk and Prevent Cognitive Impairment.), which is not on this map. Cited by 43 papers, 4 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed, 4 pooled it
19.2field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Latin American Lifestyle Intervention Initiative to Reduce the Risk and Prevent Cognitive Impairment.
Who cites it
43 citing papers in PubMed, 4 syntheses or guidelines pooled it, 44 citations in OpenAlex.
- Reproductive life stages and cognitive outcomes: a systematic review in Latin American and Caribbean women.Frontiers in aging neuroscience · 2026Pooled it
- Risk reduction and precision prevention across the Alzheimer's disease continuum: a systematic review of clinical trials combining multidomain lifestyle interventions and pharmacological or nutraceutical approaches.The journal of prevention of Alzheimer's disease · 2025Pooled it
- The Mediterranean-Dietary Approaches to Stop Hypertension Intervention for Neurodegenerative Delay (MIND) Diet for the Aging Brain: A Systematic Review.Advances in nutrition (Bethesda, Md.) · 2024Pooled it
- Multidomain intervention for dementia prevention: a scoping review.Frontiers in neurologyPooled it
- Supera cognitive stimulation study with cognitively-unimpaired older adults: methodology and initial results of a randomized controlled clinical trial.Arquivos de neuro-psiquiatria · 2025Trial
- Baseline cognition and demographic, lifestyle, and cardiovascular risk factors in US POINTER.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Trial
- Baseline characteristics of the U.S. Study to Protect Brain Health Through Lifestyle Intervention to Reduce Risk (U.S. POINTER): Successful enrollment of a diverse clinical trial cohort at risk for cognitive decline.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Trial
- Association of micronutrient levels with dementia risk in adults in Telangana, India: a cross-sectional study (2023-2024).The Lancet regional health. Southeast Asia · 2026Article
- The past, present, and future of Alzheimer's disease-part 3: the future.Arquivos de neuro-psiquiatria · 2026Review
- Contextualizing Blood-Based Biomarkers for Dementia Globally.Journal of neurochemistry · 2026Review
- A harmonized framework for studying exceptional cognitive aging in Latin America.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Resource-stratified machine learning framework for cognitive status classification and mild cognitive impairment to dementia progression prediction.Alzheimer's research & therapy · 2026Article
- The landscape of dementia research, diagnosis, treatment, and care in Latin America.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Review
- Scientific knowledge about dementia: From the Global South to the world.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Review
- A multilevel conceptual framework for dementia: from life-course mechanisms to public health strategies.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas · 2026Review
- Building brain resilience through brain capital.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Navigating dementia care: a qualitative study of family care partners' experiences in managing behavioural and psychological symptoms in Lima, Peru.Frontiers in dementia · 2026Article
- Capacity building in dementia research: insights from the World Young Leaders in Dementia.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- An mHealth App (NeoMayor) to Promote Healthy Lifestyles and Brain Health in Older Adults: Design and Validation Study.JMIR aging · 2025Article
- Broadening dementia risk models: building on the 2024 Lancet Commission report for a more inclusive global framework.EBioMedicine · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
59 authors at 20 institutions in 15 countries.
Lucia CrivelliDepartment of Cognitive Neurology, Fleni, Buenos Aires, Argentina.
Ismael Luis CalandriDepartment of Cognitive Neurology, Fleni, Buenos Aires, Argentina.
Claudia Kimie SuemotoDivision of Geriatrics, University of São Paulo Medical School, São Paulo, Brazil.
Rosa María SalinasLaboratorio de Demencias del Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, Ciudad de México, México.
Lina Marcela VelillaNeuroscience Group of Antioquia Medical School, Antioquia University, Medellín, Colombia.
Mônica Sanches YassudaCognitive and Behavioral Neurology Unit, Department of Neurology, University of São Paulo School of Medicine, São Paulo, Brazil.
Paulo CaramelliBehavioral and Cognitive Neurology Unit, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Francisco LoperaNeuroscience Group of Antioquia Medical School, Antioquia University, Medellín, Colombia.
Ricardo NitriniCognitive and Behavioral Neurology Unit, Department of Neurology, University of São Paulo School of Medicine, São Paulo, Brazil.
Gustavo Emilio SevleverDepartment of Cognitive Neurology, Fleni, Buenos Aires, Argentina.
Ana Luisa SosaLaboratorio de Demencias del Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, Ciudad de México, México.
Daisy AcostaInternal Medicine Department, Universidad Nacional Pedro Henriquez Urena (UNPHU), Santo Domingo, Dominican Republic.
Ana María Charamelo BaiettiClínica de la Memoria-Hospital Británico, Montevideo, Uruguay.
María Isabel CusicanquiCentro Neurológico Mente Activa, La Paz, Bolivia.
Nilton CustodioUnidad de Diagnóstico de Deterioro Cognitivo y Prevención de Demencia, Instituto Peruano de Neurociencias, Lima, Perú.
Sergio Dansilio De SimoneDepartamento de Neuropsicología, Facultad de Medicina-Hospital de Clínicas, Universidad de la República, Montevideo, Uruguay.
Carolina Delgado DerioUnidad de Cerebro Saludable, Departamento de Neurología y Neurocirugía, Hospital Clínico Universidad de Chile, Santiago de Chile, Chile.
Lissette Duque-PeñaililloCognitive Disorders Unit-Neuromedicenter, Quito, Ecuador.
Juan Carlos DuranCentro Neurológico Mente Activa, La Paz, Bolivia.
Ivonne Z Jiménez-VelázquezCentro de Investigación en Geriatría, Departamento de Medicina Interna, Recinto de Ciencias Médicas, Universidad de Puerto Rico, San Juan, Puerto Rico.
Jorge Mario Leon-SalasDepartamento de Investigación Clínica, Life Science Research Institute, Hospital Clínica Bíblica, San José, Costa Rica.
Yanina BergamoDepartment of Diagnostic Imaging, Fleni, Buenos Aires, Argentina.
María Florencia ClarensDepartment of Cognitive Neurology, Fleni, Buenos Aires, Argentina.
Andrés DamianCUDIM Centro Uruguayo de Imagenología Molecular, Montevideo, Uruguay.
Ignacio DemeyDepartment of Cognitive Neurology, Fleni, Buenos Aires, Argentina.
María Belén HelouDepartment of Cognitive Neurology, Fleni, Buenos Aires, Argentina.
Carlos MárquezInstituto de Nutrición y Tecnología de los Alimentos, Universidad de Chile, Santiago de Chile, Chile.
María Eugenia MartinDepartment of Cognitive Neurology, Fleni, Buenos Aires, Argentina.
Maria da Graça Morais MartinDepartment of Radiology HCFMUSP, University of São Paulo School of Medicine, São Paulo, Brazil.
Diego QuerzeDepartment of Neurology, Fleni, Buenos Aires, Argentina.
Ezequiel Ignacio SuraceDepartment of Molecular Biology and Bioinformatics, Fleni, Buenos Aires, Argentina.
Sabrina Acosta-EgeaDepartamento de Investigación Clínica, Life Science Research Institute, Hospital Clínica Bíblica, San José, Costa Rica.
Esteban Aguirre-SalvadorCognitive Disorders Unit-Neuromedicenter, Quito, Ecuador.
Leonardo Cruz de SouzaBehavioral and Cognitive Neurology Unit, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Gustavo Henrique da Cunha Peixoto CançadoEscola de Educação Física, Fisioterapia e Terapia Ocupacional, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Sonia Maria Dozzi BruckiCognitive and Behavioral Neurology Unit, Department of Neurology, University of São Paulo School of Medicine, São Paulo, Brazil.
Clarisse Vasconcelos FriedlaenderBehavioral and Cognitive Neurology Unit, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Karina Braga GomesFaculdade de Farmácia, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Myriam GutierrezUnidad de Cerebro Saludable, Departamento de Neurociencia, Facultad de Medicina, Universidad de Chile, Santiago de Chile, Chile.
Carlos Laforcada RíosCentro Neurológico Mente Activa, La Paz, Bolivia.
Joyce Graciela Martinez GalindoLaboratorio de Demencias del Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, Ciudad de México, México.
Rosa MontesinosUnidad de Diagnóstico de Deterioro Cognitivo y Prevención de Demencia, Instituto Peruano de Neurociencias, Lima, Perú.
Alberto Nuñez-HerreraCognitive Disorders Unit-Neuromedicenter, Quito, Ecuador.
Sebastián Ospina-HenaoFacultad de Medicina, Universidad de Ciencias Médicas, Instituto de Investigación en Ciencias Médicas, San José, Costa Rica.
Guillermina RodríguezDepartment of Demography and Biostatistics, Ministry of Public Health, Santo Domingo, Dominican Republic.
Victoria Ruiz MassonCognitive Disorders Unit-Neuromedicenter, Quito, Ecuador.
Mónica SánchezCognitive Disorders Unit-Neuromedicenter, Quito, Ecuador.
Christian E SchenkNeurology Division, Medical Sciences Campus, University of Puerto Rico, San Juan, Puerto Rico.
Ligia SotoCognitive Disorders Unit-Neuromedicenter, Quito, Ecuador.
Maira Tonidandel BarbosaBehavioral and Cognitive Neurology Unit, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Jéssica Abdo Gonçalves TosattiBehavioral and Cognitive Neurology Unit, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Yosselin VicuñaInbiomed (Instituto de Investigación en Biomedicina), Universidad Central del Ecuador, Quito, Ecuador.
Mark EspelandDepartments of Internal Medicine and Biostatistics and Data Science, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
Krister HakanssonDivision of Clinical Geriatrics, Karolinska Institutet, Stockholm, Sweden.
Miia KivipeltoDivision of Clinical Geriatrics, Centre for Alzheimer Research, Karolinska Institutet and Theme Inflammation and Aging, Karolinska University Hospital, Stockholm, Sweden.
Laura BakerDepartments of Internal Medicine, Neurology, and Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
Heather SnyderAlzheimer's Association, Chicago, Illinois, USA.
María CarrilloAlzheimer's Association, Chicago, Illinois, USA.
Ricardo Francisco AllegriDepartment of Cognitive Neurology, Fleni, Buenos Aires, Argentina.
Instituto de Neurología Cognitiva · ARUniversidade Federal de Minas Gerais · BRUniversidade de São Paulo · BRFundación para la Lucha contra las Enfermedades Neurológicas de la Infancia · ARInstituto Nacional de Neurología y Neurocirugía · MXAlzheimer's Association · USUniversidad Bíblica Latinoamericana · CRUniversidad de Antioquia · COUniversidad de la República · UYUniversity of Puerto Rico, Medical Sciences Campus · PRWake Forest University · USCentral University of Ecuador · ECCentro Uruguayo de Imagenología Molecular · UYHospital Clínico de la Universidad de Chile · CLInstituto Tecnológico de Santo Domingo · DOKarolinska Institutet · SEKarolinska University Hospital · SEUniversidad de Ciencias Medicas · CRUniversidad de Santiago de Chile · CLUniversidad Nacional Pedro Henríquez Ureña · DO
Funding
South Texas Alzheimer's Disease Research CenterP30AG066546 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Sudha Seshadri · 2021 to 2026
$24.0MBrain Aging, AD and Dementia in Low and Middle Income Countries (LMICs) and Low Resource Settings: Gender, Genetics, Risk Factors, Pathophysiology and PreventionR13AG066391 · NIA · UNIVERSITY OF TEXAS RIO GRANDE VALLEY · PI CARRILLO, MARIA C, KALARIA, RAJ N · 2020 to 2020
$50kNIA NIH HHS P30 AG066546NIA NIH HHS R13 AG066391
Abstract
introductionLatin American Initiative for Lifestyle Intervention to Prevent Cognitive Decline (LatAm-FINGERS) is the first non-pharmacological multicenter randomized clinical trial (RCT) to prevent cognitive impairment in Latin America (LA). Our aim is to present the study design and discuss the strategies used for multicultural harmonization.
methodsThis 1-year RCT (working on a 1-year extension) investigates the feasibility of a multi-domain lifestyle intervention in LA and the efficacy of the intervention, primarily on cognitive function. An external harmonization process was carried out to follow the FINGER model, and an internal harmonization was performed to ensure this study was feasible and comparable across the 12 participating LA countries.
resultsCurrently, 1549 participants have been screened, and 815 randomized. Participants are ethnically diverse (56% are Nestizo) and have high cardiovascular risk (39% have metabolic syndrome). DISCUSSION: LatAm-FINGERS overcame a significant challenge to combine the region's diversity into a multi-domain risk reduction intervention feasible across LA while preserving the original FINGER design.
Indexed as
Cognitive DysfunctionCognitionHumansLatin AmericaLife StyleMulticenter Studies as TopicRandomized Controlled Trials as TopicResearch DesignAlzheimer's diseasecognitive impairmentdementia lifestylemultidomain interventionpreventionrandomized controlled trialWorld-Wide FINGERS
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
NCT06492967ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.