ArticleNeuroImage2023
Brain morphometry in older adults with and without dementia using extremely rapid structural scans.
Article in NeuroImage, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 26 citations in OpenAlex.
- Precision estimates of longitudinal brain aging capture unexpected individual differences in one year.Nature communications · 2026Article
- Clinical translation of fluid, imaging, and digital biomarkers for Alzheimer's disease.Alzheimer's research & therapy · 2026Review
- DunedinPACNI estimates the longitudinal Pace of Aging from a single brain image to track health and disease.Nature aging · 2025Article
- Ultra-fast MRI for dementia diagnosis and treatment eligibility: A prospective study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- An estimate of the longitudinal pace of aging from a single brain scan predicts dementia conversion, morbidity, and mortality.bioRxiv : the preprint server for biology · 2025Article
- Reliability of structural brain change in cognitively healthy adult samples.bioRxiv : the preprint server for biology · 2025Article
- Optimizing ultra-rapid compressed-sensing MPRAGE acquisitions for brain morphometry.Frontiers in neuroimaging · 2025Article
- Reliability of structural brain change in cognitively healthy adult samples.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Ultra-low-field brain MRI morphometry: Test-retest reliability and correspondence to high-field MRI.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Automated quality control of T1-weighted brain MRI scans for clinical research datasets: methods comparison and design of a quality prediction classifier.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Article
- Circadian Rhythms Tied to Changes in Brain Morphology in a Densely Sampled Male.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Design and validation of the ADNI MR protocol.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Review
- Precision brain morphometry using cluster scanning.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Preserving cognitive function in patients with Alzheimer's disease: The Alzheimer's disease neuroprotection research initiative (ADNRI).Neuroprotection (Chichester, England) · 2023Article
- Detecting short-interval longitudinal cortical atrophy in neurodegenerative dementias via cluster scanning: A proof of concept.Imaging neuroscience (Cambridge, Mass.)Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
T1-weighted structural MRI is widely used to measure brain morphometry (e.g., cortical thickness and subcortical volumes). Accelerated scans as fast as one minute or less are now available but it is unclear if they are adequate for quantitative morphometry. Here we compared the measurement properties of a widely adopted 1.0 mm resolution scan from the Alzheimer's Disease Neuroimaging Initiative (ADNI = 5'12'') with two variants of highly accelerated 1.0 mm scans (compressed-sensing, CSx6 = 1'12''; and wave-controlled aliasing in parallel imaging, WAVEx9 = 1'09'') in a test-retest study of 37 older adults aged 54 to 86 (including 19 individuals diagnosed with a neurodegenerative dementia). Rapid scans produced highly reliable morphometric measures that largely matched the quality of morphometrics derived from the ADNI scan. Regions of lower reliability and relative divergence between ADNI and rapid scan alternatives tended to occur in midline regions and regions with susceptibility-induced artifacts. Critically, the rapid scans yielded morphometric measures similar to the ADNI scan in regions of high atrophy. The results converge to suggest that, for many current uses, extremely rapid scans can replace longer scans. As a final test, we explored the possibility of a 0'49'' 1.2 mm CSx6 structural scan, which also showed promise. Rapid structural scans may benefit MRI studies by shortening the scan session and reducing cost, minimizing opportunity for movement, creating room for additional scan sequences, and allowing for the repetition of structural scans to increase precision of the estimates.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.