Evidence map›Paper›PMID 37203444›Full record

ArticlePsychological medicine2024

Examining associations between genetic and neural risk for externalizing behaviors in adolescence and early adulthood.

Sarah J Brislin, Jessica E Salvatore, Jacquelyn M Meyers, Chella Kamarajan, Martin H Plawecki, Howard J Edenberg, Samuel Kuperman, Jay Tischfield, Victor Hesselbrock, Andrey P Anokhin and 11 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Psychological medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 7 institutions in 1 country.

Sarah J BrislinDepartment of Psychiatry, Robert Wood Johnson Medical School, Rutgers University, New Brunswick-Piscataway, NJ, USA.ORCID https://orcid.org/0000-0003-4303-8124
Jessica E SalvatoreDepartment of Psychiatry, Robert Wood Johnson Medical School, Rutgers University, New Brunswick-Piscataway, NJ, USA.
Jacquelyn M MeyersDepartment of Psychiatry and Behavioral Sciences, State University of New York Downstate Medical Center, New York, NY, USA.
Chella KamarajanDepartment of Psychiatry and Behavioral Sciences, State University of New York Downstate Medical Center, New York, NY, USA.
Martin H PlaweckiDepartment of Psychiatry, Indiana University, Bloomington, IN, USA.
Howard J EdenbergDepartment of Biochemistry and Molecular Biology, Indiana University, Bloomington, IN, USA.
Samuel KupermanDepartment of Psychiatry, University of Iowa, Iowa City, IA, USA.
Jay TischfieldDepartment of Psychiatry, Robert Wood Johnson Medical School, Rutgers University, New Brunswick-Piscataway, NJ, USA.
Victor HesselbrockDepartment of Psychiatry, University of Connecticut School of Medicine, Farmington, CT, USA.
Andrey P AnokhinDepartment of Psychiatry, Washington University in St. Louis, St. Louis, MO, USA.
David B ChorlianDepartment of Psychiatry and Behavioral Sciences, State University of New York Downstate Medical Center, New York, NY, USA.
Marc A SchuckitDepartment of Psychiatry, University of California San Diego Medical School, San Diego, CA, USA.
John I NurnbergerDepartment of Psychiatry, Indiana University, Bloomington, IN, USA.
Lance BauerDepartment of Psychiatry, University of Connecticut School of Medicine, Farmington, CT, USA.
Gayathri PandeyDepartment of Psychiatry and Behavioral Sciences, State University of New York Downstate Medical Center, New York, NY, USA.
Ashwini K PandeyDepartment of Psychiatry and Behavioral Sciences, State University of New York Downstate Medical Center, New York, NY, USA.
John R KramerDepartment of Psychiatry, University of Iowa, Iowa City, IA, USA.
Grace ChanDepartment of Psychiatry, University of Iowa, Iowa City, IA, USA.ORCID https://orcid.org/0000-0002-1257-6889
Bernice PorjeszDepartment of Psychiatry and Behavioral Sciences, State University of New York Downstate Medical Center, New York, NY, USA.
COGA Collaborators
Danielle M DickDepartment of Psychiatry, Robert Wood Johnson Medical School, Rutgers University, New Brunswick-Piscataway, NJ, USA.
State University of New York · USRutgers, The State University of New Jersey · USIndiana University Bloomington · USUniversity of Iowa · USUniversity of Connecticut · USUniversity of California San Diego Medical Center · USWashington University in St. Louis · US

Funding

Subject CollectionU10AA008401 · NIAAA · SUNY DOWNSTATE MEDICAL CENTER · PI JAY Arnold TISCHFIELD · 1989 to 2026
$162.7M
Using the Genetic Architecture of Substance Use Disorders to Advance Gene Identification and Understanding of Pathways of RiskR01DA050721 · NIDA · VIRGINIA COMMONWEALTH UNIVERSITY · PI DANIELLE M DICK · 2020 to 2026
$3.9M
NIAAA NIH HHS U10 AA008401NIDA NIH HHS R01 DA050721NIDA NIH HHS R01DA050721
6 · The paper itself

Abstract

backgroundResearchers have identified genetic and neural risk factors for externalizing behaviors. However, it has not yet been determined if genetic liability is conferred in part through associations with more proximal neurophysiological risk markers.

methodsParticipants from the Collaborative Study on the Genetics of Alcoholism, a large, family-based study of alcohol use disorders were genotyped and polygenic scores for externalizing (EXT PGS) were calculated. Associations with target P3 amplitude from a visual oddball task (P3) and broad endorsement of externalizing behaviors (indexed via self-report of alcohol and cannabis use, and antisocial behavior) were assessed in participants of European (EA;

resultsThe EXT PGS was significantly associated with higher levels of externalizing behaviors among EA adolescents and young adults as well as AA young adults. P3 was inversely associated with externalizing behaviors among EA young adults. EXT PGS was not significantly associated with P3 amplitude and therefore, there was no evidence that P3 amplitude indirectly accounted for the association between EXT PGS and externalizing behaviors.

conclusionsBoth the EXT PGS and P3 amplitude were significantly associated with externalizing behaviors among EA young adults. However, these associations with externalizing behaviors appear to be independent of each other, suggesting that they may index different facets of externalizing.

Indexed as

AlcoholismAdolescentAdultAntisocial Personality DisorderChildHumansRisk FactorsYoung AdultExternalizingneurophysiologyP3 amplitudepolygenic score

Identifiers

PMID37203444
PMCPMC11010461
OpenAlexW4377094571

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.