ArticleJournal of cachexia, sarcopenia and muscle2023
Psoas muscle index is not representative of skeletal muscle index for evaluating cancer sarcopenia.
Article in Journal of cachexia, sarcopenia and muscle, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 3 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 3 syntheses or guidelines pooled it, 28 citations in OpenAlex.
- Exploring the association between computed tomography (CT)-derived skeletal muscle mass and short- and long-term mortality in critically ill patients: a systematic review and meta-analysis.Critical care (London, England) · 2025Pooled it
- Impact of imaging-diagnosed sarcopenia on outcomes in patients with biliary tract cancer after surgical resection: a systematic review and meta-analysis.World journal of surgical oncology · 2024Pooled it
- Ct-based diagnosis of sarcopenia as a prognostic factor for postoperative mortality after elective open-heart surgery in older patients: a cohort-based systematic review and meta-analysis.Frontiers in public health · 2024Pooled it
- Goal-directed nutritional support in preserving muscle mass and optimising recovery in treatment of oesophageal cancer: results of a prospective non-randomised cluster trial.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Trial
- Postoperative muscle mass depletion in older patients undergoing major elective surgery.Journal of anesthesia, analgesia and critical care · 2026Article
- Preoperative Posterior Paraspinal Fatty Infiltration and an Exploratory Axial Muscle Imaging Phenotype in Surgically Treated Metastatic Epidural Spinal Cord Compression: A Retrospective Cohort Study.Medicina (Kaunas, Lithuania) · 2026Article
- Clinical impact of CT-defined sarcopenia on long-term oncological outcomes in gastric cancer: validation of muscle mass cut-offs established according to EWGSOP recommendations.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2026Article
- Cloud-Enabled Automated CT Assessment of Pelvic Muscle Quality in Women With and Without Low-Energy Femoral Neck Fracture.Calcified tissue international · 2026Article
- Development of a multivariable prediction model for tumor response and treatment tolerance based on body composition dynamics in rectal cancer undergoing neoadjuvant chemoradiotherapy.Journal of gastrointestinal oncology · 2026Article
- Prognostic Impact of Ectopic Fat Deposition Within the Psoas Muscle in Patients with Stage IV Pancreatic Cancer Receiving Systemic Chemotherapy.Journal of clinical medicine · 2026Article
- Methodological standards for body composition assessment-an expert-endorsed guide for research and clinical applications: bioimpedance, dual-energy X-ray absorptiometry, computerized tomography, and ultrasound methods.The American journal of clinical nutrition · 2026Review
- Skeletal muscle index and hand grip strength as predictors of postoperative recovery in patients with gastrointestinal tumors.BMC gastroenterology · 2026Observational
- Cellular and molecular mechanisms of fatty infiltration in paraspinal muscles in spine-specific sarcopenia.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2026Review
- Impact of Sarcopenia and Serum Creatinine on Clinical Outcomes after Tace in Hepatocellular Carcinoma.Journal of Cancer · 2026Article
- Research Progress of Sarcopenia Index in Chronic Obstructive Pulmonary Disease: A Review.Cureus · 2025Review
- Defining Low Muscle Mass in Cancer Patients: Sex-Specific Computed Tomography-Derived Cutoff Values and Survival Impact-A Multicenter Cohort Study.Annals of surgical oncology · 2025Article
- Review
- Computed tomography-based body composition and systemic inflammation for outcome prediction in patients with resectable esophageal squamous cell carcinoma.Journal of thoracic disease · 2025Article
- Validation of body composition parameters extracted via deep learning-based segmentation from routine computed tomographies.Scientific reports · 2025Article
- Review
Corrections and comments
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Authors and funding
11 authors at 10 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundA common method for diagnosing sarcopenia involves estimating the muscle mass by computed tomography (CT) via measurements of the cross-sectional muscle area (CSMA) of all muscles at the third lumbar vertebra (L3) level. Recently, single-muscle measurements of the psoas major muscle at L3 have emerged as a surrogate for sarcopenia detection, but its reliability and accuracy remain to be demonstrated.
methodsThis prospective cross-sectional study involved 29 healthcare establishments and recruited patients with metastatic cancers. The correlation between skeletal muscle index (SMI = CSMA of all muscles at L3/height
resultsSeven hundred and sixty-six patients were analysed (mean age 65.0 ± 11.8 years, 50.1% female). Low SMI prevalence was 69.1%. Correlation between the SMI and PMI for the entire population was 0.69 (n = 731, P < 0.01). PMI cut-offs for sarcopenia were estimated in the development population at <6.6cm
conclusionsA diagnostic test employing single-muscle measurements of the psoas major muscle as a surrogate for sarcopenia detection was evaluated but found to be unreliable. The CSMA of all muscles must be considered for evaluating cancer sarcopenia at L3.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.