Evidence map›Paper›PMID 37202397›Full record

ArticleNature communications2023

Association of gout with brain reserve and vulnerability to neurodegenerative disease.

Anya Topiwala, Kulveer Mankia, Steven Bell, Alastair Webb, Klaus P Ebmeier, Isobel Howard, Chaoyue Wang, Fidel Alfaro-Almagro, Karla Miller, Stephen Burgess and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 2 pooled it
4.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 23 citations in OpenAlex.

  1. Pooled it
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  6. Frontiers in pharmacology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

Anya TopiwalaNuffield Department of Population Health, Big Data Institute, University of Oxford, Oxford, UK. anya.topiwala@bdi.ox.ac.uk.ORCID 0000-0002-8408-0372
Kulveer MankiaLeeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds and NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals NHS Trust, Chapel Allerton Hospital, Leeds, UK.
Steven BellDepartment of Clinical Neurosciences, School of Clinical Medicine, University of Cambridge, Cambridge, UK.ORCID 0000-0001-6774-3149
Alastair WebbWolfson Centre for Prevention of Stroke and Dementia, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
Klaus P EbmeierDepartment of Psychiatry, University of Oxford, Warneford Hospital, Oxford, UK.ORCID 0000-0002-5190-7038
Isobel HowardNuffield Department of Population Health, Big Data Institute, University of Oxford, Oxford, UK.ORCID 0000-0001-7401-0699
Chaoyue WangWellcome Centre for Integrative Neuroimaging (WIN FMRIB), Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.ORCID 0000-0001-9402-1563
Fidel Alfaro-AlmagroWellcome Centre for Integrative Neuroimaging (WIN FMRIB), Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
Karla MillerWellcome Centre for Integrative Neuroimaging (WIN FMRIB), Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.ORCID 0000-0002-2511-3189
Stephen BurgessMRC Biostatistics Unit, School of Clinical Medicine, University of Cambridge, Cambridge, UK.ORCID 0000-0001-5365-8760
Stephen SmithWellcome Centre for Integrative Neuroimaging (WIN FMRIB), Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
Thomas E NicholsNuffield Department of Population Health, Big Data Institute, University of Oxford, Oxford, UK.ORCID 0000-0002-4516-5103
University of Oxford · GBUniversity of Cambridge · GBRuijin Hospital · CNUniversity of Leeds · GBWarneford Hospital · GB

Funding

Spatial inference methods for image analysisR01EB026859 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SCHWARTZMAN, ARMIN · 2019 to 2022
$1.7M
British Heart Foundation RG/16/4/32218Medical Research Council G1001354Medical Research Council MC_UU_00002/7NIBIB NIH HHS R01 EB026859Wellcome Trust 100309/Z/12/ZWellcome Trust 202788/Z/16/ZWellcome Trust 204623Wellcome Trust 204623/Z/16/ZWellcome Trust 215573Wellcome Trust 215573/Z/19/ZWellcome Trust 216462
6 · The paper itself

Abstract

Studies of neurodegenerative disease risk in gout are contradictory. Relationships with neuroimaging markers of brain structure, which may offer insights, are uncertain. Here we investigated associations between gout, brain structure, and neurodegenerative disease incidence. Gout patients had smaller global and regional brain volumes and markers of higher brain iron, using both observational and genetic approaches. Participants with gout also had higher incidence of all-cause dementia, Parkinson's disease, and probable essential tremor. Risks were strongly time dependent, whereby associations with incident dementia were highest in the first 3 years after gout diagnosis. These findings suggest gout is causally related to several measures of brain structure. Lower brain reserve amongst gout patients may explain their higher vulnerability to multiple neurodegenerative diseases. Motor and cognitive impairments may affect gout patients, particularly in early years after diagnosis.

Indexed as

Cognitive ReserveDementiaGoutNeurodegenerative DiseasesBrainHumans

Identifiers

PMID37202397
PMCPMC10195870
OpenAlexW4377094730

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.