ArticleNeurology2023
β-Amyloid Load on PET Along the Continuum of Dementia With Lewy Bodies.
Open access · greenAbstract read
In one paragraph
Article in Neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
4.9field-weighted citation impact, top 4% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- Sex differences inFrontiers in dementia · 2025Pooled it
- Co- and Multi-Pathologies in Parkinson's Disease: An International Parkinson and Movement Disorder Society Scientific Issues Committee Review.Movement disorders : official journal of the Movement Disorder Society · 2026Review
- Discordance Between Striatal Dopaminergic Imaging and Motor Performances in REM Sleep Behavior Disorder.Neurology open access · 2026Article
- Metabolic brain networks in dementia with Lewy bodies: from prodromal to manifest disease stages.Journal of neurology, neurosurgery, and psychiatry · 2026Article
- CSF elevated Tau and P-Tau and normal Aβ42 mainly corresponds to Alzheimer's disease with dementia with Lewy bodies.GeroScience · 2026Article
- Concurrent detection of cognitive impairment and amyloid positivity with a multimodal machine learning-enabled digital cognitive assessment.Alzheimer's research & therapy · 2025Article
- Cholinergic basal forebrain degeneration in isolated REM sleep behaviour disorder.Brain : a journal of neurology · 2025Article
- Plasma p-tau217 and Aβ42/40 as markers of Aβ pathology in the Lewy body continuum.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Dementia with Lewy bodies and Parkinson disease dementia - the same or different and is it important?Nature reviews. Neurology · 2025Review
- Use of Amyloid Positron-Emission Tomography to Diagnose Alzheimer's Disease in Clinical Practice in South Korea: Expert Recommendations.Journal of clinical neurology (Seoul, Korea) · 2025Review
- Implications and opportunities regarding biological frameworks in overt and prodromal dementia with Lewy bodies.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Review
- Cortical microstructural abnormalities in dementia with Lewy bodies and their associations with Alzheimer's disease copathologies.NPJ Parkinson's disease · 2025Article
- Cerebral microbleeds: prevalence and relationship to clinical features in cognitive impairment with lewy body disease.BMC neurology · 2025Article
- A Narrative Review on Biochemical Markers and Emerging Treatments in Prodromal Synucleinopathies.Clinics and practice · 2025Review
- Tau PET positivity predicts clinically relevant cognitive decline driven by Alzheimer's disease compared to comorbid cases; proof of concept in the ADNI study.Molecular psychiatry · 2025Article
- The role ofFrontiers in neuroscience · 2025Review
- Cognitive Impact of β-Amyloid Load in the Rapid Eye Movement Sleep Behavior Disorder-Lewy Body Disease Continuum.Movement disorders : official journal of the Movement Disorder Society · 2024Article
- Influences of amyloid-β and tau on white matter neurite alterations in dementia with Lewy bodies.NPJ Parkinson's disease · 2024Article
- Plasma biomarkers of Alzheimer's disease in the continuum of dementia with Lewy bodies.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Parkinson's Disease and Dementia with Lewy Bodies: One and the Same.Journal of Parkinson's disease · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
28 authors at 3 institutions in 1 country.
Patricia Diaz-GalvanFrom the Department of Radiology (P.D.-G., C.G.S., M.L.S., J.L.G., C.R.J., H.-K.P.M., V.J.L., K.K.), Department of Quantitative Health Sciences (S.A.P., T.G.L., R.C.P.), and Department of Information Technology (M.L.S.), Mayo Clinic, Rochester, MN; Department of Radiology (M.J.), Mayo Clinic, Jacksonville, FL; Department of Neurology (T.M., L.K.F., R.S., J.G.-R., D.T.J., H.B., E.K.S.L., D.S.K., V.K.R., R.C.P., B.F.B.), Department of Psychiatry and Psychology (J.A.F., E.K.S.L.), and Center for Sleep Medicine (E.K.S.L.), Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic, Rochester, MN; Mayo Clinic Health System Southwest Wisconsin (E.K.S.L.), La Crosse; Department of Neuroscience (O.R.), Department of Neurology (N.G.-R., G.S.D.), Laboratory of Medicine and Pathology (D.W.D.), and Department of Psychiatry and Psychology (T.J.F.), Mayo Clinic, Jacksonville, FL.
Scott A PrzybelskiFrom the Department of Radiology (P.D.-G., C.G.S., M.L.S., J.L.G., C.R.J., H.-K.P.M., V.J.L., K.K.), Department of Quantitative Health Sciences (S.A.P., T.G.L., R.C.P.), and Department of Information Technology (M.L.S.), Mayo Clinic, Rochester, MN; Department of Radiology (M.J.), Mayo Clinic, Jacksonville, FL; Department of Neurology (T.M., L.K.F., R.S., J.G.-R., D.T.J., H.B., E.K.S.L., D.S.K., V.K.R., R.C.P., B.F.B.), Department of Psychiatry and Psychology (J.A.F., E.K.S.L.), and Center for Sleep Medicine (E.K.S.L.), Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic, Rochester, MN; Mayo Clinic Health System Southwest Wisconsin (E.K.S.L.), La Crosse; Department of Neuroscience (O.R.), Department of Neurology (N.G.-R., G.S.D.), Laboratory of Medicine and Pathology (D.W.D.), and Department of Psychiatry and Psychology (T.J.F.), Mayo Clinic, Jacksonville, FL.
Timothy G LesnickFrom the Department of Radiology (P.D.-G., C.G.S., M.L.S., J.L.G., C.R.J., H.-K.P.M., V.J.L., K.K.), Department of Quantitative Health Sciences (S.A.P., T.G.L., R.C.P.), and Department of Information Technology (M.L.S.), Mayo Clinic, Rochester, MN; Department of Radiology (M.J.), Mayo Clinic, Jacksonville, FL; Department of Neurology (T.M., L.K.F., R.S., J.G.-R., D.T.J., H.B., E.K.S.L., D.S.K., V.K.R., R.C.P., B.F.B.), Department of Psychiatry and Psychology (J.A.F., E.K.S.L.), and Center for Sleep Medicine (E.K.S.L.), Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic, Rochester, MN; Mayo Clinic Health System Southwest Wisconsin (E.K.S.L.), La Crosse; Department of Neuroscience (O.R.), Department of Neurology (N.G.-R., G.S.D.), Laboratory of Medicine and Pathology (D.W.D.), and Department of Psychiatry and Psychology (T.J.F.), Mayo Clinic, Jacksonville, FL.
Christopher G SchwarzFrom the Department of Radiology (P.D.-G., C.G.S., M.L.S., J.L.G., C.R.J., H.-K.P.M., V.J.L., K.K.), Department of Quantitative Health Sciences (S.A.P., T.G.L., R.C.P.), and Department of Information Technology (M.L.S.), Mayo Clinic, Rochester, MN; Department of Radiology (M.J.), Mayo Clinic, Jacksonville, FL; Department of Neurology (T.M., L.K.F., R.S., J.G.-R., D.T.J., H.B., E.K.S.L., D.S.K., V.K.R., R.C.P., B.F.B.), Department of Psychiatry and Psychology (J.A.F., E.K.S.L.), and Center for Sleep Medicine (E.K.S.L.), Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic, Rochester, MN; Mayo Clinic Health System Southwest Wisconsin (E.K.S.L.), La Crosse; Department of Neuroscience (O.R.), Department of Neurology (N.G.-R., G.S.D.), Laboratory of Medicine and Pathology (D.W.D.), and Department of Psychiatry and Psychology (T.J.F.), Mayo Clinic, Jacksonville, FL.ORCID 0000-0002-1466-8357
Matthew L SenjemFrom the Department of Radiology (P.D.-G., C.G.S., M.L.S., J.L.G., C.R.J., H.-K.P.M., V.J.L., K.K.), Department of Quantitative Health Sciences (S.A.P., T.G.L., R.C.P.), and Department of Information Technology (M.L.S.), Mayo Clinic, Rochester, MN; Department of Radiology (M.J.), Mayo Clinic, Jacksonville, FL; Department of Neurology (T.M., L.K.F., R.S., J.G.-R., D.T.J., H.B., E.K.S.L., D.S.K., V.K.R., R.C.P., B.F.B.), Department of Psychiatry and Psychology (J.A.F., E.K.S.L.), and Center for Sleep Medicine (E.K.S.L.), Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic, Rochester, MN; Mayo Clinic Health System Southwest Wisconsin (E.K.S.L.), La Crosse; Department of Neuroscience (O.R.), Department of Neurology (N.G.-R., G.S.D.), Laboratory of Medicine and Pathology (D.W.D.), and Department of Psychiatry and Psychology (T.J.F.), Mayo Clinic, Jacksonville, FL.ORCID 0000-0001-9308-9275
Jeffrey L GunterFrom the Department of Radiology (P.D.-G., C.G.S., M.L.S., J.L.G., C.R.J., H.-K.P.M., V.J.L., K.K.), Department of Quantitative Health Sciences (S.A.P., T.G.L., R.C.P.), and Department of Information Technology (M.L.S.), Mayo Clinic, Rochester, MN; Department of Radiology (M.J.), Mayo Clinic, Jacksonville, FL; Department of Neurology (T.M., L.K.F., R.S., J.G.-R., D.T.J., H.B., E.K.S.L., D.S.K., V.K.R., R.C.P., B.F.B.), Department of Psychiatry and Psychology (J.A.F., E.K.S.L.), and Center for Sleep Medicine (E.K.S.L.), Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic, Rochester, MN; Mayo Clinic Health System Southwest Wisconsin (E.K.S.L.), La Crosse; Department of Neuroscience (O.R.), Department of Neurology (N.G.-R., G.S.D.), Laboratory of Medicine and Pathology (D.W.D.), and Department of Psychiatry and Psychology (T.J.F.), Mayo Clinic, Jacksonville, FL.
Clifford R JackFrom the Department of Radiology (P.D.-G., C.G.S., M.L.S., J.L.G., C.R.J., H.-K.P.M., V.J.L., K.K.), Department of Quantitative Health Sciences (S.A.P., T.G.L., R.C.P.), and Department of Information Technology (M.L.S.), Mayo Clinic, Rochester, MN; Department of Radiology (M.J.), Mayo Clinic, Jacksonville, FL; Department of Neurology (T.M., L.K.F., R.S., J.G.-R., D.T.J., H.B., E.K.S.L., D.S.K., V.K.R., R.C.P., B.F.B.), Department of Psychiatry and Psychology (J.A.F., E.K.S.L.), and Center for Sleep Medicine (E.K.S.L.), Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic, Rochester, MN; Mayo Clinic Health System Southwest Wisconsin (E.K.S.L.), La Crosse; Department of Neuroscience (O.R.), Department of Neurology (N.G.-R., G.S.D.), Laboratory of Medicine and Pathology (D.W.D.), and Department of Psychiatry and Psychology (T.J.F.), Mayo Clinic, Jacksonville, FL.ORCID 0000-0001-7916-622X
Hoon-Ki Paul MinFrom the Department of Radiology (P.D.-G., C.G.S., M.L.S., J.L.G., C.R.J., H.-K.P.M., V.J.L., K.K.), Department of Quantitative Health Sciences (S.A.P., T.G.L., R.C.P.), and Department of Information Technology (M.L.S.), Mayo Clinic, Rochester, MN; Department of Radiology (M.J.), Mayo Clinic, Jacksonville, FL; Department of Neurology (T.M., L.K.F., R.S., J.G.-R., D.T.J., H.B., E.K.S.L., D.S.K., V.K.R., R.C.P., B.F.B.), Department of Psychiatry and Psychology (J.A.F., E.K.S.L.), and Center for Sleep Medicine (E.K.S.L.), Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic, Rochester, MN; Mayo Clinic Health System Southwest Wisconsin (E.K.S.L.), La Crosse; Department of Neuroscience (O.R.), Department of Neurology (N.G.-R., G.S.D.), Laboratory of Medicine and Pathology (D.W.D.), and Department of Psychiatry and Psychology (T.J.F.), Mayo Clinic, Jacksonville, FL.ORCID 0000-0002-1084-2469
Manoj JainFrom the Department of Radiology (P.D.-G., C.G.S., M.L.S., J.L.G., C.R.J., H.-K.P.M., V.J.L., K.K.), Department of Quantitative Health Sciences (S.A.P., T.G.L., R.C.P.), and Department of Information Technology (M.L.S.), Mayo Clinic, Rochester, MN; Department of Radiology (M.J.), Mayo Clinic, Jacksonville, FL; Department of Neurology (T.M., L.K.F., R.S., J.G.-R., D.T.J., H.B., E.K.S.L., D.S.K., V.K.R., R.C.P., B.F.B.), Department of Psychiatry and Psychology (J.A.F., E.K.S.L.), and Center for Sleep Medicine (E.K.S.L.), Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic, Rochester, MN; Mayo Clinic Health System Southwest Wisconsin (E.K.S.L.), La Crosse; Department of Neuroscience (O.R.), Department of Neurology (N.G.-R., G.S.D.), Laboratory of Medicine and Pathology (D.W.D.), and Department of Psychiatry and Psychology (T.J.F.), Mayo Clinic, Jacksonville, FL.
Toji MiyagawaFrom the Department of Radiology (P.D.-G., C.G.S., M.L.S., J.L.G., C.R.J., H.-K.P.M., V.J.L., K.K.), Department of Quantitative Health Sciences (S.A.P., T.G.L., R.C.P.), and Department of Information Technology (M.L.S.), Mayo Clinic, Rochester, MN; Department of Radiology (M.J.), Mayo Clinic, Jacksonville, FL; Department of Neurology (T.M., L.K.F., R.S., J.G.-R., D.T.J., H.B., E.K.S.L., D.S.K., V.K.R., R.C.P., B.F.B.), Department of Psychiatry and Psychology (J.A.F., E.K.S.L.), and Center for Sleep Medicine (E.K.S.L.), Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic, Rochester, MN; Mayo Clinic Health System Southwest Wisconsin (E.K.S.L.), La Crosse; Department of Neuroscience (O.R.), Department of Neurology (N.G.-R., G.S.D.), Laboratory of Medicine and Pathology (D.W.D.), and Department of Psychiatry and Psychology (T.J.F.), Mayo Clinic, Jacksonville, FL.
Leah K ForsbergFrom the Department of Radiology (P.D.-G., C.G.S., M.L.S., J.L.G., C.R.J., H.-K.P.M., V.J.L., K.K.), Department of Quantitative Health Sciences (S.A.P., T.G.L., R.C.P.), and Department of Information Technology (M.L.S.), Mayo Clinic, Rochester, MN; Department of Radiology (M.J.), Mayo Clinic, Jacksonville, FL; Department of Neurology (T.M., L.K.F., R.S., J.G.-R., D.T.J., H.B., E.K.S.L., D.S.K., V.K.R., R.C.P., B.F.B.), Department of Psychiatry and Psychology (J.A.F., E.K.S.L.), and Center for Sleep Medicine (E.K.S.L.), Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic, Rochester, MN; Mayo Clinic Health System Southwest Wisconsin (E.K.S.L.), La Crosse; Department of Neuroscience (O.R.), Department of Neurology (N.G.-R., G.S.D.), Laboratory of Medicine and Pathology (D.W.D.), and Department of Psychiatry and Psychology (T.J.F.), Mayo Clinic, Jacksonville, FL.
Julie A FieldsFrom the Department of Radiology (P.D.-G., C.G.S., M.L.S., J.L.G., C.R.J., H.-K.P.M., V.J.L., K.K.), Department of Quantitative Health Sciences (S.A.P., T.G.L., R.C.P.), and Department of Information Technology (M.L.S.), Mayo Clinic, Rochester, MN; Department of Radiology (M.J.), Mayo Clinic, Jacksonville, FL; Department of Neurology (T.M., L.K.F., R.S., J.G.-R., D.T.J., H.B., E.K.S.L., D.S.K., V.K.R., R.C.P., B.F.B.), Department of Psychiatry and Psychology (J.A.F., E.K.S.L.), and Center for Sleep Medicine (E.K.S.L.), Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic, Rochester, MN; Mayo Clinic Health System Southwest Wisconsin (E.K.S.L.), La Crosse; Department of Neuroscience (O.R.), Department of Neurology (N.G.-R., G.S.D.), Laboratory of Medicine and Pathology (D.W.D.), and Department of Psychiatry and Psychology (T.J.F.), Mayo Clinic, Jacksonville, FL.
Rodolfo SavicaFrom the Department of Radiology (P.D.-G., C.G.S., M.L.S., J.L.G., C.R.J., H.-K.P.M., V.J.L., K.K.), Department of Quantitative Health Sciences (S.A.P., T.G.L., R.C.P.), and Department of Information Technology (M.L.S.), Mayo Clinic, Rochester, MN; Department of Radiology (M.J.), Mayo Clinic, Jacksonville, FL; Department of Neurology (T.M., L.K.F., R.S., J.G.-R., D.T.J., H.B., E.K.S.L., D.S.K., V.K.R., R.C.P., B.F.B.), Department of Psychiatry and Psychology (J.A.F., E.K.S.L.), and Center for Sleep Medicine (E.K.S.L.), Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic, Rochester, MN; Mayo Clinic Health System Southwest Wisconsin (E.K.S.L.), La Crosse; Department of Neuroscience (O.R.), Department of Neurology (N.G.-R., G.S.D.), Laboratory of Medicine and Pathology (D.W.D.), and Department of Psychiatry and Psychology (T.J.F.), Mayo Clinic, Jacksonville, FL.ORCID 0000-0002-2543-0627
Jonathan Graff-RadfordFrom the Department of Radiology (P.D.-G., C.G.S., M.L.S., J.L.G., C.R.J., H.-K.P.M., V.J.L., K.K.), Department of Quantitative Health Sciences (S.A.P., T.G.L., R.C.P.), and Department of Information Technology (M.L.S.), Mayo Clinic, Rochester, MN; Department of Radiology (M.J.), Mayo Clinic, Jacksonville, FL; Department of Neurology (T.M., L.K.F., R.S., J.G.-R., D.T.J., H.B., E.K.S.L., D.S.K., V.K.R., R.C.P., B.F.B.), Department of Psychiatry and Psychology (J.A.F., E.K.S.L.), and Center for Sleep Medicine (E.K.S.L.), Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic, Rochester, MN; Mayo Clinic Health System Southwest Wisconsin (E.K.S.L.), La Crosse; Department of Neuroscience (O.R.), Department of Neurology (N.G.-R., G.S.D.), Laboratory of Medicine and Pathology (D.W.D.), and Department of Psychiatry and Psychology (T.J.F.), Mayo Clinic, Jacksonville, FL.
David T JonesFrom the Department of Radiology (P.D.-G., C.G.S., M.L.S., J.L.G., C.R.J., H.-K.P.M., V.J.L., K.K.), Department of Quantitative Health Sciences (S.A.P., T.G.L., R.C.P.), and Department of Information Technology (M.L.S.), Mayo Clinic, Rochester, MN; Department of Radiology (M.J.), Mayo Clinic, Jacksonville, FL; Department of Neurology (T.M., L.K.F., R.S., J.G.-R., D.T.J., H.B., E.K.S.L., D.S.K., V.K.R., R.C.P., B.F.B.), Department of Psychiatry and Psychology (J.A.F., E.K.S.L.), and Center for Sleep Medicine (E.K.S.L.), Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic, Rochester, MN; Mayo Clinic Health System Southwest Wisconsin (E.K.S.L.), La Crosse; Department of Neuroscience (O.R.), Department of Neurology (N.G.-R., G.S.D.), Laboratory of Medicine and Pathology (D.W.D.), and Department of Psychiatry and Psychology (T.J.F.), Mayo Clinic, Jacksonville, FL.ORCID 0000-0002-4807-9833
Hugo BothaFrom the Department of Radiology (P.D.-G., C.G.S., M.L.S., J.L.G., C.R.J., H.-K.P.M., V.J.L., K.K.), Department of Quantitative Health Sciences (S.A.P., T.G.L., R.C.P.), and Department of Information Technology (M.L.S.), Mayo Clinic, Rochester, MN; Department of Radiology (M.J.), Mayo Clinic, Jacksonville, FL; Department of Neurology (T.M., L.K.F., R.S., J.G.-R., D.T.J., H.B., E.K.S.L., D.S.K., V.K.R., R.C.P., B.F.B.), Department of Psychiatry and Psychology (J.A.F., E.K.S.L.), and Center for Sleep Medicine (E.K.S.L.), Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic, Rochester, MN; Mayo Clinic Health System Southwest Wisconsin (E.K.S.L.), La Crosse; Department of Neuroscience (O.R.), Department of Neurology (N.G.-R., G.S.D.), Laboratory of Medicine and Pathology (D.W.D.), and Department of Psychiatry and Psychology (T.J.F.), Mayo Clinic, Jacksonville, FL.
Erik K St LouisFrom the Department of Radiology (P.D.-G., C.G.S., M.L.S., J.L.G., C.R.J., H.-K.P.M., V.J.L., K.K.), Department of Quantitative Health Sciences (S.A.P., T.G.L., R.C.P.), and Department of Information Technology (M.L.S.), Mayo Clinic, Rochester, MN; Department of Radiology (M.J.), Mayo Clinic, Jacksonville, FL; Department of Neurology (T.M., L.K.F., R.S., J.G.-R., D.T.J., H.B., E.K.S.L., D.S.K., V.K.R., R.C.P., B.F.B.), Department of Psychiatry and Psychology (J.A.F., E.K.S.L.), and Center for Sleep Medicine (E.K.S.L.), Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic, Rochester, MN; Mayo Clinic Health System Southwest Wisconsin (E.K.S.L.), La Crosse; Department of Neuroscience (O.R.), Department of Neurology (N.G.-R., G.S.D.), Laboratory of Medicine and Pathology (D.W.D.), and Department of Psychiatry and Psychology (T.J.F.), Mayo Clinic, Jacksonville, FL.
David S KnopmanFrom the Department of Radiology (P.D.-G., C.G.S., M.L.S., J.L.G., C.R.J., H.-K.P.M., V.J.L., K.K.), Department of Quantitative Health Sciences (S.A.P., T.G.L., R.C.P.), and Department of Information Technology (M.L.S.), Mayo Clinic, Rochester, MN; Department of Radiology (M.J.), Mayo Clinic, Jacksonville, FL; Department of Neurology (T.M., L.K.F., R.S., J.G.-R., D.T.J., H.B., E.K.S.L., D.S.K., V.K.R., R.C.P., B.F.B.), Department of Psychiatry and Psychology (J.A.F., E.K.S.L.), and Center for Sleep Medicine (E.K.S.L.), Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic, Rochester, MN; Mayo Clinic Health System Southwest Wisconsin (E.K.S.L.), La Crosse; Department of Neuroscience (O.R.), Department of Neurology (N.G.-R., G.S.D.), Laboratory of Medicine and Pathology (D.W.D.), and Department of Psychiatry and Psychology (T.J.F.), Mayo Clinic, Jacksonville, FL.
Vijay K RamananFrom the Department of Radiology (P.D.-G., C.G.S., M.L.S., J.L.G., C.R.J., H.-K.P.M., V.J.L., K.K.), Department of Quantitative Health Sciences (S.A.P., T.G.L., R.C.P.), and Department of Information Technology (M.L.S.), Mayo Clinic, Rochester, MN; Department of Radiology (M.J.), Mayo Clinic, Jacksonville, FL; Department of Neurology (T.M., L.K.F., R.S., J.G.-R., D.T.J., H.B., E.K.S.L., D.S.K., V.K.R., R.C.P., B.F.B.), Department of Psychiatry and Psychology (J.A.F., E.K.S.L.), and Center for Sleep Medicine (E.K.S.L.), Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic, Rochester, MN; Mayo Clinic Health System Southwest Wisconsin (E.K.S.L.), La Crosse; Department of Neuroscience (O.R.), Department of Neurology (N.G.-R., G.S.D.), Laboratory of Medicine and Pathology (D.W.D.), and Department of Psychiatry and Psychology (T.J.F.), Mayo Clinic, Jacksonville, FL.ORCID 0000-0001-6591-8734
Owen RossFrom the Department of Radiology (P.D.-G., C.G.S., M.L.S., J.L.G., C.R.J., H.-K.P.M., V.J.L., K.K.), Department of Quantitative Health Sciences (S.A.P., T.G.L., R.C.P.), and Department of Information Technology (M.L.S.), Mayo Clinic, Rochester, MN; Department of Radiology (M.J.), Mayo Clinic, Jacksonville, FL; Department of Neurology (T.M., L.K.F., R.S., J.G.-R., D.T.J., H.B., E.K.S.L., D.S.K., V.K.R., R.C.P., B.F.B.), Department of Psychiatry and Psychology (J.A.F., E.K.S.L.), and Center for Sleep Medicine (E.K.S.L.), Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic, Rochester, MN; Mayo Clinic Health System Southwest Wisconsin (E.K.S.L.), La Crosse; Department of Neuroscience (O.R.), Department of Neurology (N.G.-R., G.S.D.), Laboratory of Medicine and Pathology (D.W.D.), and Department of Psychiatry and Psychology (T.J.F.), Mayo Clinic, Jacksonville, FL.
Neill Graff-RadfordFrom the Department of Radiology (P.D.-G., C.G.S., M.L.S., J.L.G., C.R.J., H.-K.P.M., V.J.L., K.K.), Department of Quantitative Health Sciences (S.A.P., T.G.L., R.C.P.), and Department of Information Technology (M.L.S.), Mayo Clinic, Rochester, MN; Department of Radiology (M.J.), Mayo Clinic, Jacksonville, FL; Department of Neurology (T.M., L.K.F., R.S., J.G.-R., D.T.J., H.B., E.K.S.L., D.S.K., V.K.R., R.C.P., B.F.B.), Department of Psychiatry and Psychology (J.A.F., E.K.S.L.), and Center for Sleep Medicine (E.K.S.L.), Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic, Rochester, MN; Mayo Clinic Health System Southwest Wisconsin (E.K.S.L.), La Crosse; Department of Neuroscience (O.R.), Department of Neurology (N.G.-R., G.S.D.), Laboratory of Medicine and Pathology (D.W.D.), and Department of Psychiatry and Psychology (T.J.F.), Mayo Clinic, Jacksonville, FL.
Gregory S DayFrom the Department of Radiology (P.D.-G., C.G.S., M.L.S., J.L.G., C.R.J., H.-K.P.M., V.J.L., K.K.), Department of Quantitative Health Sciences (S.A.P., T.G.L., R.C.P.), and Department of Information Technology (M.L.S.), Mayo Clinic, Rochester, MN; Department of Radiology (M.J.), Mayo Clinic, Jacksonville, FL; Department of Neurology (T.M., L.K.F., R.S., J.G.-R., D.T.J., H.B., E.K.S.L., D.S.K., V.K.R., R.C.P., B.F.B.), Department of Psychiatry and Psychology (J.A.F., E.K.S.L.), and Center for Sleep Medicine (E.K.S.L.), Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic, Rochester, MN; Mayo Clinic Health System Southwest Wisconsin (E.K.S.L.), La Crosse; Department of Neuroscience (O.R.), Department of Neurology (N.G.-R., G.S.D.), Laboratory of Medicine and Pathology (D.W.D.), and Department of Psychiatry and Psychology (T.J.F.), Mayo Clinic, Jacksonville, FL.ORCID 0000-0001-5133-5538
Dennis W DicksonFrom the Department of Radiology (P.D.-G., C.G.S., M.L.S., J.L.G., C.R.J., H.-K.P.M., V.J.L., K.K.), Department of Quantitative Health Sciences (S.A.P., T.G.L., R.C.P.), and Department of Information Technology (M.L.S.), Mayo Clinic, Rochester, MN; Department of Radiology (M.J.), Mayo Clinic, Jacksonville, FL; Department of Neurology (T.M., L.K.F., R.S., J.G.-R., D.T.J., H.B., E.K.S.L., D.S.K., V.K.R., R.C.P., B.F.B.), Department of Psychiatry and Psychology (J.A.F., E.K.S.L.), and Center for Sleep Medicine (E.K.S.L.), Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic, Rochester, MN; Mayo Clinic Health System Southwest Wisconsin (E.K.S.L.), La Crosse; Department of Neuroscience (O.R.), Department of Neurology (N.G.-R., G.S.D.), Laboratory of Medicine and Pathology (D.W.D.), and Department of Psychiatry and Psychology (T.J.F.), Mayo Clinic, Jacksonville, FL.ORCID 0000-0001-7189-7917
Tanis J FermanFrom the Department of Radiology (P.D.-G., C.G.S., M.L.S., J.L.G., C.R.J., H.-K.P.M., V.J.L., K.K.), Department of Quantitative Health Sciences (S.A.P., T.G.L., R.C.P.), and Department of Information Technology (M.L.S.), Mayo Clinic, Rochester, MN; Department of Radiology (M.J.), Mayo Clinic, Jacksonville, FL; Department of Neurology (T.M., L.K.F., R.S., J.G.-R., D.T.J., H.B., E.K.S.L., D.S.K., V.K.R., R.C.P., B.F.B.), Department of Psychiatry and Psychology (J.A.F., E.K.S.L.), and Center for Sleep Medicine (E.K.S.L.), Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic, Rochester, MN; Mayo Clinic Health System Southwest Wisconsin (E.K.S.L.), La Crosse; Department of Neuroscience (O.R.), Department of Neurology (N.G.-R., G.S.D.), Laboratory of Medicine and Pathology (D.W.D.), and Department of Psychiatry and Psychology (T.J.F.), Mayo Clinic, Jacksonville, FL.
Ronald C PetersenFrom the Department of Radiology (P.D.-G., C.G.S., M.L.S., J.L.G., C.R.J., H.-K.P.M., V.J.L., K.K.), Department of Quantitative Health Sciences (S.A.P., T.G.L., R.C.P.), and Department of Information Technology (M.L.S.), Mayo Clinic, Rochester, MN; Department of Radiology (M.J.), Mayo Clinic, Jacksonville, FL; Department of Neurology (T.M., L.K.F., R.S., J.G.-R., D.T.J., H.B., E.K.S.L., D.S.K., V.K.R., R.C.P., B.F.B.), Department of Psychiatry and Psychology (J.A.F., E.K.S.L.), and Center for Sleep Medicine (E.K.S.L.), Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic, Rochester, MN; Mayo Clinic Health System Southwest Wisconsin (E.K.S.L.), La Crosse; Department of Neuroscience (O.R.), Department of Neurology (N.G.-R., G.S.D.), Laboratory of Medicine and Pathology (D.W.D.), and Department of Psychiatry and Psychology (T.J.F.), Mayo Clinic, Jacksonville, FL.ORCID 0000-0002-8178-6601
Val J LoweFrom the Department of Radiology (P.D.-G., C.G.S., M.L.S., J.L.G., C.R.J., H.-K.P.M., V.J.L., K.K.), Department of Quantitative Health Sciences (S.A.P., T.G.L., R.C.P.), and Department of Information Technology (M.L.S.), Mayo Clinic, Rochester, MN; Department of Radiology (M.J.), Mayo Clinic, Jacksonville, FL; Department of Neurology (T.M., L.K.F., R.S., J.G.-R., D.T.J., H.B., E.K.S.L., D.S.K., V.K.R., R.C.P., B.F.B.), Department of Psychiatry and Psychology (J.A.F., E.K.S.L.), and Center for Sleep Medicine (E.K.S.L.), Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic, Rochester, MN; Mayo Clinic Health System Southwest Wisconsin (E.K.S.L.), La Crosse; Department of Neuroscience (O.R.), Department of Neurology (N.G.-R., G.S.D.), Laboratory of Medicine and Pathology (D.W.D.), and Department of Psychiatry and Psychology (T.J.F.), Mayo Clinic, Jacksonville, FL.
Brad F BoeveFrom the Department of Radiology (P.D.-G., C.G.S., M.L.S., J.L.G., C.R.J., H.-K.P.M., V.J.L., K.K.), Department of Quantitative Health Sciences (S.A.P., T.G.L., R.C.P.), and Department of Information Technology (M.L.S.), Mayo Clinic, Rochester, MN; Department of Radiology (M.J.), Mayo Clinic, Jacksonville, FL; Department of Neurology (T.M., L.K.F., R.S., J.G.-R., D.T.J., H.B., E.K.S.L., D.S.K., V.K.R., R.C.P., B.F.B.), Department of Psychiatry and Psychology (J.A.F., E.K.S.L.), and Center for Sleep Medicine (E.K.S.L.), Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic, Rochester, MN; Mayo Clinic Health System Southwest Wisconsin (E.K.S.L.), La Crosse; Department of Neuroscience (O.R.), Department of Neurology (N.G.-R., G.S.D.), Laboratory of Medicine and Pathology (D.W.D.), and Department of Psychiatry and Psychology (T.J.F.), Mayo Clinic, Jacksonville, FL.ORCID 0000-0002-4153-8187
Kejal KantarciFrom the Department of Radiology (P.D.-G., C.G.S., M.L.S., J.L.G., C.R.J., H.-K.P.M., V.J.L., K.K.), Department of Quantitative Health Sciences (S.A.P., T.G.L., R.C.P.), and Department of Information Technology (M.L.S.), Mayo Clinic, Rochester, MN; Department of Radiology (M.J.), Mayo Clinic, Jacksonville, FL; Department of Neurology (T.M., L.K.F., R.S., J.G.-R., D.T.J., H.B., E.K.S.L., D.S.K., V.K.R., R.C.P., B.F.B.), Department of Psychiatry and Psychology (J.A.F., E.K.S.L.), and Center for Sleep Medicine (E.K.S.L.), Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic, Rochester, MN; Mayo Clinic Health System Southwest Wisconsin (E.K.S.L.), La Crosse; Department of Neuroscience (O.R.), Department of Neurology (N.G.-R., G.S.D.), Laboratory of Medicine and Pathology (D.W.D.), and Department of Psychiatry and Psychology (T.J.F.), Mayo Clinic, Jacksonville, FL. kantarci.kejal@mayo.edu.
Mayo Clinic in Florida · USMayo Clinic in Arizona · USMayo Clinic · US
Funding
National Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD)U24AG021886 · NIA · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI TATIANA M. FOROUD · 2002 to 2026
$119.8MLongitudinal Imaging Biomarkers of Prodromal DLBU01NS100620 · NINDS · MAYO CLINIC ROCHESTER · PI Bradley F Boeve, KEJAL KANTARCI · 2017 to 2026
$19.2MNINDS Biomarker RepositoryU24NS095871 · NINDS · INDIANA UNIVERSITY INDIANAPOLIS · PI TATIANA M. FOROUD · 2015 to 2026
$18.3MNIA NIH HHS U24 AG021886NINDS NIH HHS U01 NS100620NINDS NIH HHS U24 NS095871
Abstract
BACKGROUND AND
objectivesβ-Amyloid (Aβ) plaques can co-occur with Lewy-related pathology in patients with dementia with Lewy bodies (DLB), but Aβ load at prodromal stages of DLB still needs to be elucidated. We investigated Aβ load on PET throughout the DLB continuum, from an early prodromal stage of isolated REM sleep behavior disorder (iRBD) to a stage of mild cognitive impairment with Lewy bodies (MCI-LB), and finally DLB.
methodsWe performed a cross-sectional study in patients with a diagnosis of iRBD, MCI-LB, or DLB from the Mayo Clinic Alzheimer Disease Research Center. Aβ levels were measured by Pittsburgh compound B (PiB) PET, and global cortical standardized uptake value ratio (SUVR) was calculated. Global cortical PiB SUVR values from each clinical group were compared with each other and with those of cognitively unimpaired (CU) individuals (n = 100) balanced on age and sex using analysis of covariance. We used multiple linear regression testing for interaction to study the influences of sex and
resultsOf the 162 patients, 16 had iRBD, 64 had MCI-LB, and 82 had DLB. Compared with CU individuals, global cortical PiB SUVR was higher in those with DLB ( DISCUSSION: In this cross-sectional study, levels of Aβ load was higher further along the DLB continuum. Whereas Aβ levels were comparable with those in CU individuals in iRBD, a significant elevation in Aβ levels was observed in the predementia stage of MCI-LB and in DLB. Specifically,
Indexed as
Alzheimer DiseaseCognitive DysfunctionLewy Body DiseaseAmyloid beta-PeptidesApolipoprotein E4Cross-Sectional StudiesFemaleHumansMalePositron-Emission TomographyAmyloid beta-PeptidesApolipoprotein E4
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.