Evidence map›Paper›PMID 37202563›Full record

ArticleParasitology research2023

Unusual metal ion cofactor requirement of Entamoeba histolytica choline and ethanolamine kinase isoforms.

Chiat Han Chang, Ling Ling Few, Boon Huat Lim, Get Bee Yvonne-Tee, Ai Lan Chew, Wei Cun See Too

Abstract read
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In one paragraph

Article in Parasitology research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Chiat Han ChangSchool of Health Sciences, Health Campus, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia.
Ling Ling FewSchool of Health Sciences, Health Campus, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia.ORCID http://orcid.org/0000-0001-8296-8135
Boon Huat LimSchool of Health Sciences, Health Campus, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia.
Get Bee Yvonne-TeeSchool of Health Sciences, Health Campus, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia.ORCID http://orcid.org/0000-0002-4254-7157
Ai Lan ChewInstitute for Research in Molecular Medicine (INFORMM), Universiti Sains Malaysia, 11800 USM, Penang, Malaysia.ORCID http://orcid.org/0000-0002-5497-6848
Wei Cun See TooSchool of Health Sciences, Health Campus, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia. stweicun@usm.my.ORCID http://orcid.org/0000-0003-1933-3107
Universiti Sains Malaysia · MY

Funding

Malaysia Ministry of Higher Education Fundamental Research Grant Scheme (FRGS) FRGS/1/2021/SKK0/USM/02/34
6 · The paper itself

Abstract

The de novo biosynthesis of phosphatidylcholine and phosphatidylethanolamine in Entamoeba histolytica is largely dependent on the CDP-choline and CDP-ethanolamine pathways. Although the first enzymes of these pathways, EhCK1 and EhCK2, have been previously characterized, their enzymatic activity was found to be low and undetectable, respectively. This study aimed to identify the unusual characteristics of these enzymes in this deadly parasite. The discovery that EhCKs prefer Mn

Indexed as

AmebiasisEntamoeba histolyticaAdenosine TriphosphateCholineCholine KinaseCytidine DiphosphateCytidine Diphosphate CholineEthanolamineEthanolaminesHumansKineticsPhosphatidylcholinesPhosphatidylethanolaminesPhosphotransferases (Alcohol Group Acceptor)Protein IsoformsAdenosine TriphosphateCDP ethanolamineCholineCholine KinaseCytidine DiphosphateCytidine Diphosphate CholineEthanolamineethanolamine kinaseEthanolaminesPhosphatidylcholinesPhosphatidylethanolaminesPhosphotransferases (Alcohol Group Acceptor)Protein IsoformsCholine kinaseEntamoeba histolyticaEthanolamine kinaseKennedy pathwayManganese ionMetal ion cofactor

Identifiers

PMID37202563
OpenAlexW4377012412

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.