Evidence map›Paper›PMID 37202378›Full record

ReviewNature reviews. Disease primers2023

Child and adolescent obesity.

Natalie B Lister, Louise A Baur, Janine F Felix, Andrew J Hill, Claude Marcus, Thomas Reinehr, Carolyn Summerbell, Martin Wabitsch

Registry-linked trialOpen access · bronzeAbstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Disease primers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06562465 (Research on Prevention and Intervention of Overweight and Obesity in Preschool Children), which is not on this map. Cited by 316 papers, 20 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
316citing papers in PubMed, 20 pooled it
121.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06562465 narecruitingnot on this mapstarted 2024, after this paper: background citation

Research on Prevention and Intervention of Overweight and Obesity in Preschool Children

TypeinterventionalSponsorChen LiRan2024 to 2025Enrolled174ConditionsOverweight and ObesityArmsdietary and exercise management, no dietary and exercise management
3 · Its place in the literature

Who cites it

316 citing papers in PubMed, 20 syntheses or guidelines pooled it, 419 citations in OpenAlex.

  1. Cognitive Behavioral Interventions for Children and Adolescents With Overweight or Obesity: A Systematic Review and Component Network Meta-Analysis.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2026
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  15. CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2025
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  16. Interventions to prevent obesity in children aged 2 to 4 years old.The Cochrane database of systematic reviews · 2025
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  17. Managing obesity in children: a clinical practice guideline.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2025
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256 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 5 countries.

Natalie B ListerChildren's Hospital Westmead Clinical School, Sydney Medical School, The University of Sydney, Sydney, New South Wales, Australia.ORCID 0000-0002-9148-8632
Louise A BaurChildren's Hospital Westmead Clinical School, Sydney Medical School, The University of Sydney, Sydney, New South Wales, Australia. Louise.Baur@sydney.edu.au.ORCID 0000-0002-4521-9482
Janine F FelixThe Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands.
Andrew J HillInstitute of Health Sciences, School of Medicine, University of Leeds, Leeds, UK.ORCID 0000-0003-3192-0427
Claude MarcusDivision of Paediatrics, Department of Clinical Science Intervention and Technology, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden.ORCID 0000-0003-0890-2650
Thomas ReinehrVestische Hospital for Children and Adolescents Datteln, University of Witten/Herdecke, Datteln, Germany.ORCID 0000-0002-4351-1834
Carolyn SummerbellDepartment of Sport and Exercise Sciences, Durham University, Durham, UK.
Martin WabitschDivision of Paediatric Endocrinology and Diabetes, Department of Paediatrics and Adolescent Medicine, Ulm University Medical Centre, Ulm, Germany.ORCID 0000-0001-6795-8430
The University of Sydney · AUDurham University · GBErasmus MC · NLKarolinska University Hospital · SEUniversity of Leeds · GBWitten/Herdecke University · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The prevalence of child and adolescent obesity has plateaued at high levels in most high-income countries and is increasing in many low-income and middle-income countries. Obesity arises when a mix of genetic and epigenetic factors, behavioural risk patterns and broader environmental and sociocultural influences affect the two body weight regulation systems: energy homeostasis, including leptin and gastrointestinal tract signals, operating predominantly at an unconscious level, and cognitive-emotional control that is regulated by higher brain centres, operating at a conscious level. Health-related quality of life is reduced in those with obesity. Comorbidities of obesity, including type 2 diabetes mellitus, fatty liver disease and depression, are more likely in adolescents and in those with severe obesity. Treatment incorporates a respectful, stigma-free and family-based approach involving multiple components, and addresses dietary, physical activity, sedentary and sleep behaviours. In adolescents in particular, adjunctive therapies can be valuable, such as more intensive dietary therapies, pharmacotherapy and bariatric surgery. Prevention of obesity requires a whole-system approach and joined-up policy initiatives across government departments. Development and implementation of interventions to prevent paediatric obesity in children should focus on interventions that are feasible, effective and likely to reduce gaps in health inequalities.

Indexed as

Diabetes Mellitus, Type 2Pediatric ObesityAdolescentChildComorbidityDietHumansQuality of Life

Identifiers

PMID37202378
OpenAlexW4377028102

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.