ArticleThe European respiratory journal2023
Incidence of interstitial lung abnormalities: the MESA Lung Study.
Article in The European respiratory journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- Clinical outcomes of interstitial lung abnormalities: a systematic review and meta-analysis.Scientific reports · 2024Pooled it
- Performance of age-adjusted whole genome sequencing telomere length in idiopathic pulmonary fibrosis.American journal of respiratory and critical care medicine · 2026Article
- Cause of death in fibrotic and nonfibrotic interstitial lung abnormalities: the MESA study.American journal of respiratory and critical care medicine · 2026Article
- Next-Generation Sequencing in Pulmonary Fibrosis: Translational Promise and Current Clinical Limitations.Current issues in molecular biology · 2026Review
- Incidental pulmonary findings on CT in daily practice: the nodule and the interstitial lung abnormalities - what's old, what's new.La Radiologia medica · 2026Review
- Article
- Current diagnosis, epidemiology, and management of interstitial lung abnormalities.Frontiers in medicine · 2026Review
- Associations of High Attenuation Area-Related Proteomic Biomarkers with Fibrotic or Subpleural Interstitial Lung Abnormalities.American journal of respiratory and critical care medicine · 2025Article
- Interstitial Lung Abnormality in Health Screening Examinees: Prevalence, Outcomes, and Risk Factors.Journal of Korean medical science · 2025Article
- Review
- Quantitative Computed Tomography Measures of Lung Fibrosis and Outcomes in the National Lung Screening Trial.Annals of the American Thoracic Society · 2025Article
- Optimizing prone CT use for suspected interstitial lung abnormalities.European radiology · 2025Article
- A Comprehensive Review of Interstitial Lung Abnormalities.Respirology (Carlton, Vic.) · 2025Review
- Application of Artificial Intelligence in Thoracic Radiology: A Narrative Review.Tuberculosis and respiratory diseases · 2025Article
- Current perspectives on interstitial lung abnormalities.The Korean journal of internal medicine · 2025Review
- Genomic and Serological Rheumatoid Arthritis Biomarkers,Annals of the American Thoracic Society · 2025Article
- Development, Progression, and Mortality of Suspected Interstitial Lung Disease in COPDGene.American journal of respiratory and critical care medicine · 2024Article
- Progressive Early Interstitial Lung Abnormalities in Persons at Risk for Familial Pulmonary Fibrosis: A Prospective Cohort Study.American journal of respiratory and critical care medicine · 2024Article
- Air Pollution Exposure and Interstitial Lung Features in SPIROMICS Participants with Chronic Obstructive Pulmonary Disease.Annals of the American Thoracic Society · 2024Article
- Genetics and Genomics of Pulmonary Fibrosis: Charting the Molecular Landscape and Shaping Precision Medicine.American journal of respiratory and critical care medicine · 2024Review
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Authors and funding
25 authors at 10 institutions in 1 country.
Funding
Abstract
backgroundThe incidence of newly developed interstitial lung abnormalities (ILA) and fibrotic ILA has not been previously reported.
methodsTrained thoracic radiologists evaluated 13 944 cardiac computed tomography scans for the presence of ILA in 6197 Multi-Ethnic Study of Atherosclerosis (MESA) longitudinal cohort study participants >45 years of age from 2000 to 2012. Five percent of the scans were re-read by the same or a different observer in a blinded fashion. After exclusion of participants with ILA at baseline, incidence rates and incidence rate ratios for ILA and fibrotic ILA were calculated.
resultsThe intra-reader agreement of ILA was 92.0% (Gwet's AC1 0.912, intraclass correlation coefficient (ICC) 0.982) and the inter-reader agreement of ILA was 83.5% (Gwet's AC1 0.814, ICC 0.969). Incidence of ILA and fibrotic ILA was estimated to be 13.1 and 3.5 cases per 1000 person-years, respectively. In multivariable analyses, age (hazard ratio (HR) 1.06 (95% CI 1.05-1.08); p<0.001 and HR 1.08 (95% CI 1.06-1.11); p<0.001), high attenuation area at baseline (HR 1.05 (95% CI 1.03-1.07); p<0.001 and HR 1.06 (95% CI 1.02-1.10); p=0.002) and the
conclusionsIncident ILA and fibrotic ILA were estimated by review of cardiac imaging studies. These findings may lead to wider application of a screening tool for atherosclerosis to identify pre-clinical lung disease.
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Registered trials
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