SynthesisBMJ open2023
Minimal important change and difference for knee osteoarthritis outcome measurement tools after non-surgical interventions: a systematic review.
Synthesis in BMJ open, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03460236 (Precision Assessment of Platelet Rich Plasma for Joint Preservation), which is not on this map. Cited by 38 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Precision Assessment of Platelet Rich Plasma for Joint Preservation
Who cites it
38 citing papers in PubMed, 3 syntheses or guidelines pooled it, 53 citations in OpenAlex.
- Factors Contributing to Variability in Longitudinal Pain Scores in Osteoarthritis Randomised Clinical Trials: A Systematic Review and Meta-Analysis.European journal of pain (London, England) · 2026Pooled it
- Pulsed Electromagnetic Field Therapy in People with Knee Osteoarthritis: A Systematic Review and Meta-Analysis.Medicina (Kaunas, Lithuania) · 2026Pooled it
- Effectiveness and safety of probiotics in treating knee osteoarthritis: an updated systematic review and meta-analysis of randomized controlled trials.Frontiers in medicine · 2026Pooled it
- A comparative study of the efficacy of single and double centrifuged platelet-rich plasma and placebo (normal saline injection) on pain, ROM, and physical function of patients with knee osteoarthritis: a double-blinded controlled randomized trial with a six-month follow-up.Advances in rheumatology (London, England) · 2026Trial
- Laboratory-selected, probioticFrontiers in nutrition · 2026Trial
- Myofascial Trigger Point-Augmented Acupuncture vs Conventional Acupuncture for Early- to Mid-Stage Knee Osteoarthritis: A Randomized Clinical Trial.Journal of pain research · 2026Trial
- Blood flow restriction with different loads versus moderate intensity resistive exercises in patients with knee osteoarthritis: a single-blind randomized controlled trial.BMC sports science, medicine & rehabilitation · 2026Article
- Circulating sTLR4 and sTREM-1 in Knee Osteoarthritis: Associations with Study-Specific MRI-Defined Categories and Disease Burden.Journal of clinical medicine · 2026Article
- Ultrasound-Guided Posteromedial Fascial-Periarticular Injection for Mild-to-Moderate Knee Osteoarthritis: Twelve-Month WOMAC Outcomes in a Retrospective Pilot Case Series.Diagnostics (Basel, Switzerland) · 2026Article
- Development of Data-Driven Models for Just-in-Time Digital Self-Management Advice to Improve Physical Functioning in Hip and Knee Osteoarthritis: Protocol for the e-cOAch Cross-Over Study.JMIR research protocols · 2026Article
- Synovial Biomarker Modulation and Clinical Response to Umbilical Cord-Derived MSC Treatment in Knee Osteoarthritis: A Case Series Study.Cartilage · 2026Article
- From Real-World Practice to an Ideal Rehabilitation Pathway in Osteoarthritis: A Delphi Consensus on Patient Itineraries.Journal of clinical medicine · 2026Article
- Clinical characteristics and physical activity levels of patients with knee osteoarthritis with and without a previous knee injury: A cross-sectional study.Osteoarthritis and cartilage open · 2026Article
- Influence of major trauma and lower limb loss on radiographic progression and incidence of knee osteoarthritis and pain: a comparative and predictive analysis from the ADVANCE study.Arthritis research & therapy · 2026Article
- Predicting Long-Term Pain Resilience in Knee Osteoarthritis: An Osteoarthritis Initiative Nomogram.Bioengineering (Basel, Switzerland) · 2026Article
- The Link Between Depression, Analgesia Usage and Function in Osteoarthritis: A Propensity Score-Matched Analysis from the Osteoarthritis Initiative Cohort.Bioengineering (Basel, Switzerland) · 2026Article
- Comparative Effectiveness of Low-Dose Intra-Articular Ozone Therapy for Pain and Functional Outcomes in Patients with Knee Osteoarthritis: A Retrospective Cohort Study.Journal of pain research · 2026Article
- Pain sensitization as a potentially modifiable factor in people with knee osteoarthritis: insights from behavioral graded activity.Frontiers in pain research (Lausanne, Switzerland) · 2026Article
- Additional Benefits of Creatine Supplementation with Physical Therapy and Resistance Exercise in Knee Osteoarthritis: A Randomized Controlled Trial.Journal of clinical medicine · 2025Article
- Minimal important change of the knee injury and osteoarthritis outcome score in patients with mild to moderate knee osteoarthritis - using three different anchor-based methods.Osteoarthritis and cartilage open · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo systematically review and provide estimates of the minimal important change (MIC) and difference (MID) for outcome tools in people with knee osteoarthritis (OA) after non-surgical interventions. DATA SOURCES: MEDLINE, CINAHL, Web of Science, Scopus and Cochrane databases were searched up to 21 September 2021. ELIGIBILITY CRITERIA: We included studies that calculated MIC and MID using any calculation method including anchor, consensus and distribution methods, for any knee OA outcome tool after non-surgical interventions. DATA EXTRACTION AND SYNTHESIS: We extracted reported MIC, MID and minimum detectable change (MDC) estimates. We used quality assessment tools appropriate to the studies' methods to screen out low-quality studies. Values were combined to produce a median and range, for each method.
resultsForty-eight studies were eligible (anchor-k=12, consensus-k=1 and distribution-k=35). MIC values for 13 outcome tools including Knee injury and Osteoarthritis Outcome Score (KOOS)-pain, activities of daily living (ADL), quality of life (QOL) and Western Ontario and McMaster Universities Arthritis Index (WOMAC)-function were estimated using 5 high-quality anchor studies. MID values for 23 tools including KOOS-pain, ADL, QOL and WOMAC-function, stiffness and total were estimated using 6 high-quality anchor studies. One moderate quality consensus study reported MIC for pain, function and global assessment. MDC values from distribution method estimates for 126 tools including KOOS-QOL and WOMAC-total were estimated using 38 good-to-fair-quality studies.
conclusionMedian MIC, MID and MDC estimates were reported for outcome tools in people with knee OA after non-surgical interventions. The results of this review clarify the current understanding of MIC, MID and MDC in the knee OA population. However, some estimates suggest considerable heterogeneity and require careful interpretation. PROSPERO REGISTRATION NUMBER: CRD42020215952.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.