ArticleNature communications2023
Single-frame deep-learning super-resolution microscopy for intracellular dynamics imaging.
Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
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Who cites it
54 citing papers in PubMed, 98 citations in OpenAlex.
- Quantifying the spatio-temporal image degradation under motion blur in fluorescence microscopy.Biophysical reports · 2026Article
- AI-empowered super-resolution microscopy: a revolution in nanoscale cellular imaging.Nature methods · 2026Review
- Artificial Intelligence for Discovery in Life Sciences.Bioconjugate chemistry · 2026Review
- Combined TIRF and 3D Super-Resolution Microscopy for Nanoscopic Characterization of Adhesion Molecules on Microvilli.Analytical chemistry · 2026Article
- Bridging annotated microscopy imaging data and analysis method development for scientific discovery.Patterns (New York, N.Y.) · 2026Review
- O-SNAP uncovers nanoscale chromatin remodeling in dedifferentiation and stress responses.Nature communications · 2026Article
- Pushing the limits of fluorescence imaging with a restoration neural network aggregating large-view statistics.Nature communications · 2026Article
- The SDF-1α/CXCR4 axis regulates chondrocyte mitochondrial dynamics via the ERK/AMPKα pathway.Cell communication and signaling : CCS · 2026Article
- High-fidelity single-frame computational super-resolution using signal-preserving denoising-enabled deconvolution.Nature communications · 2026Article
- A foundation model for multi-task cross-distribution restoration of fluorescence microscopy images.Nature communications · 2026Article
- Seeing the Unseen: Super-Resolution Microscopy in Protein Aggregation Research.Chemical & biomedical imaging · 2026Review
- Self-adaptive fine-tuning of deep learning super-resolution microscopy for artifact suppression in live-cell imaging.Innovation (Cambridge (Mass.)) · 2026Article
- High-speed blind structured illumination microscopy via unsupervised algorithm unrolling.Nature communications · 2026Article
- Self-Driving Microscopes: AI Meets Super-Resolution Microscopy.Small methods · 2026Review
- Stress transmission towards the nucleus of the cell.Frontiers in cell and developmental biology · 2026Review
- LensPlus: a high space-bandwidth optical imaging technique.Biomedical optics express · 2026Article
- Advanced Imaging for Live-Cell Spatiotemporal Monitoring: Technologies and Applications.Research (Washington, D.C.) · 2026Review
- Artificial Neural Networks for Bioimage Analysis.Methods in molecular biology (Clifton, N.J.) · 2026Article
- Technological advances in visualizing and rewiring microtubules during plant development.Journal of experimental botany · 2025Review
- Rotating Gold Nanomotors for High-Resolution Mapping of Subcellular Nanomotions.Small methods · 2025Article
Corrections and comments
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Authors and funding
15 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Single-molecule localization microscopy (SMLM) can be used to resolve subcellular structures and achieve a tenfold improvement in spatial resolution compared to that obtained by conventional fluorescence microscopy. However, the separation of single-molecule fluorescence events that requires thousands of frames dramatically increases the image acquisition time and phototoxicity, impeding the observation of instantaneous intracellular dynamics. Here we develop a deep-learning based single-frame super-resolution microscopy (SFSRM) method which utilizes a subpixel edge map and a multicomponent optimization strategy to guide the neural network to reconstruct a super-resolution image from a single frame of a diffraction-limited image. Under a tolerable signal density and an affordable signal-to-noise ratio, SFSRM enables high-fidelity live-cell imaging with spatiotemporal resolutions of 30 nm and 10 ms, allowing for prolonged monitoring of subcellular dynamics such as interplays between mitochondria and endoplasmic reticulum, the vesicle transport along microtubules, and the endosome fusion and fission. Moreover, its adaptability to different microscopes and spectra makes it a useful tool for various imaging systems.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.