ArticleChemical senses2023
An inhibitory mechanism for suppressing high salt intake in Drosophila.
Article in Chemical senses, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 12 citations in OpenAlex.
- Molecular and neural mechanisms of sodium sensation.Genes & genomics · 2026Review
- A flexible synthetic diet platform for Drosophila nutrigenomics.Genes & nutrition · 2026Article
- Activity and State-Dependent Modulation of Salt Taste Behavior Via Pharyngeal Neurons inNeuroscience insights · 2026Article
- Dietary salt induces taste desensitization via receptor internalization in Drosophila in a sexually dimorphic manner.Molecules and cells · 2025Article
- Opponent coding mechanisms in Drosophila taste neurons.Chemical senses · 2025Review
- Molecular and cellular basis of sodium sensing iniScience · 2024Article
- Article
- Diverse mechanisms of taste coding inScience advances · 2023Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
High concentrations of dietary salt are harmful to health. Like most animals, Drosophila melanogaster are attracted to foods that have low concentrations of salt, but show strong taste avoidance of high salt foods. Salt in known on multiple classes of taste neurons, activating Gr64f sweet-sensing neurons that drive food acceptance and 2 others (Gr66a bitter and Ppk23 high salt) that drive food rejection. Here we find that NaCl elicits a bimodal dose-dependent response in Gr64f taste neurons, which show high activity with low salt and depressed activity with high salt. High salt also inhibits the sugar response of Gr64f neurons, and this action is independent of the neuron's taste response to salt. Consistent with the electrophysiological analysis, feeding suppression in the presence of salt correlates with inhibition of Gr64f neuron activity, and remains if high salt taste neurons are genetically silenced. Other salts such as Na2SO4, KCl, MgSO4, CaCl2, and FeCl3 act on sugar response and feeding behavior in the same way. A comparison of the effects of various salts suggests that inhibition is dictated by the cationic moiety rather than the anionic component of the salt. Notably, high salt-dependent inhibition is not observed in Gr66a neurons-response to a canonical bitter tastant, denatonium, is not altered by high salt. Overall, this study characterizes a mechanism in appetitive Gr64f neurons that can deter ingestion of potentially harmful salts.
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