ReviewPediatric obesity2023
Paediatric obesity and metabolic syndrome associations with cognition and the brain in youth: Current evidence and future directions.
Review in Pediatric obesity, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Brain structural and functional changes in childhood and adolescent obesity: a systematic review of MRI studies.Frontiers in human neuroscience · 2026Pooled it
- Effects of obesity on brain health and cognition.Nature reviews. Neurology · 2026Review
- Diet, lifestyle, metabolic markers, and socioeconomic status are associated with cognitive function in school-aged children from a population-based cohort.Pediatric research · 2026Article
- Altered effective connectivity between the prefrontal cortex and caudate in children with overweight and obesity.International journal of obesity (2005) · 2026Article
- Associations of Maternal Pre-Pregnancy BMI With Frontostriatal Connectivity in Young Children.Pediatric obesity · 2026Article
- The obesity-brain axis: a comprehensive review of neurological complications and therapeutic interventions in metabolic syndrome.Diabetology & metabolic syndrome · 2026Review
- Dietary patterns and neuropsychological function in adolescents: a cross-sectional and longitudinal study.BMC medicine · 2026Article
- Oxidative Stress, Antioxidant Cofactor Micronutrients, and Cognitive Outcomes in Childhood Obesity: Mechanisms, Evidence, and Therapeutic Opportunities.International journal of molecular sciences · 2025Review
- Impaired Attention Functioning in Children and Adolescents with Obesity: Preliminary Results Based on the Computerized Continuous Performance Test.Journal of clinical medicine · 2025Article
- Neural correlates of inhibitory control during a simple food go/no-go task in adolescents varying in familial obesity risk.NeuroImage · 2025Article
- Executive functioning difficulties in relation to food addiction, disordered eating attitudes, and metabolic syndrome markers among adolescents seeking obesity treatment: a cross-sectional analysis.Journal of eating disorders · 2025Article
- Neural responsivity to food cues varies with food fussiness in adolescents.Scientific reports · 2025Article
- Foundations of Pediatric Lifestyle Medicine.Children (Basel, Switzerland) · 2025Article
- The prediction model of academic achievement based on cardiorespiratory fitness and BMI status for ninth-grade students.BMC pediatrics · 2025Article
- Shared and distinct alterations in brain morphology in children with ADHD and obesity: Reduced cortical surface area in ADHD and thickness in overweight/obesity.Journal of psychiatric research · 2024Article
- The role of child BMI growth in neurodevelopment and school readiness-Current landscape and future directions.Paediatric and perinatal epidemiology · 2024Article
- GABA (gamma-aminobutyric acid) levels in dorsal anterior cingulate cortex are negatively associated with food motivation in a pediatric sample.Scientific reports · 2024Article
- Childhood Obesity, Hypothalamic Inflammation, and the Onset of Puberty: A Narrative Review.Nutrients · 2024Review
- Longitudinal Associations of Body Fatness and Physical Fitness with Cognitive Skills in Preschoolers.Children (Basel, Switzerland) · 2024Article
- Thymoquinone: A comprehensive review of its potential role as a monotherapy for metabolic syndrome.Iranian journal of basic medical sciences · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
Obesity and components of the metabolic syndrome (MetS) are associated with differences in brain structure and function and in general and food-related cognition in adults. Here, we review evidence for similar phenomena in children and adolescents, with a focus on the implications of extant research for possible underlying mechanisms and potential interventions for obesity and MetS in youth. Current evidence is limited by a relative reliance on small cross-sectional studies. However, we find that youth with obesity and MetS or MetS components show differences in brain structure, including alterations in grey matter volume and cortical thickness across brain regions subserving reward, cognitive control and other functions, as well as in white matter integrity and volume. Children with obesity and MetS components also show some evidence for hyperresponsivity of food reward regions and hyporesponsivity of cognitive control circuits during food-related tasks, altered brain responses to food tastes, and altered resting-state connectivity including between cognitive control and reward processing networks. Potential mechanisms for these findings include neuroinflammation, impaired vascular reactivity, and effects of diet and obesity on myelination and dopamine function. Future observational research using longitudinal measures, improved sampling strategies and study designs, and rigorous statistical methods, promises to further illuminate dynamic relationships and causal mechanisms. Intervention studies targeted at modifiable biological and behavioural factors associated with paediatric obesity and MetS can further inform mechanisms, as well as test whether brain and behaviour can be altered for beneficial outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.